Phleomycins

Water-soluble, copper-containing low molecular weight polypeptides obtained from the culture medium of Streptomyces verticillus. They are specific inhibitors of DNA synthesis in bacteria and have been found to act as antitumor agents. They have also been used against rust fungi of plants.

Also Known As:

Networked: 24 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Haas, Hubertus: 2 articles (11/2018 - 01/2013)
2.	McKoy, J: 2 articles (11/2003 - 11/2001)
3.	Moore, C W: 2 articles (11/2003 - 11/2001)
4.	Pramanik, A: 2 articles (11/2003 - 11/2001)
5.	Chung, Seoyoung: 1 article (01/2021)
6.	Dronamraju, Raghuvar: 1 article (01/2021)
7.	Forester, Kaitlyn E: 1 article (01/2021)
8.	Robinson, Sophie B: 1 article (01/2021)
9.	Strahl, Brian D: 1 article (01/2021)
10.	Yoblinski, Andrew R: 1 article (01/2021)

Related Diseases

1.	Starvation 11/14/2018 - "These studies revealed that: (i) Nfs1 (Afu3g14240) and Nbp35 (Afu2g15960), which are involved in ISC and CIA, respectively, are essential for growth; (ii) a decrease in ISC (Nfs1 depletion) but not CIA (Nbp35 depletion) results in a transcriptional iron starvation response, (iii) a decrease in, ISC as well as CIA, increases the chelatable iron pool, accompanied by increased iron toxicity and increased susceptibility to oxidative stress and phleomycin. " 01/10/2013 - "The obtained iron-starvation dependent phleomycin resistance indicates the potential use of this promoter for selection marker recycling. " 01/10/2013 - "chrysogenum as shown by mir1(P)-driven and iron starvation-induced expression of genes encoding green fluorescence protein and phleomycin resistance. "
2.	Hypersensitivity (Allergy) 07/07/2010 - "Whilst interaction of TPR7-mutated FANCG with FANCF does appear to be reduced in NM3, FANCD2 is monoubiquitylated suggesting that sub-optimal interactions of FANCG in the core complex and the D1-D2-G-X3 complex are responsible for the observed MMC- and phleomycin-hypersensitivity, rather than a defect in FANCD2 monoubiquitylation. " 04/26/2009 - "When exposed to phleomycin or MMC, the mitochondrial mutant cells again showed hypersensitivity and decreased mitotic indices compared to normal cells. " 11/01/2003 - "Mutational alteration of the BLM5 gene of the model eukaryote, Saccharomyces cerevisiae, confers extreme hypersensitivities to lethal effects of ionizing radiation, anticancer bleomycins and structurally-related phleomycins. " 11/01/2001 - "Mutational alteration of the BLM3 gene in Saccharomyces cerevisiae confers hypersensitivities to lethal effects of ionizing radiation, anticancer bleomycins and structurally-related phleomycins. " 07/07/2010 - "Interestingly, a mutation of TPR7 (R563E), that complements the MMC and phleomycin hypersensitivity of human FA-G EUFA316 cells, fails to complement NM3, despite the mutated FANCG protein co-precipitating with FANCA, BRCA2 and XRCC3. "
3.	Neoplasms (Cancer) 03/01/1965 - "EFFECT OF PHLEOMYCIN ON DNA POLYMERASE OF TUMOR ORIGIN." 01/31/1963 - "Mechanism of action of phleomycin, a tumor-inhibitory antibiotic." 04/01/1984 - "Significant and often substantial enhancement of the antitumor properties of several individual phleomycins , by co- administration via intraperitoneal injection of a number of purine analogues, is demonstrated in rats and mice having three diverse tumors. " 04/01/1983 - "In our laboratory, we have studied the mechanism of action of tumor-inhibitory antibiotics, including bleomycin, phleomycin, adriamycin, aclarubicin, neothramycin, macromomycin, auromomycin, chartreusin, pluramycin, neopluramycin, xanthomycin A, angustmycins A and C, blasticidin S and phenomycin. "
4.	Chromosome Aberrations (Chromosome Abnormalities) 03/01/1969 - "Phleomycin-induced mitotic inhibition and chromosomal abnormalities in cultured human leucocytes." 04/26/2009 - "Here, ionizing radiation, phleomycin and mitomycin C (MMC) were used to induce structural chromosomal aberrations in Leber's and Leigh's cells to investigate how these mitochondrial mutations affect the cell's DNA repair processes. " 11/01/1982 - "The in vitro effects (strand breakage) of phleomycin and bleomycin are compared with induction of chromosomal aberrations in human lymphocytes and oocytes of Drosophila melanogaster."
5.	Chromosome Breakage 01/01/1995 - "Nevertheless, lysates from phleomycin-treated cells were considerably more cytotoxic than lysates from bleomycin-treated cells or freshly prepared bleomycin, consistent with the higher effectiveness of phleomycin than bleomycin in producing chromosomal breaks, genetic changes, and cell killing." 01/01/1995 - "Genetic changes and bioassays in bleomycin- and phleomycin-treated cells, and their relationship to chromosomal breaks." 12/01/1988 - "In vivo (cellular) repair of chromatin damage was comparable (approximately 90% in 1 h) after cells were exposed to low drug concentrations which produced similar numbers of chromatin breaks, and thus also does not account for the higher chromosomal breakage caused by phleomycin than bleomycin at low doses. "

Related Drugs and Biologics

1.	Iron
2.	Bleomycin (Blenoxane)
3.	Mitomycin (Mitomycin-C)
4.	Anti-Bacterial Agents (Antibiotics)
5.	Proteins (Proteins, Gene)
6.	Phleomycins
7.	DNA (Deoxyribonucleic Acid)
8.	Chromatin
9.	Fanconi Anemia Complementation Group G Protein
10.	Aclarubicin

Related Therapies and Procedures

1.	Intraperitoneal Injections