Phosphate Acetyltransferase

An enzyme that catalyzes the synthesis of acetylphosphate from acetyl-CoA and inorganic phosphate. Acetylphosphate serves as a high-energy phosphate compound. EC 2.3.1.8.

Also Known As:

Phosphotransacylase; Phosphotransbutyrylase; Acetyltransferase, Phosphate; Phosphoacylase; Phosphotransacetylase; Acetyl-CoA:orthophosphate acetyltransferase

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Acyltransferases: 374
      - Acetyltransferases: 1040
        Phosphate Acetyltransferase: 5

Experts

1.	Burne, Robert A: 2 articles (01/2017 - 08/2015)
2.	Kim, Jeong Nam: 2 articles (01/2017 - 08/2015)
3.	Ahn, Sang-Joon: 1 article (08/2015)
4.	Mazzio, Elizabeth A: 1 article (06/2010)
5.	Smith, Bruce: 1 article (06/2010)
6.	Soliman, Karam F A: 1 article (06/2010)
7.	Baars, Louise: 1 article (09/2007)
8.	Klussmeier, Anja: 1 article (09/2007)
9.	Nord, Olof: 1 article (09/2007)
10.	Nygren, Per-Ake: 1 article (09/2007)

Related Diseases

1.	Dental Caries (Decay, Dental) 01/01/2017 - "In the dental caries pathogen Streptococcus mutans, phosphotransacetylase (Pta) and acetate kinase (Ack) convert pyruvate into acetate with the concomitant generation of ATP. " 08/01/2015 - "In the dental caries pathogen Streptococcus mutans, phosphotransacetylase (Pta) catalyzes the conversion of acetyl coenzyme A (acetyl-CoA) to acetyl phosphate (AcP), which can be converted to acetate by acetate kinase (Ack), with the concomitant generation of ATP. "
2.	Neoplasms (Cancer) 06/01/2010 - "In conclusion, these results provide preliminary evidence to suggest the existence of an active pyruvate-alanine transaminase or phosphotransacetylase/acetyl-CoA synthetase pathway to be involved with anaerobic energy metabolism of cancer cells."
3.	Fatty Liver 11/25/1980 - "Highly purified rat liver fatty acid synthetase is completely inhibited when assayed in the presence of a coenzyme A-depleting system such as that catalyzed by phosphotransacetylase, acetyl-CoA synthetase, or ATP citrate lyase. "
4.	AIDS-Related Complex (ARC) 09/01/2007 - "Induction of the acetate-phosphotransacetylase pathway for ATP production and a down-regulated tricarboxylic acid cycle indicated the activation of the Arc two-component system, which mediates adaptive responses to changing respiratory states. "

Related Drugs and Biologics

1.	Adenosine Triphosphate (ATP)
2.	Acetates (Acetic Acid Esters)
3.	Pyruvic Acid (Pyruvate)
4.	Acetate-CoA Ligase (Acetyl CoA Synthetase)
5.	Acetate Kinase
6.	Ligases (Synthetase)
7.	Coenzyme A (CoA)
8.	ATP Citrate (pro-S)-Lyase (Citrate Synthase, ATP)
9.	Alanine Transaminase (SGPT)
10.	Acids