Phenylenediamines

Aniline compounds that contain two amino groups. They are used as a precursor in the synthesis of HETEROCYCLIC COMPOUNDS and POLYMERS. p-Phenylenediamine is used in the manufacture of HAIR DYES and is an ALLERGEN.

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Polyamines: 3918
    - Diamines: 518
      - Phenylenediamines: 6
        4-phenylenediamine: 433
        ezogabine: 227
        ferrostatin-1: 144
        N,N'-diphenyl-4-phenylenediamine: 45
        RGFP966: 42
        tribendimidine: 40
        tacedinaline: 38
        3-methyl-N,N-diethyl-p-phenylenediamine: 33
        N-isopropyl-N-phenyl-4-phenylenediamine: 24
        1,2-diaminobenzene: 19
        black rubber: 19
        4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine: 16
        dinaline: 14
        2,4-diaminotoluene: 11
        2,5-diaminotoluene: 9
        salphen: 7
        4-methoxy-3-phenylenediamine: 6
        Tetramethylphenylenediamine: 6
        4-aminodiphenylamine: 5
        2,6-diaminotoluene: 4
        4-((4-(((4-amino-2,3,5,6-tetramethylanilino)acetyl)(methyl)amino)-1-piperidinyl)methyl)benzamide: 4
        4-chloro-1,2-diaminobenzene: 4
        Bandrowski's base: 4
        HC Blue No. 2: 4
        N-methylamino-2-nitro-4-N',N'-bis(2-hydroxyethyl)aminobenzene: 4
        1,2-diamino-4-nitrobenzene: 3
        2,6-dichloro-1,4-phenylenediamine: 3
        3-phenylenediamine: 3
        amidantel: 3
        bis-5,5'-(2,4,2',4'-tetraminotolyl)methane: 3
        dimethyl-4-phenylenediamine: 3
        N,N'-diacetyl-p-phenylenediamine: 3
        T 691: 3
        2-chloro-4-phenylenediamine: 2
        4-chloro-3-phenylenediamine: 2
        dinitramine: 2
        ITX-5061: 2
        N,N-diethyl 4-phenylenediamine: 2
        N,N-dimethyl-p-phenylenediamine: 2
        N-(1,3-dimethylbutyl)-N'-phenyl-1,4-phenylenediamine: 2
        poly(o-phenylenediamine): 2
        1,4-diamino-2-methoxybenzene: 1
        2-(2',4'-diaminophenoxy)ethanol: 1
        2-amino-4-hydroxyethylaminoanisole: 1
        2-methoxymethyl-p-phenylenediamine: 1
        2-nitro-4-phenylenediamine: 1
        3,4-toluenediamine: 1
        3-nitro-o-phenylenediamine: 1
        4-trifluoromethyl-1,2-phenylenediamine: 1
        Ethacure 300: 1
        HC Red No. 3: 1
        N,N'-bis(7-chloroquinolin-4-yl)benzene-1,3-diamine: 1
        N,N,N'-triphenyl-4-phenylenediamine: 1
        1,2-diamino-4,5-dimethoxybenzene
        1,2-diamino-4,5-ethylenedioxybenzene
        1,2-diamino-4,5-methylenedioxybenzene
        2,3-diaminotoluene
        2,4-diacetylaminotoluene
        2,4-diaminobenzenesulfonic acid
        2,4-diaminoethoxybenzene
        2,4-diaminopropoxybenzene
        2,5-diamino-N,N'-di-(4-aminophenyl)-2,5-cyclohexadiene-1,4-diimine
        2,5-diaminobenzenesulfonic acid
        2,5-dichloro-1,4-phenylenediamine
        2,5-dimethyl-1,4-benzoquinonediamine
        2,6-diamino-3,5-diethyltoluene
        2-((2-acrylamido-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)(methyl)amino)-N,N-dimethylethan-1-amine oxide
        2-(4-acetamidylphenylamino)-4-(2-benzoylphenylamino)-5-nitropyrimidine
        2-aminodiphenylamine
        2-phenylenebis(N'-methyloxamidate)
        3,4-diaminobenzophenone
        3,4-diaminophenyliminoribitol
        3,5-diaminotrifluoromethylbenzene
        3,5-dibromo-1,2-phenylenediamine
        3-hydroxy-(4-amino)anilino-6,N-((4-amino)phenyl)benzoquinonemonoimine
        3-phenylenediaminoisophthalic acid
        4,5-dimethyl-1,2-phenylenediamine
        4-(2,3-dimethyl-6-quinoxalinyl)-1,2-benzenediamine
        4-chloro-5-fluoro-1,2-phenylenediamine
        5,7-diamino-4,6-dinitrobenzofuroxan
        5-((4-(((4-methoxyphenyl)-oxoacetyl) methylamino)phenyl)methylamino)-5-oxopentanoic acid
        5-((4-(((4-methoxyphenyl)oxoacetyl)amino)phenyl)amino)-5-oxopentanoic acid
        BAY-d 9216
        benzene-1,4-bis(aminomethylidene(bisphosphonic)) acid
        bis(4-((5-chloro-2-pyridyl)azo)-1,3-diaminobenzene)cobalt(II)
        bis(m-N,N-dimethylaminomethylphenyl)phosphinomethanethiol
        chlorido(N,N'-disalicylidene-1,2-phenylenediamine)iron(III)
        CP 28888-27
        curing agent Z
        diafen NN
        diaminodurene
        ethyl N-(2-amino-4-((4-fluorobenzyl)(prop-2-ynyl)amino)phenyl)carbamate
        HC yellow No. 5
        hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine)
        N(2)-(4-(dimethylamino)benzoyl)-4-hydroxy-N(1)-(4-methoxybenzoyl)-1,2-benzenediamine
        N,N'-bis(1-naphthaldimine)-o-phenylenediamine
        N,N'-bis(2-hydroxybenzylidene)benzene-1,4-diamine
        N,N'-bis(carboxymethyl)-N,N'-dinitroso-p-phenylenediamine
        N,N'-dicyclohexyl-4-phenylenediamine
        N,N,N',N'-tetrakis(2-pyridylmethyl)benzene-1,4-diamine
  - Aniline Compounds: 46
    - Phenylenediamines: 6

Experts

1.	Chen, Yen-Ling: 1 article (01/2019)
2.	Ko, Hung-Yu: 1 article (01/2019)
3.	Lin, Yi-Hui: 1 article (01/2019)
4.	Shih, Chi-Jen: 1 article (01/2019)
5.	Agerberth, B: 1 article (11/2016)
6.	Bergman, P: 1 article (11/2016)
7.	Gudmundsson, G H: 1 article (11/2016)
8.	Miraglia, E: 1 article (11/2016)
9.	Nylén, F: 1 article (11/2016)
10.	Ottosson, H: 1 article (11/2016)

Related Diseases

1.	Carcinogenesis 06/01/1989 - "Toxicology and carcinogenesis studies of 2 structurally-related p-phenylenediamines, HC Blue No. 1, and HC Blue No. 2 were conducted by administering each chemical in feed for 103 weeks to both sexes of Fischer 344/N rats and B6C3F1 (C57BL/6N x C3H/HEN) mice. "
2.	Necrosis 01/01/1990 - "A number of N-methylated p-phenylenediamines are known to cause necrosis of skeletal and cardiac muscle in rats. " 08/01/1989 - "Muscle necrosis by N-methylated p-phenylenediamines in rats: structure-activity relationships and correlation with free-radical production in vitro."
3.	Infections 01/01/2023 - "Our research aimed to use synthetized aroylated phenylenediamines (APDs) to induce the expression of cathelicidin antimicrobial peptide gene (CAMP) to minimize the necessity of antibiotic use during infection. " 11/09/2016 - "A new concept for treatment of infections is induction of our own antimicrobial peptides and the presented novel class of inducer, aroylated phenylenediamines (APDs), gives up to 20 to 30-fold induction of the human antimicrobial peptide LL-37, in vitro. "
4.	Dermatitis 01/01/2019 - "Phenylenediamines (PDs), which are reported to cause allergic dermatitis and possess genotoxicity and carcinogenicity, are the ingredients used in permanent hair dyes. "
5.	Myotoxicity 01/01/1990 - "Myotoxicity appears to be a general property of certain substituted p-phenylenediamines and the structure-activity relationships identified may permit an estimate to be made of the potential toxicity of other compounds of this type." 01/01/1990 - "Structure-activity relationships in the myotoxicity of ring-methylated p-phenylenediamines in rats and correlation with autoxidation rates in vitro."

Related Drugs and Biologics

1.	HC Blue No. 2
2.	N- methylamino- 2- nitro- 4- N',N'- bis(2- hydroxyethyl)aminobenzene
3.	Cathelicidins
4.	Hair Dyes
5.	Free Radicals
6.	Anti-Bacterial Agents (Antibiotics)
7.	Antimicrobial Peptides