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Phenylthiazolylthiourea
A dopamine-beta-hydroxylase inhibitor.
Also Known As:
U-14,624; U 14,624; U14,624; Thiourea, N-phenyl-N'-2-thiazolyl-
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amides: 2428
Urea: 15015
Thiourea: 362
Phenylthiourea: 102
Phenylthiazolylthiourea: 2
Sulfur Compounds: 278
Thiourea: 362
Phenylthiourea: 102
Phenylthiazolylthiourea: 2
Related Diseases
1.
Tachycardia (Tachyarrhythmias)
05/01/1976 - "
2. Bupicamide and fusaric acid caused marked tachycardia whereas FLA-63 and U-14,624 caused modest bradycardia; all drugs decreased blood pressure.
"
2.
Lordosis
04/27/1979 - "
Thus, inhibition of lordosis after treatment with U-14,624 appeared to be attributable primarily to a reduction in NE neurotransmission, rather than to increase in DA or 5-HT activity.
"
04/27/1979 - "
Because clonidine induced lordosis in females treated with EB, P, and U-14,624, it seemed unlikely that the facilitatory effects of clonidine on lordosis were mediated by activation of presynaptic alpha-adrenergic receptors (i.e.
"
04/27/1979 - "
After treatment with U-14,624 (100 mg/kg), norepinephrine (NE) content of medial basal hypothalamus, preoptic area and cortex was reduced (by 55%) and dopamine (DA) content of medial basal hypothalamus was increased (by 155%) during the period when females treated with EB and P normally display lordosis.
"
04/27/1979 - "
Treatment with the dopamine beta-hydroxylase (DBH) inhibitor U-14,624 (50, 100, or 150 mg/kg) blocked the induction of lordosis behavior be estradiol benzoate (EB) and progesterone (P) in ovariectomized guinea pigs.
"
04/27/1979 - "
Treatment with the NE receptor stimulator clonidine (1.0 mg/kg) restored lordosis behavior in females treated with EB, P, and U-14,624 (100 mg/kg), but the putative DA and serotonin (5-HT) receptor blockers pimozide (1.0 mg/kg) and methysergide (20.0 mg/kg) were ineffective in this respect.
"
3.
Bradycardia
05/01/1976 - "
2. Bupicamide and fusaric acid caused marked tachycardia whereas FLA-63 and U-14,624 caused modest bradycardia; all drugs decreased blood pressure.
"
Related Drugs and Biologics
1.
Serotonin (5 Hydroxytryptamine)
2.
alpha Adrenergic Receptors
3.
Progesterone
4.
Pimozide (Orap)
5.
Norepinephrine (Noradrenaline)
6.
Methysergide (Sansert)
7.
Fusaric Acid
8.
Dopamine beta-Hydroxylase
9.
Dopamine (Intropin)
10.
Clonidine (ST 155)
Related Therapies and Procedures
1.
Aftercare (After-Treatment)