Phenoxybenzamine

An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.

Also Known As:

Dibenylene; Dibenyline; Dibenziran; Dibenzylin; Dibenzyline; Dibenzyran; Phenoxybenzamine Hydrochloride; Hydrochloride, Phenoxybenzamine; Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-

Networked: 644 relevant articles (34 outcomes, 39 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Ethylamines: 5
    - Phenoxybenzamine: 644

Experts

1.	Inchiosa, Mario A: 3 articles (01/2018 - 03/2008)
2.	Huang, Yuguang: 2 articles (12/2021 - 10/2017)
3.	Tong, Anli: 2 articles (01/2021 - 01/2020)
4.	McKenzie, Travis J: 2 articles (10/2017 - 06/2017)
5.	Young, William F: 2 articles (10/2017 - 06/2017)
6.	Kulik, Alexander: 2 articles (05/2015 - 02/2007)
7.	Atwell, Thomas D: 2 articles (01/2011 - 03/2006)
8.	Callstrom, Matthew R: 2 articles (01/2011 - 03/2006)
9.	Charboneau, J William: 2 articles (01/2011 - 03/2006)
10.	Seefelder, Christian: 2 articles (02/2009 - 07/2005)

Related Diseases

1.	Pheochromocytoma 01/01/2023 - "This study investigated whether other agents have supplanted the use of phenoxybenzamine as the first-line agent for alpha blockade in pheochromocytoma. " 12/01/2023 - "Thirty-seven of 45 (82%) dogs with pheochromocytomas not pretreated survived to discharge, and 50 of 59 (85%) dogs with pheochromocytomas pretreated with phenoxybenzamine survived to discharge (p = 0.730). " 01/01/2023 - "There has been a significant shift away from phenoxybenzamine for preoperative blockade before resection of pheochromocytoma. " 05/01/2022 - "He was recently diagnosed with pheochromocytoma and was commenced on Phenoxybenzamine 10 mg two months back. " 03/01/2022 - "Pretreatment of pheochromocytoma with phenoxybenzamine is associated with reduced surgical mortality risk. "
2.	Neoplasms (Cancer) 01/01/2018 - "Studies by others have reported inhibitory effects of phenoxybenzamine on growth, invasion and migration of human tumor cell cultures and, in one study, inhibition of tumor expansion in animal experiments. " 01/01/2022 - "Preoperative preparation with phenoxybenzamine was initiated, and a 4-cm tumor was surgically resected. " 06/01/2018 - "The resection of bilateral adrenal tumors was conducted after the preoperative medical treatment of phenoxybenzamine for two weeks. " 07/13/2011 - "After adequate alpha blockage with phenoxybenzamine, laparoscopic tumor resection was performed without complications. " 08/01/2006 - "Active surgical treatment and phenoxybenzamine resulted in low tumor-related mortality in groups 2 and 3; five patients died 8-30 years after diagnosis, four of PC/PG (three from group 2 and one from group 3) and one of other causes. "
3.	Urinary Retention 10/01/1988 - "Phenoxybenzamine and urinary retention." 01/01/1988 - "In 21 of these 26 patients, urinary retention disappeared within 48 hours following phenoxybenzamine administration." 09/01/1985 - "Prophylactic phenoxybenzamine treatment is recommended as an alternative to routine bladder drainage in preventing urinary retention following vaginal repair operations for genital descensus." 03/01/1978 - "In one group of 21 patients who received phenoxybenzamine prophylactically only one patient had urinary retention develop; nine of 22 patients in the control group who did not receive prophylactic phenoxybenzamine postoperatively had urinary retention develop. " 01/01/1987 - "The efficacy of phenoxybenzamine in preventing postoperative urinary retention after total hip arthroplasty was investigated in a double-blind placebo-controlled study on 60 consecutive male patients with obstructive urinary symptoms. "
4.	Pain (Aches) 01/01/2012 - "Finally, phenoxybenzamine improved his pain significantly. " 05/01/1981 - "Rest pain, local tenderness, trophic skin changes, and vasospastic phenomena improved in the majority of patients soon after beginning treatment with phenoxybenzamine. " 09/16/2010 - "Evaluation of phenoxybenzamine in the CFA model of pain following gene expression studies and connectivity mapping." 01/01/2013 - "Also, a recent study identified phenoxybenzamine as a potential intervention for pain mediation from its effects on gene expression in human cell lines; on this basis, it was tested and found to be capable of reducing pain behavior in a classical animal model of chronic pain. " 02/01/1988 - "In one patient the alpha-adrenoceptor blocker, phenoxybenzamine alleviated cold-induced pain. "
5.	Shock 01/01/1987 - "Liver blood flow during haemorrhagic shock in the dog treated with phenoxybenzamine." 01/01/1982 - "They express the hypothesis of an inhibition hyper-reflex of sympathetic origin, reversible under phenoxybenzamine treatment, consider the urodynamic evaluation and the therapeutic treatment and compare this type of neurogenic vesical dysfunction to that of the spinal shock." 12/01/1980 - "Treatment of severe shock with phenoxybenzamine." 05/01/1977 - "When compared to the untreated shock animals, phenoxybenzamine caused an 83% increase in RBF and a 53% decrease in RVR. " 05/01/1977 - "Urinary excretion of Na+, K+, and total solute were studied in 10 anesthetized dogs before and after administration of phenoxybenzamine (PBZ) in shock. "

Related Drugs and Biologics

1.	Adrenergic Agents (Adrenergic Drugs)
2.	Propranolol (Inderal)
3.	alpha-Methyltyrosine (Metirosine)
4.	Adrenergic beta-Antagonists (beta-Adrenergic Blocking Agents)
5.	Phenoxybenzamine
6.	Prazosin (Minipress)
7.	alpha Adrenergic Receptors
8.	Catecholamines
9.	Haloperidol (Haldol)
10.	Epinephrine (Adrenaline)

Related Therapies and Procedures

1.	Adrenalectomy
2.	Therapeutics
3.	Cardiopulmonary Bypass (Heart-Lung Bypass)
4.	Hip Replacement Arthroplasty (Total Hip Replacement)
5.	Aftercare (After-Treatment)