Phospholipase D

An enzyme found mostly in plant tissue. It hydrolyzes glycerophosphatidates with the formation of a phosphatidic acid and a nitrogenous base such as choline. This enzyme also catalyzes transphosphatidylation reactions. EC 3.1.4.4.

Also Known As:

Networked: 344 relevant articles (4 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Min, Do Sik: 20 articles (01/2015 - 04/2002)
2.	Foster, David A: 15 articles (12/2010 - 03/2003)
3.	Gomez-Cambronero, Julian: 7 articles (09/2015 - 01/2010)
4.	Brown, H Alex: 7 articles (05/2015 - 10/2002)
5.	Kang, Dong Woo: 7 articles (08/2014 - 09/2009)
6.	Zheng, Yang: 7 articles (07/2008 - 03/2003)
7.	Lindsley, Craig W: 6 articles (05/2015 - 02/2009)
8.	Choi, Kang-Yell: 6 articles (01/2015 - 05/2010)
9.	Park, Mi Hee: 6 articles (01/2015 - 12/2007)
10.	Min, D S: 6 articles (04/2014 - 05/2000)

Related Diseases

1.	Lymphadenitis (Adenitis) 12/01/1999 - "Vaccination with genetically detoxified phospholipase D (DeltaPLD) has been shown to be effective, at least partially, against Corynebacterium pseudotuberculosis, the causal agent of caseous lymphadenitis in sheep. " 02/26/1999 - "Efficacy of an ovine caseous lymphadenitis vaccine formulated using a genetically inactive form of the Corynebacterium pseudotuberculosis phospholipase D." 12/01/1995 - "Caseous lymphadenitis vaccine development: site-specific inactivation of the Corynebacterium pseudotuberculosis phospholipase D gene." 04/01/1982 - "Twenty-five strains of Corynebacterium pseudotuberculosis isolated from lesions of caseous lymphadenitis in goats were examined for their biochemical characteristics, antimicrobial susceptibility, and phospholipase D activity. " 06/01/1990 - "Corynebacterium pseudotuberculosis produces a sphingomyelin-specific phospholipase D exotoxin that is a major determinant in the pathogenesis of caseous lymphadenitis. "
2.	Ischemia 10/01/1997 - "In view of the previous observations that ischemia-reperfusion potentiates phospholipase D signaling and that such signaling is beneficial for the heart, we investigated whether a similar phospholipase D signaling is responsible for the beneficial effects associated with repeated ischemia and reperfusion. " 10/01/1997 - "The results of this study indicate that repeated brief episodes of ischemia and reperfusion exert beneficial effects on the intact rat heart by triggering the activation of a phospholipase D signaling mechanism." 05/01/2000 - "Upregulation of phospholipase D in astrocytes in response to transient forebrain ischemia." 04/01/2005 - "Differential changes in phospholipase D and phosphatidate phosphohydrolase activities in ischemia-reperfusion of rat heart." 11/04/1996 - "The results identifies for the first time tyrosine kinase-phospholipase D as potential signaling pathway for ischemic preconditioning, and implicates the involvement of multiple protein kinases in myocardial adaptation to ischemia."
3.	Infection 07/01/2013 - "Infection of phospholipase D β1 (PLDβ1)-deficient plants by Pseudomonas syringae tomato pv DC3000 (Pst DC30000) resulted in less bacterial growth than in wild-type plants, and the effect was more profound in virulent Pst DC3000 than avirulent Pst DC3000 (carrying the avirulence gene avrRpt2) infection. " 03/01/2007 - "A conserved mechanism appears to be involved in controlling infection by both of these pathogens, as a role for phospholipase D in inducing fusion between lysosomes and the vacuoles has been demonstrated. " 01/01/2001 - "Genetic and biochemical analyses of a eukaryotic-like phospholipase D of Pseudomonas aeruginosa suggest horizontal acquisition and a role for persistence in a chronic pulmonary infection model." 12/01/1998 - "Phospholipase D-neutralization in serodiagnosis of Arcanobacterium haemolyticum and Corynebacterium pseudotuberculosis infections." 05/01/2011 - "Importantly, phospholipase D (PLD)α1 or PLDδ mutants, which are impaired in PA synthesis do not show growth promotion in response to fungal infection. "
4.	Neoplasms (Cancer) 10/28/2005 - "Recent studies have revealed that elevated phospholipase D activity generates survival signals in breast and perhaps other human cancers. " 09/01/2014 - "Phospholipase D is a target to modulate cancer-cell invasiveness. " 08/15/2014 - "Thematic minireview series on phospholipase D and cancer." 04/01/2014 - "Phospholipase D-mediated autophagic regulation is a potential target for cancer therapy." 01/15/2011 - "Phospholipase D meets Wnt signaling: a new target for cancer therapy."
5.	Astrocytoma (Pilocytic Astrocytoma) 02/28/2006 - "Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells." 05/01/1998 - "Functional coupling of the NK1 tachykinin receptor to phospholipase D in chinese hamster ovary cells and astrocytoma cells." 02/28/2006 - "Elevated expression of protein casein kinase II (CKII) stimulated basal phospholipase D (PLD) activity as well as PMA-induced PLD activation in human U87 astroglioma cells. " 09/01/2004 - "We show that epigallocatechin-3 gallate (EGCG), a major component of green tea, stimulates phospholipase D (PLD) activity in U87 human astroglioma cells. " 10/01/1995 - "Mastoparan-induced phosphatidylcholine hydrolysis by phospholipase D activation in human astrocytoma cells."

Related Drugs and Biologics

1.	Vaccines
2.	Bacterial Vaccines
3.	1-dodecylpyridoxal (PLD)
4.	Phosphotransferases (Kinase)
5.	Tyrosine (L-Tyrosine)
6.	Phosphatidic Acids (Phosphatidic Acid)
7.	Phosphatidylcholines (Phosphatidylcholine)
8.	Type C Phospholipases
9.	Isoenzymes
10.	Protein-Tyrosine Kinases (Tyrosine Kinase)

Related Therapies and Procedures

1.	Surgical Instruments (Clip)
2.	Mastectomy (Mammectomy)
3.	Cardiopulmonary Bypass (Heart-Lung Bypass)
4.	Oral Administration