Phenylglyoxal

A reagent that is highly selective for the modification of arginyl residues. It is used to selectively inhibit various enzymes and acts as an energy transfer inhibitor in photophosphorylation.

Also Known As:

Networked: 11 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Austin, Caroline A: 1 article (01/2012)
2.	Burgos-Morón, Estefanía: 1 article (01/2012)
3.	Calderón-Montaño, José M: 1 article (01/2012)
4.	López-Lázaro, Miguel: 1 article (01/2012)
5.	Mateos, Santiago: 1 article (01/2012)
6.	Orta, Manuel L: 1 article (01/2012)
7.	Pastor, Nuria: 1 article (01/2012)
8.	Perez-Guerrero, Concepción: 1 article (01/2012)
9.	Jacobson, Elaine L: 1 article (02/2006)
10.	Jacobson, Myron K: 1 article (02/2006)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2012 - "This report shows that phenylglyoxal is a new DNA-damaging agent with anticancer activity, and suggests that tumor cells with defects in NER, HR and NHEJ may be hypersensitive to the cytotoxic activity of phenylglyoxal." 01/01/2012 - "Guanidine-reactive agent phenylglyoxal induces DNA damage and cancer cell death." 01/01/1976 - "Seven para-substituted [phenylglyoxal bis(4-methyl-3-thiosemicarbazone)]copper (II) chelates (12-18) have been designed, synthesized, and tested for their ability to inhibit the respiration of rat liver slices as a normal cell model and Ehrlich ascites cells as a tumor cell model. " 02/10/1980 - "Phenylglyoxal, an arginine-specific reagent, strongly inhibits DNA polymerases isolated from eukaryotic, prokaryotic, and RNA tumor viral sources as well as Escherichia coli RNA polymerase. "
2.	Fatty Liver 02/01/2000 - "Pigeon liver fatty acid synthetase was inactivated by arginine modifying reagent, phenylglyoxal and 2,3-butanedione. " 07/17/1984 - "Treatment of chicken liver fatty acid synthetase with the arginine-specific reagent phenylglyoxal resulted in the pseudo-first-order loss of synthetase, beta-ketoacyl reductase and enoyl reductase activities. "
3.	Uremia 10/01/2022 - "To investigate carbamylation as a potential mechanistic link between uremia and platelet dysfunction in ESKD, we used liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) to quantify total homocitrulline, and biotin-conjugated phenylglyoxal labeling and Western blot to detect carbamylated integrin α IIb β 3 (a receptor required for platelet aggregation). "
4.	Melanoma (Melanoma, Malignant) 02/01/2006 - "Indeed, in various melanoma cell lines, carbonyl scavenger-induced apoptosis was antagonized by pretreatment with the membrane-permeable RCS phenylglyoxal (PG). "
5.	Lung Neoplasms (Lung Cancer) 01/01/2012 - "Phenylglyoxal-induced cell death was partially prevented by catalase pretreatment and was higher in lung cancer cells (A549) than in normal lung fibroblasts (MRC5). "

Related Drugs and Biologics

1.	Arginine (L-Arginine)
2.	Indicators and Reagents (Reagents)
3.	Acids
4.	Ligases (Synthetase)
5.	Guanidine (Guanidine Nitrate)
6.	Porins
7.	Integrins
8.	Trinitrobenzenesulfonic Acid
9.	Thiosemicarbazones
10.	DNA-Directed RNA Polymerases (RNA Polymerase)