Phlorhizin

12/06/2013 - "Intraperitoneal (i.p.) administration of phlorizin (a specific and competitive inhibitor of SGLT, 200mg/kg immediately after reperfusion) suppressed the development of post-ischemic hyperglycemia on day 1 after BCAO. "
01/01/2012 - "The inhibition of SGLT2 by phlorizin prevents the hyperglycemia and oxidative stress in kidney of diabetic rats, suggesting a prooxidative mechanism related to SGLT2 activity."
01/01/2005 - "The rapid recovery of the pancreas by phlorizin-induced normoglycemia implies a causal relationship between hyperglycemia and islet dysfunction. "
06/01/2003 - "ZDF rats were treated with phlorizin or vehicle for 13 weeks starting with 6-week-old rats and before the onset of hyperglycemia. "
12/01/2002 - "To determine the importance of reducing hyperglycemia per se, diabetic rats were treated either with a single ED(50) dose of BMOV (0.1 mmol/kg, ip) or with phlorizin (900 mg/kg.d, 5 d). "

08/01/1984 - "Phlorizin caused mild hypoglycemia with hypoinsulinemia. "
01/01/1980 - "Fetal metabolic response to phloridzin-induced hypoglycemia in pregnant rats."
06/01/2010 - "Initially the counterregulatory response to identical hypoglycemia was compared during intravenous insulin and phloridzin infusion in awake chronically catheterized nondiabetic rats. "
02/01/1989 - "2) Restoration of euglycemia with phlorizin does not restore normal IRG and epinephrine responses to hypoglycemia but restores the delayed increase of Ra. "
05/01/1988 - "Twenty mature, lactating Hereford-cross cows were used to determine the effect of phlorizin-induced hypoglycemia on gonadotropin secretion following prostaglandin-induced luteolysis. "

01/01/2014 - "Based on the high selectivity on cancer cells, decosahexaenoic acid (DHA) ester of phloridzin was selected for gene expression analysis using RT2PCR human cancer drug target array. "
01/01/2014 - "We have investigated the anticarcinogenic effect of phloridzin and its novel derivatives using human cancer cell lines. "
11/01/1993 - "The efficacy of phloridzin and phloretin on tumor cell growth."
10/01/2004 - "These effects might offer a promising novel method in designing functional foods for cancer prevention by combining genistin- and phloridzin-containing foods."
03/01/1955 - "[Mitosis in the ascites tumor in the rat after administration of trimethylcolchicinic acid methyl ester alone or in combination with phlorhizin]."

01/01/2014 - "Phlorizin but not 2-MPG improved the ischemic conduction slowing at 15 and 20 min of ischemia. "
01/01/2015 - "To test the functional significance of the substantial expression of SGLTs in the heart, we studied the effects of a non-selective SGLT inhibitor, phlorizin, on the baseline cardiac function and its response to ischemia-reperfusion using the murine Langendorff model. "
01/01/2014 - "Phlorizin may be more useful for ischemia-induced VT than 2-MPG."
01/01/2014 - "These results indicate that phlorizin prevents VT through the improvement of impulse conduction slowing during ischemia. "
01/01/2014 - "LVEDP was increased during 30 min of ischemia in the control and in the presence of 2-MPG but not in the presence of phlorizin. "

03/15/1977 - "Effects of cerebral lateral, ventricular infusions of phloridzin on feeding and body weight in Gallus domesticus (L.)."
10/01/2012 - "Phlorizin (20 mg/kg body weight) was given in normal saline solution intragastrically for 10 weeks. "
05/01/2012 - "Phlorizin significantly decreased body weight gain and the levels of glucose, TC and TG in blood. "
06/01/2003 - "Phlorizin prevented the decrease in plasma insulin levels and caused a higher increase in body weight of the ZDF rats. "
02/01/2001 - "Treatment of control and GK rats with phlorizin for 30 days did not affect body weight, islet glucose utilization, or islet glucose oxidation. "