Phencyclidine (Angel Dust)

A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.

Also Known As:

Networked: 1007 relevant articles (35 outcomes, 104 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Nabeshima, Toshitaka: 22 articles (06/2022 - 05/2004)
2.	Meltzer, Herbert Y: 16 articles (01/2022 - 05/2003)
3.	Klamer, Daniel: 14 articles (03/2011 - 02/2004)
4.	Neill, Joanna C: 13 articles (01/2022 - 03/2008)
5.	Javitt, Daniel C: 13 articles (12/2012 - 01/2003)
6.	Mouri, Akihiro: 12 articles (06/2022 - 12/2005)
7.	Pålsson, Erik: 11 articles (03/2011 - 07/2006)
8.	Harte, Michael K: 10 articles (01/2022 - 12/2008)
9.	Rajagopal, Lakshmi: 10 articles (01/2022 - 12/2010)
10.	Noda, Yukihiro: 10 articles (01/2019 - 12/2005)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 07/01/2011 - "While group II agonists are effective in several animal models of schizophrenia, they are reported to lack efficacy in moderating the effects of phencyclidine (PCP) on prepulse inhibition of acoustic startle in animal models of sensory processing deficits found in this disorder. " 10/02/2023 - "We used the well-established rodent subchronic phencyclidine (PCP) model to test the efficacy of NU-1223 on episodic memory, using novel object recognition (NOR) task, positive (locomotor activity), and negative symptoms (social interaction) of schizophrenia (SCH). " 01/01/2013 - "Phencyclidine-induced hypermotility in mice and inhibition of conditioned avoidance response in rats were assessed to estimate efficacy against the positive and social withdrawal test in rats was used to predict efficacy against the negative symptoms of schizophrenia. " 09/01/2012 - "Several compounds demonstrated efficacy in animal models of schizophrenia, including conditioned avoidance response and a pro-psychotic phencyclidine hyperactivity model." 01/01/2021 - "In the current study, LET prevented sensitization to phencyclidine (PCP) treatment, impairment of cognition, and affective behavioral abnormalities in an animal model of schizophrenia induced by prenatal PCP treatment. "
2.	Psychotic Disorders (Schizoaffective Disorder) 05/01/1984 - "The efficacy of ECT in phencyclidine-induced psychosis." 02/05/2004 - "This is based primarily on studies showing that phencyclidine, an NMDAR antagonist, can induce a schizophreniform psychosis. " 02/01/1982 - "Candidate mechanisms underlying phencyclidine-induced psychosis: an electrophysiological behavioral, and biochemical study." 01/01/2022 - "Behaviourally Dlg2+/- rats show a potentiated locomotor response to phencyclidine, as is typical of psychotic disorder models, in the absence of deficits in the other behavioural phenotypes assessed here. " 06/01/2015 - "Lest we feel too confident in the completeness of our understanding, and to inspire redoubled curiosity, I briefly describe a preliminary observation from our work with the psychosis-inducing drug phencyclidine (PCP). "
3.	Memory Disorders (Memory Loss) 03/01/2012 - "Preclinical studies indicate improved spatial working memory and reversal of phencyclidine-induced learning and memory deficits. " 01/01/2021 - "Therefore, we compared subchronic phencyclidine performance in standard novel object recognition task to that using the continuous novel object recognition task, which offers minimal distraction, allowing disease-relevant memory deficits to be assessed directly. " 01/01/2007 - "The drug reversed (MED: 0.3 mg/kg) selective attention impaired by neonatal phencyclidine (PCP) treatment and restored MK-801- or PCP-induced memory deficits in the Morris or linear maze (MED: 1-3 mg/kg). " 02/01/1984 - "If the inhibition observed in the brain homogenate occurs in vivo it may account for the high incidence of memory loss reported with phencyclidine use." 11/01/2018 - "Phencyclidine dose optimisation for induction of spatial learning and memory deficits related to schizophrenia in C57BL/6 mice."
4.	Cognitive Dysfunction 09/01/2000 - "These data suggest that long-term phencyclidine exposure induces frontostriatal-like cognitive impairments and may represent a potential (drug induced) model for the study of prefrontal cortical cognitive and dopaminergic dysfunction." 01/01/2021 - "Phencyclidine-induced cognitive impairments in repeated touchscreen visual reversal learning tests in rats." 12/06/2017 - "Because these oscillations arise from local inhibitory synaptic activity, these findings point to excitation-inhibition discoordination as the root of PCP-induced cognitive impairment.SIGNIFICANCE STATEMENT Hippocampal neural discharge is temporally coordinated on timescales of theta and gamma oscillations in the LFP and the discharge of a subset of pyramidal neurons called "place cells" is spatially organized such that discharge is restricted to locations called a cell's "place field." Because this temporal coordination and spatial discharge organization is thought to represent spatial knowledge, we used the psychotomimetic phencyclidine (PCP) to disrupt cognitive behavior and assess the importance of neural coordination and place fields for spatial cognition. " 10/31/2014 - "Accordingly, NMDAR antagonists such as phencyclidine (PCP) are used widely in experimental animals to model cognitive impairment associated with this disorder. " 09/01/2014 - "Subchronic treatment with phencyclidine (PCP) induced cognitive impairment in both novel object recognition (NOR) and attentional set-shifting (ID-ED) tests in rats. "
5.	Seizures (Absence Seizure) 01/01/1982 - "Phencyclidine inhibition of the rate of development of amygdaloid kindled seizures." 06/28/1988 - "Various compounds that have been identified in the literature as binding to the [3H]phencyclidine receptor site and as producing behavioral effects similar to phencyclidine (phencyclidine-like) protected mice from maximal electric shock-induced tonic-extensor seizures. " 06/01/2012 - "We present 2 cases of false-positive phencyclidine qualitative urine drug screen results in patients with seizures from tramadol misuse or abuse. " 10/01/2001 - "The specific mechanisms by which low concentrations of cyclosporine induce seizures and low concentrations of phencyclidine provoke behavioral excitation remain to be elucidated. " 09/16/1994 - "Chronic neonatal phencyclidine treatment produces age-related changes in pentylenetetrazol-induced seizures."

Related Drugs and Biologics

1.	N-Methylaspartate (NMDA)
2.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
3.	Antipsychotic Agents (Antipsychotics)
4.	Ketamine
5.	Dizocilpine Maleate (Dizocilpine)
6.	piperidine
7.	blonanserin
8.	Amphetamine (Amfetamine)
9.	Dopamine (Intropin)
10.	Hallucinogens (Psychedelics)

Related Therapies and Procedures

1.	Self Administration (Administration, Self)
2.	Oral Administration
3.	Therapeutics
4.	Injections
5.	Analgesia