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Phencyclidine Abuse

Subscribe to New Research on Phencyclidine Abuse

The misuse of phencyclidine with associated psychological symptoms and impairment in social or occupational functioning.

Also Known As:

Abuse, Angel Dust; Abuse, PCP; Abuse, Phencyclidine; Phencyclidine Abuses; Phencyclidine Related Disorders; Phencyclidine-Related Disorder; Angel Dust Abuse; PCP Abuse; Phencyclidine-Related Disorders

Networked: 27 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Schizophrenia (Dementia Praecox)
2.	Substance-Related Disorders (Drug Abuse)
3.	Substance Withdrawal Syndrome (Withdrawal Symptoms)
4.	Infection

Experts

1.	Windhorst, A D: 1 article (11/2014)
2.	Willems, R: 1 article (11/2014)
3.	Metaxas, A: 1 article (11/2014)
4.	Klein, P J: 1 article (11/2014)
5.	Leysen, J E: 1 article (11/2014)
6.	Donck, L Ver: 1 article (11/2014)
7.	Berckel, B N M van: 1 article (11/2014)
8.	Kooijman, E J M: 1 article (11/2014)
9.	Renjaän, V A: 1 article (11/2014)
10.	Egerland, Ute: 1 article (05/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Phencyclidine Abuse:

1.	Clozapine (Clozaril)FDA LinkGeneric 07/01/1998 - "Furthermore, our results suggest that the prototype (clozapine) and a candidate (M100907) atypical APDs might be effective in ameliorating schizophrenic symptoms including cognitive and neuropsychological deficits, which are induced in humans who abuse PCP. "
2.	MDL 100907IBA 07/01/1998 - "Furthermore, our results suggest that the prototype (clozapine) and a candidate (M100907) atypical APDs might be effective in ameliorating schizophrenic symptoms including cognitive and neuropsychological deficits, which are induced in humans who abuse PCP. "
3.	Phencyclidine (Angel Dust)IBA 05/01/1986 - "As a result of frequent phencyclidine (PCP) abuse, pyrolysis studies were conducted to further investigate its fate during smoking. " 05/01/2012 - "Clinical data indicate that phencyclidine (PCP) abuse may induce symptoms resembling negative symptoms in humans. " 05/18/1990 - "Phencyclidine (PCP) abuse is reaching alarming proportions. " 01/01/1989 - "Despite the persistence of phencyclidine (PCP) abuse as a public health problem in many urban areas of the United States, there are no published data on outpatient treatment outcome. " 12/01/1988 - "Phencyclidine (PCP) abuse has diminished since PCP's intrusion into American culture in the late 1970s. "
4.	LigandsIBA 10/31/1996 - "Further studies using receptor selective ligands and sensitive probes that could associate with the pharmacological actions of PCP may elucidate the mechanisms of PCP abuse."
5.	Cocaine (Cocaine HCl)IBA 01/01/2006 - "Transcriptional changes common to human cocaine, cannabis and phencyclidine abuse." 01/01/2006 - "Microarray analysis was employed to assay brain gene expression in postmortem anterior prefrontal cortex (aPFC) from 42 human cocaine, cannabis and/or phencyclidine abuse cases and 30 control cases, which were characterized by toxicology and drug abuse history. " 01/01/1987 - "Space-based abstinence: alleviation of withdrawal symptoms in combinative cocaine-phencyclidine abuse." 03/01/1986 - "Treatment of depression in chronic cocaine and phencyclidine abuse with desipramine."
6.	Crack CocaineIBA 07/01/1989 - "The degree of PCP abuse in a metropolitan area may be related to the availability and cost of other, more highly coveted drugs, such as crack cocaine."
7.	Antipsychotic Agents (Antipsychotics)IBA 07/01/1998 - "These effects are similar to those produced by many atypical antipsychotics and suggests that this class of drugs should be investigated further for their potential utility as antipsychotics and as treatments for PCP abuse."
8.	Street Drugs (Illicit Drugs)IBA 08/01/1978 - "The clinical manifestations of phencyclidine abuse may include bizarre neuropsychiatric symptoms, which may mimic the untoward reactions of a variety of illicit drugs. "
9.	Phosphotransferases (Kinase)IBA 03/01/2001 - "These results demonstrate that chronic infusion of PCP in rats produces a differential and brain region-specific activation of MAP kinases, suggesting a role for the ERK signaling pathway in PCP abuse and perhaps in schizophrenia."
10.	Methadone (Dolophine)FDA LinkGeneric 03/01/1980 - "Urine and serum samples from emergency room patients with neuropsychiatric symptoms and methadone clinic patients and autopsy material showed a significant incidence of PCP abuse, particularly among adolescents and young adults."

Therapies and Procedures

1.	General Anesthesia 07/06/1984 - "This finding has implications for PCP abuse and also for the use of its derivative in general anesthesia, where it may contribute to postoperative infection."