Phlorhizin

03/14/2021 - "Moreover, phloridzin led to the enhanced phosphorylation of AMPK and Akt relevant to increased insulin sensitivity. "
01/01/1998 - "Discontinuation of phloridzin treatment in diabetic rats resulted in the recurrence of insulin resistance. "
04/01/1988 - "We conclude that phlorizin is associated with insulin resistance perhaps by a common pathway shared by chronic hyperglycaemia. "
04/01/1988 - "Antecedent chronic hyperglycaemia blocks phlorizin-induced insulin resistance in the dog."
05/01/1987 - "Discontinuation of phlorizin in phlorizin-treated diabetic rats resulted in the reemergence of insulin resistance. "

11/07/2018 - "Results of the study indicate the possibility of unfavorable effects of phloridzin on the musculoskeletal system in conditions of hyperglycemia."
08/01/2017 - "Hyperglycemia results in functional and morphological changes in these cells, but these effects are attenuated by phlorizin, a nonselective SGLT inhibitor. "
12/06/2013 - "Intraperitoneal (i.p.) administration of phlorizin (a specific and competitive inhibitor of SGLT, 200mg/kg immediately after reperfusion) suppressed the development of post-ischemic hyperglycemia on day 1 after BCAO. "
01/01/2012 - "The inhibition of SGLT2 by phlorizin prevents the hyperglycemia and oxidative stress in kidney of diabetic rats, suggesting a prooxidative mechanism related to SGLT2 activity."
01/01/2005 - "The rapid recovery of the pancreas by phlorizin-induced normoglycemia implies a causal relationship between hyperglycemia and islet dysfunction. "

04/01/2015 - "These findings suggest that phlorizin is effective in protecting skin against UVB-induced skin damage by decreasing ROS overproduction, Cox-2 expression and the subsequent excessive inflammation reactions. "
01/01/2022 - "The functional abilities of phlorizin on hippocampal-dependent spatial learning and memory, anti-oxidation, anti-inflammation were also observed. "
01/01/2018 - "Inflammation in the bladder was present in the diabetic animals at this time point, but not detectable in animals receiving phlorizin. "
01/01/2019 - "The loss of function of SGLT1 by phlorizin are related to the augmented disease severity, increased atelectasis, bronchial inflammation and a significant reduction of survival rate of CLP rats. "
02/16/2016 - "We investigated the beneficial effects of phlorizin on obesity and its complications, including diabetes and inflammation in obese animal. "

03/14/2021 - "These results strongly suggest that phloridzin could be used as a potential therapeutic candidate for the treatment of type 2 diabetes."
03/20/2019 - "Comparative oral and intravenous pharmacokinetics of phlorizin in rats having type 2 diabetes and in normal rats based on phase II metabolism."
08/01/2017 - "With phlorizin as lead compound, specific inhibitors of SGLT2 were developed in the last decade and some of them have been approved for treatment mainly of type 2 diabetes. "
10/12/2016 - "Sixteen obese mice with type 2 diabetes (db/db) and eight age-matched control mice (db/+) were divided into three groups: diabetic group treated with phlorizin (DMT group), vehicle-treated diabetic group (DM group), and normal control group (CC group). "
12/15/2021 - "Ameliorative potential of phloridzin in type 2 diabetes-induced memory deficits in rats."

03/30/2019 - "Although, tri-acetylated phloridzin has moderate to minimal adverse-effects on LO-2, its anti-proliferative activity against human HepG2 cancer cells is superior to that of phloridzin, which attributes to its high capacity of inducing cell apoptosis, retarding cell cycle, lowering mitochondrial membrane potential and scavenging intracellular ROS."
11/01/1993 - "The efficacy of phloridzin and phloretin on tumor cell growth."
07/01/2021 - "Notably, phlorizin might inhibit the proteins in the JAK/STAT signaling pathway, which would affect cancer cells. "
03/30/2019 - "Lipase-catalyzed synthesis mechanism of tri-acetylated phloridzin and its antiproliferative activity against HepG2 cancer cells."
01/01/2014 - "We have investigated the anticarcinogenic effect of phloridzin and its novel derivatives using human cancer cell lines. "