Phospholipids

Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.

Also Known As:

Networked: 4030 relevant articles (75 outcomes, 337 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tsimikas, Sotirios: 28 articles (09/2015 - 09/2004)
2.	Witztum, Joseph L: 25 articles (09/2015 - 01/2002)
3.	Leitinger, Norbert: 19 articles (11/2011 - 01/2002)
4.	Bochkov, Valery N: 18 articles (11/2013 - 01/2002)
5.	Berliner, Judith A: 12 articles (06/2013 - 03/2002)
6.	Birukov, Konstantin G: 11 articles (03/2015 - 10/2004)
7.	Rapoport, Stanley I: 11 articles (12/2014 - 01/2003)
8.	Makarov, V K: 9 articles (01/2013 - 01/2003)
9.	Thorpe, Philip E: 9 articles (01/2011 - 11/2002)
10.	Binder, Bernd R: 9 articles (12/2010 - 01/2002)

Related Diseases

1.	Neoplasms (Cancer) 12/15/2004 - "Both LDL and albumin were effective in delivering FA to tumor cells and modifying the composition of cell phospholipids. " 02/15/2005 - "In the present study, we tested the hypothesis that a monoclonal antibody directed against anionic phospholipids might exert antitumor effects by causing vascular damage in tumors. " 11/01/2002 - "In the present study, we determined whether anionic phospholipids become exposed on tumor vasculature. " 10/01/2015 - "2D-imaging MS of the most differentially expressed phospholipids confirmed their differential abundance in cancer cells. " 08/01/2015 - "Phosphatidylserine (PS) and other anionic phospholipids, which become exposed on the surface of proliferating endothelial cells, tumor cells and certain leukocytes, have been used as targets for the development of clinical-stage biopharmaceuticals. "
2.	Bipolar Disorder (Mania) 03/01/2011 - "VPA's ability to inhibit Acsl4 activation of AA and of DHA to their respective acyl-CoAs, when related to the higher catalytic efficiency of AA than DHA conversion, may account for VPA's selective reduction of AA turnover in rat brain phospholipids, and contribute to VPA's efficacy against bipolar disorder." 12/01/2010 - "  Altered metabolism of membrane phospholipids has been implicated in bipolar disorder. " 05/30/2001 - "Published literature comparing 31P MR brain spectra of bipolar patients to healthy controls was evaluated, focusing on phosphomonoester (PME)/phosphodiester (PDE) resonance areas because these metabolites are related to membrane phospholipids and membrane defects in bipolar disorder have been suggested. " 10/01/2011 - "Consistent with reduced AA turnover, OLZ decreased brain cyclooxygenase activity and the brain concentration of the proinflammatory AA-derived metabolite, prostaglandin E₂, In view of up-regulated brain AA metabolic markers in bipolar disorder, the abilities of OLZ and the mood stabilizers to commonly decrease prostaglandin E₂, and AA turnover in rat brain phospholipids, albeit by different mechanisms, may be related to their efficacy against the disease." 04/01/2013 - "Mood stabilizers used for treating bipolar disorder (BD) selectively downregulate arachidonic acid (AA) turnover (deacylation-reacylation) in brain phospholipids, when given chronically to rats. "
3.	Body Weight (Weight, Body) 08/01/2013 - "The results showed that neither fish oil nor n-3 PUFAs enriched egg yolk phospholipids supplementation reversed disturbances caused by CMS, such as anhedonic-like state or reduction of body weight gain." 08/01/2013 - "Effects of supplementation with fish oil and n-3 PUFAs enriched egg yolk phospholipids on anhedonic-like response and body weight in the rat chronic mild stress model of depression." 04/01/2013 - "Multiple stepwise regression models revealed that baPWV was significantly influenced by systolic blood pressure, age, body weight, triglyceride and LA in serum phospholipids (R(2) = 0.378). " 10/01/2010 - "EPA in plasma phospholipids, energy intake, resting energy expenditure (REE), body weight, fat free mass (FFM), mid-upper arm circumference (MUAC), and inflammatory markers were assessed. " 01/01/2007 - "The level of tissue phospholipids increased significantly when DA was administered at a dose of 10 mg/kg body weight along with alcohol when compared with alcohol control group. "
4.	Anoxia (Hypoxia) 09/01/1993 - "Finally, these studies suggested that alterations in phospholipids during hypoxia occurred to a greater extent in compartments of endothelial cells other than the plasma membranes and that the well-recognized tolerance of endothelial cells to hypoxia may be due, in part, to preservation of the integrity of their plasma membranes during exposure to acute and chronic hypoxia." 01/01/1993 - "Studies of the structural changes of erythrocytic phospholipids and their free-radical oxidation in health and intrauterine hypoxia in 61 parturients and their fetuses have shown that, despite a variety of causes of intrauterine hypoxia, the structural changes of fetal red cells are virtually the same and present as enlarged crystals and more marked crystallization of the phospholipid layer of the membrane. " 01/01/2014 - "In the tumor microenvironment, apoptotic cells are abundant due to hypoxia, and PAF-like phospholipids are generated. " 09/01/2006 - "Fatty acid composition of phospholipids of the cell nuclei from the rat brain after hypoxia at different periods of ontogeny." 03/01/2004 - "Previous hypobaric hypoxic hypoxia reduced the level of total phospholipids as well as PS at simultaneous increase of LPL. "
5.	Inflammation 01/01/2012 - "Other beneficial effects included reduced markers of inflammation, improved lung gas exchange, liver function, antioxidant status and fatty acid composition of plasma phospholipids, and a trend towards less impairment of kidney function. " 02/01/2014 - "Mass spectrometry and inflammation--MS methods to study oxidation and enzyme-induced changes of phospholipids." 01/01/2015 - "PAF-AH catalyzes the removal of the acyl group at the sn-2 position of PAF and truncated phospholipids generated in settings of inflammation and oxidant stress. " 01/01/2015 - "These genes were primarily involved in (a) pro-angiogenic and regenerative pathways and (b) the generation of oxidized phospholipids with known pro-angiogenic and inflammation-modulating properties. " 01/21/2014 - "Free radical-induced oxidation of phospholipids contributes significantly to pathologies associated with inflammation and oxidative stress. "

Related Drugs and Biologics

1.	Cholesterol
2.	Triglycerides (Triacylglycerol)
3.	Nonesterified Fatty Acids (NEFA)
4.	Arachidonic Acid (Vitamin F)
5.	Lipids
6.	Lithium
7.	Lipoproteins (Lipoprotein)
8.	Liposomes (Liposome)
9.	Phospholipases A2 (Phospholipase A2)
10.	Adenosine Triphosphate (ATP)

Related Therapies and Procedures

1.	Oral Administration
2.	Injections
3.	Aftercare (After-Treatment)
4.	Splenectomy
5.	Chinese Traditional Medicine (Traditional Chinese Medicine)