Phloretin

01/01/2018 - "The leading compound 6d, the IC50 of which with the GLUT1 inhibitor 4,6-oethylidene-α-D-glucose (EDG) and phloretin (31.80 and 38.71 μM) are 36- and 44-folds higher, respectively, than the 48 h IC50 (0.89 μM), is superior to the reported 5-8, exhibiting enhanced cancer targeting. "
01/13/2019 - "The efficacy of phloretin in suppressing xenograft tumor growth in athymic nude mice implanted with a variety of human cancer cells, and the ability of the compound to interfere with cancer cells signaling, have made it a promising candidate for anti-cancer drug development. "
01/01/2020 - "Studies have reported the anticancer effects of Phloretin against different human cancer cells. "
01/01/2020 - "Studies have shown that Phloretin exerts anticancer effects on several types of cancer cells. "
09/01/2023 - "Mechanistically, phloretin exhibits anti-tumor potential via inactivating STAT3 signaling and enhancing Nrf2 activity. "

09/14/2007 - "Taken together, these results suggest that phloretin may be beneficial for reducing insulin resistance through its potency to regulate adipocyte differentiation and function."
02/15/2023 - "These findings suggested that 3-OH phloretin has the potential to be a natural bioactive compound that can be used in the prevention or treatment of obesity and insulin resistance."
12/01/2014 - "These findings suggested that phloretin might be able to increase insulin sensitivity and alleviate the metabolic diseases. "
06/01/2023 - "Phloretin and phlorizin mitigates inflammatory stress and alleviate adipose and hepatic insulin resistance by abrogating PPARγ S273-Cdk5 interaction in type 2 diabetic mice."
01/01/2017 - "The effects of phloretin treatment on body weight and composition, fat content in the liver, glucose and lipid metabolism, and insulin resistance were monitored and compared to the control animals. "

11/16/2022 - "Improved remyelination was attributed to a direct impact of phloretin on OPC maturation and occurred independently from alterations in microglia function and inflammation. "
09/01/2023 - "In this study we have explored the anti-inflammatory potential of phloretin, in in vitro gut inflammation model, developed by co-culture of Caco2 (intestinal epithelial) cells and RAW264.7 macrophages (immune cells). "
12/01/2021 - "Further mechanism studies showed that phloretin significantly inhibited inflammation and oxidative stress levels in the colonic tissue. "
02/01/2018 - "This study highlights the protective effect of phloretin on CS-related airway mucus hypersecretion and inflammation, where EGFR, ERK and P38 might be involved. "
09/01/2023 - "An anti-inflammatory effect of phloretin in reducing LPS induced inflammation and maintenance of transepithelial electric resistance (TEER) in Caco2 cells was examined. "

01/01/2020 - "In this study, we investigated whether phloretin ameliorates non-alcoholic fatty liver disease (NAFLD) in high-fat diet (HFD)-induced obese mice, and evaluated the regulation of lipid metabolism in hepatocytes. "
11/01/2023 - "Phloretin (Ph) is a natural phenolic compound, that exhibits a wide array of pharmacological actions including its efficacy towards NAFLD. "
01/01/2022 - "Further, phloretin was administered orally to western diet induced NAFLD in C57BL/6J mice at different doses. "
01/01/2022 - "Therefore, in the present study, we investigated the potential of phloretin to maintain redox equilibrium and prevent disease progression via modulation of autophagy in NAFLD. "
01/01/2022 - "Phloretin mitigates oxidative injury, inflammation, and fibrogenic responses via restoration of autophagic flux in in vitro and preclinical models of NAFLD."

01/01/2017 - "Our results demonstrate that phloretin is a promising anti-infective therapeutic for infections caused by L. "
08/01/2015 - "Our study suggests that phloretin might have a potential application in the development of treatment for MRSA infections."
11/04/2023 - "Moreover, these nanoparticles are pH-sensitive and degrade efficiently in the acidic infection microenvironment, gradually releasing Phloretin. "
12/01/2021 - "Phloretin is protective in a murine salmonella enterica serovar typhimurium infection model."
01/01/2021 - "Moreover, chemical disruption with the AQP9 inhibitor phloretin markedly inhibited hepatocyte infection. "