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Phenylethylmalonamide
A metabolite of primidone.
Also Known As:
2-Ethyl-2-Phenylmalonamide; 2 Ethyl 2 Phenylmalonamide; Ethylphenylmalonamide; Phenylethylmalondiamide; Propanediamide, 2-ethyl-2-phenyl-
Networked:
8
relevant articles (
3
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Carboxylic Acids: 973
Acyclic Acids
Dicarboxylic Acids: 108
Malonates: 1
Phenylethylmalonamide: 8
fenalamide
Related Diseases
1.
Seizures (Absence Seizure)
03/01/1983 - "
Neurotoxicity and protection against maximal electroshock (MES) and pentylenetrazol (Metrazol) seizures were determined in mice for various combinations of primidone (PRM), phenobarbital (PB), and phenylethylmalonamide (PEMA).
"
03/01/1983 - "
Neurotoxicity and protection against maximal electroshock and Metrazol seizures from primidone (PRM), phenobarbital (PB), and phenylethylmalonamide (PEMA) were determined in mice for each drug separately and expressed in terms of brain concentrations.
"
2.
Renal Insufficiency (Renal Failure)
05/01/1990 - "
Clearance of phenylethylmalonamide during haemodialysis of a patient with renal failure.
"
05/01/1990 - "
Information is presented for the serum concentrations during haemodialysis of primidone, phenobarbitone, and phenylethylmalonamide (PEMA) in a patient with renal failure receiving chronic primidone therapy.
"
3.
Essential Tremor (Essential Tremors)
10/01/1981 - "
Phenylethylmalonamide in essential tremor.
"
10/01/1981 - "
A randomised double-blind placebo-controlled trial of phenylethylmalonamide, the major metabolite of primidone was performed in eight patients with essential tremor.
"
4.
Epilepsy (Aura)
10/01/1980 - "
Monitoring 2-ethyl-2-phenylmalonamide in serum by gas-liquid chromatography: application to retrospective study in epilepsy patients dosed with primidone.
"
05/15/1983 - "
Fifteen dogs with idiopathic epilepsy were included in a 9-month clinical trial to determine the therapeutic serum concentrations of primidone and its active metabolites, phenobarbital and phenylethylmalonamide.
"
10/01/1980 - "
We describe a procedure for determining 2-ethyl-2-phenylmalonamide (I) in serum of epilepsy patients dosed with primidone (II) for seizure control, by extracting the sample with chloroform under basic conditions, with use of an internal standard, 2-ethyl-2-(p-tolyl)malonamide, and without derivative formation.
"
5.
Tremor (Tremors)
01/17/1981 - "
Investigations in two patients suggested that the effect was mediated predominantly by derived phenylethylmalonamide, though primidone had some effect, since tremor recurred slightly on withdrawing the drug despite a constant or rising blood phenylethylmalonamide concentration.
"
Related Drugs and Biologics
1.
Primidone (Sertan)
2.
Phenobarbital (Luminal)
3.
Pentylenetetrazole (Metrazol)
4.
Chloroform (Trichloromethane)
Related Therapies and Procedures
1.
Therapeutics