Phenothiazines

08/01/1976 - "Possible reasons for the improved prognosis in schizophrenia are considered to be short initial hospitalization, almost universal use of phenothiazines, use of developing community services (social and psychiatric), and generally good econimic conditions."
01/01/1967 - "Prediction of improvement in schizophrenia under four phenothiazines."
02/04/1961 - "A comparative evaluation of two phenothiazines in the management of chronic schizophrenia."
11/01/1972 - "Work study in the assessment of the effects of phenothiazines in schizophrenia."
01/01/1972 - "Performance tests in a study of phenothiazines in schizophrenia: caveats and conclusions."

09/01/1992 - "In order to study the correlation between the anti-tumor activity of benzo[a]phenothiazines and the electron densities, the Huckel orbital method and modified-neglect-of-diatomic overlap (MNDO) orbital method were used. "
01/01/1991 - "The present research studies suggest that many phenothiazines do not show significant antitumor and antineoplastic activity and so they cannot be used as potential drugs to treat cancer. "
08/01/1983 - "This study suggests the possible novel use of phenothiazines to improve drug sensitivity of tumors resistant to ADR treatment."
01/01/2011 - "Our data highlight the potential benefit of using phenothiazines as chemosensitizers in tumors that acquire molecular alterations rendering them insensitive to caspase-mediated apoptosis."
09/01/2009 - "Further investigation including other phenothiazines, biological systems, and cancer models is required."

10/01/2009 - "The relative efficacy of phenothiazines for the treatment of acute migraine: a meta-analysis."
10/01/2009 - "We searched MEDLINE, EMBASE, CINAHL, Cochrane database, and international clinical trial registers for randomized controlled trials comparing parenteral phenothiazines with placebo or another active parenteral agent for treatment of acute migraine in adults. "
08/01/2010 - "Phenothiazines in migraine treatment."
04/20/2010 - "Review: phenothiazines relieve acute migraine headaches in the ED and are better than other active agents for some outcomes."
10/01/2009 - "Phenothiazines are more effective than placebo for the treatment of migraine headache and have higher rates of clinical success than other agents against which they have been compared."

03/13/1989 - "These findings suggest that phenothiazines may be useful for preserving neurologic function when administered shortly after the onset of CNS ischemia."
01/01/1990 - "This study suggests that phenothiazines could be beneficial in reducing cellular injury by reducing the levels of lipid peroxides during pathological conditions like ischemia."
03/01/1991 - "The present study suggests that phenothiazines can improve cardiac performance and preservation of myocytes by preventing calcium stimulatory effect on degradative enzymes and may represent a potential clinical tool in modifying myocardial injury induced by ischemia and reperfusion."
03/13/1989 - "We found substantial alterations in reactions catalyzed by calcium/phospholipid-dependent and calcium/calmodulin-dependent protein kinases during CNS ischemia which suggested that phenothiazines, drugs capable of inhibiting these reactions, might reduce neurologic damage. "

01/01/1981 - "The influence of phenothiazines on pain experience is uncertain."
07/01/1992 - "Due to the fact that the double-blind clinical studies of pain are mainly subjective, and difficult to quantify, the usefulness of phenothiazines for the sole purpose of potentiation of analgesia is questionable, especially in view of the many side effects of this group of drugs."
01/01/1959 - "II. Treatment of pain syndromes (nerve root pains, headaches) by phenothiazines]."
08/01/1996 - "Elders, especially if demented, may not have the usual external "pain behaviors." 3. Do not routinely use antiemetics, especially phenothiazines. "
10/01/1987 - "Analgesics, anti-inflammatory drugs, phenothiazines, tricyclic antidepressants, and the tricyclic muscle relaxant cyclobenzaprine have been used; low doses of amitriptyline or cyclobenzaprine provide increased control of pain and mood.(ABSTRACT TRUNCATED AT 250 WORDS)"