Phenindione

An indandione that has been used as an anticoagulant. Phenindione has actions similar to WARFARIN, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)

Also Known As:

2-Phenyl-1,3-indandione; Dindevan; Fenilin; Phenylindanedione; Phenyline; Pindione; 2 Phenyl 1,3 indandione; 1H-Indene-1,3(2H)-dione, 2-phenyl-

Networked: 61 relevant articles (0 outcomes, 1 trials/studies)

Drug Context: Research Results

Experts

1.	Hart, Tanya: 1 article (02/2015)
2.	Natarajan, Balan: 1 article (02/2015)
3.	Parry, Robin Geoffrey: 1 article (02/2015)
4.	Smith, Sophy: 1 article (02/2015)
5.	Jokhi, Percy: 1 article (08/2007)
6.	Ooi, Adrian: 1 article (08/2007)
7.	Sharma, Rajan: 1 article (08/2007)
8.	Simpson, Iain A: 1 article (08/2007)
9.	Tsang, Geoff M: 1 article (08/2007)
10.	Berry, Neil G: 1 article (06/2005)

Related Diseases

1.	Hemorrhoids 01/01/1961 - "[Treatment of hemorrhoids with suppositories with a pindione base]." 03/19/1960 - "[Therapeutic trial of phenylindanedione ("pindione") in suppository form in hemorrhoids]."
2.	Agranulocytosis (Granulocytopenia) 08/27/1966 - "[Agranulocytosis occurring during treatment with phenylindanedione]." 01/01/1960 - "Agranulocytosis associated with phenindione: a case report with review of the literature." 09/01/1959 - "Fatal agranulocytosis due to phenylindanedione: report of a case." 06/30/1956 - "Agranulocytosis and scarlatiniform eruption due to phenindione." 09/01/1953 - "AGRANULOCYTOSIS IN TWO PATIENTS RECEIVING PHENYLINDANEDIONE."
3.	Hepatitis 01/01/1964 - "[CHOLESTATIC HEPATITIS DUE TO PHENYL-INDANE-DIONE (PINDIONE)]." 08/13/1960 - "Hepatitis due to phenindione sensitivity." 03/01/1960 - "Dermattis, hepatitis and nephritis due to phenindione (phenylindandione)." 12/18/1965 - "Sensitivity reaction to phenindione with urticaria, hepatitis, and pancytopenia." 12/01/1957 - "Severe sensitivity reaction (hepatitis, dermatitis and pyrexia) attributable to phenylindanedione."
4.	Acute Kidney Injury (Acute Renal Failure) 03/01/1971 - "[New case of acute kidney failure due to phenindione]." 04/01/1970 - "Phenindione sensitivity and acute renal failure." 07/03/1965 - "ACUTE RENAL FAILURE IN PHENINDIONE SENSITIVITY." 01/15/1972 - "[Chronic interstitial nephritis due to phenylindanedione following an acute renal insufficiency]." 10/01/2001 - "However, severe immuno-allergic complications, especially acute hepatitis, acute renal failure and acute bone marrow failure, have been described with phenindione therapy. "
5.	Thrombosis (Thrombus) 08/01/1962 - "The effect of phenindione on rats fed diets which produce thrombosis or experimental atherosclerosis." 08/01/2007 - "We present a case of acute prosthetic mitral valve thrombosis in a patient whose anticoagulation was inadequate after phenindione was changed to low molecular weight heparin. " 11/01/1969 - "The effects and clinical significance of heparin and phenindione on a standard experimental femoral venous thrombus." 11/01/1969 - "A comparison of the anticoagulant effects of heparin and phenindione on a standard experimental arterial thrombus." 01/01/1989 - "In a patient with a lupus-like systemic disease, having received phenindione for 11 years, LA was discovered in association with recurrent deep venous thrombosis, a right atrial thrombus, coronary occlusion, arterial hypertension, thrombopenia, and anticardiolipin antibodies without anti-DNA antibodies. "

Related Drugs and Biologics

1.	Phenindione
2.	Anticoagulants
3.	Heparin (Liquaemin)
4.	Vitamin K
5.	Vitamin K 1 (Phylloquinone)
6.	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)
7.	Dicumarol (Dicoumarol)
8.	Vitamin K 3 (Menadione)
9.	Nadroparin (Nadroparin Calcium)
10.	Anticardiolipin Antibodies

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)