Phencyclidine (Angel Dust)

A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.

Also Known As:

Networked: 730 relevant articles (23 outcomes, 77 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Nabeshima, Toshitaka: 13 articles (02/2015 - 05/2004)
2.	Javitt, Daniel C: 13 articles (12/2012 - 01/2003)
3.	Klamer, Daniel: 11 articles (12/2010 - 02/2004)
4.	Roth, Robert H: 8 articles (04/2015 - 08/2005)
5.	Noda, Yukihiro: 8 articles (02/2015 - 12/2005)
6.	Pålsson, Erik: 8 articles (12/2010 - 11/2006)
7.	Svensson, Lennart: 8 articles (12/2009 - 02/2004)
8.	Meltzer, Herbert Y: 7 articles (02/2016 - 05/2003)
9.	Plath, Niels: 7 articles (11/2015 - 01/2010)
10.	Mouri, Akihiro: 7 articles (02/2015 - 12/2005)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 07/01/2011 - "While group II agonists are effective in several animal models of schizophrenia, they are reported to lack efficacy in moderating the effects of phencyclidine (PCP) on prepulse inhibition of acoustic startle in animal models of sensory processing deficits found in this disorder. " 01/01/2013 - "Phencyclidine-induced hypermotility in mice and inhibition of conditioned avoidance response in rats were assessed to estimate efficacy against the positive and social withdrawal test in rats was used to predict efficacy against the negative symptoms of schizophrenia. " 09/01/2012 - "Several compounds demonstrated efficacy in animal models of schizophrenia, including conditioned avoidance response and a pro-psychotic phencyclidine hyperactivity model." 04/01/2015 - "To study cognitive enhancement- and neuroprotective-effects of Brahmi on novel object recognition task and cerebral VGLUT2 immunodensity in sub-chronic phencyclidine (PCP) rat model of schizophrenia. " 03/01/2015 - "The objective of this study was to determine the effects of Brahmi on attenuation at cognitive deficit and on the neuronal density in the prefrontal cortex, striatum and cornu ammonis subfield 1 (CA1) and 2/3 (CA2/3) of hippocampus in sub-chronic phencyclidine (PCP) rat model of schizophrenia. "
2.	Seizures (Seizure) 12/01/1983 - "The present work deals with an EEG and behavioral study of the effect of phencyclidine against the convulsions due to pentylentetrazol in rats and rabbits. " 11/05/2004 - "The involvement of the septohippocampal system on the impaired sensorimotor gating induced by phencyclidine (PCP) or by an electrically induced hippocampal seizure was examined in behaving rats. " 11/05/2004 - "The medial septum mediates impairment of prepulse inhibition of acoustic startle induced by a hippocampal seizure or phencyclidine." 12/01/1983 - "An EEG investigation on the effects of phencyclidine on pentylentetrazol convulsions in rats and rabbits." 06/01/1982 - "Phencyclidine (PCP) has been reported to have both anesthetic and seizure-inducing properties. "
3.	Memory Disorders (Memory Loss) 03/01/2012 - "Preclinical studies indicate improved spatial working memory and reversal of phencyclidine-induced learning and memory deficits. " 01/01/2007 - "The drug reversed (MED: 0.3 mg/kg) selective attention impaired by neonatal phencyclidine (PCP) treatment and restored MK-801- or PCP-induced memory deficits in the Morris or linear maze (MED: 1-3 mg/kg). " 02/01/1984 - "If the inhibition observed in the brain homogenate occurs in vivo it may account for the high incidence of memory loss reported with phencyclidine use." 09/01/2010 - "Consistent with glutamatergic abnormality in schizophrenia, the NDMA receptor antagonist, phencyclidine (PCP), induces persistent 'schizophrenia-like' symptoms including memory deficits in humans and rodents and is widely used as an animal model of the disorder. " 02/15/2016 - "GLYX-13 (rapastinel) ameliorates subchronic phencyclidine- and ketamine-induced declarative memory deficits in mice."
4.	Amphetamine-Related Disorders (Addiction, Amphetamine) 05/01/2005 - "Further testing will be required to verify the efficacy of the test in populations with a higher prevalence of phencyclidine and amphetamine abuse." 01/01/1986 - "Open clinical trials have suggested that desipramine may be an effective agent for treatment of phencyclidine (PCP) or amphetamine dependence. " 01/01/1986 - "Double-blind comparison of desipramine and placebo for treatment of phencyclidine or amphetamine dependence."
5.	Catalepsy 08/15/2015 - "Albeit within a narrow dose range, Lu AF33241 attenuated sub-chronic phencyclidine-induced deficits in novel object recognition (3 and 10mg/kg), displayed antipsychotic-like activity in the conditioned avoidance response paradigm (10mg/kg), and did not induce catalepsy within a dose-range of 2-6mg/kg. Further catalepsy studies are needed to investigate a predictive safety window. " 12/01/1990 - "However, a dose of 160 mg/kg, i.m., was required to produce phencyclidine-like catalepsy in pigeons. " 11/27/1984 - "Phencyclidine-induced catalepsy in pigeons: specificity and stereoselectivity." 12/01/1983 - "However, this neurochemical effect of phencyclidine could not be related in any simple way to the immobility, stereotypy or catalepsy caused by this drug." 02/12/1999 - "Although these results conflict with those of a previous study which found that nitric oxide synthase inhibitors substituted for phencyclidine and produced phencyclidine-like catalepsy in pigeons, they are consistent with research showing that these drugs did not produce phencyclidine-like pharmacological effects in behavioral procedures in rats."

Related Drugs and Biologics

1.	Dizocilpine Maleate (Dizocilpine)
2.	N-Methylaspartate (NMDA)
3.	Ketamine
4.	piperidine
5.	Soman
6.	Amphetamine (Amfetamine)
7.	Dopamine (Intropin)
8.	Cocaine (Cocaine HCl)
9.	Ligands
10.	Desipramine (Pertofrane)

Related Therapies and Procedures

1.	Self Administration (Administration, Self)
2.	Oral Administration
3.	Analgesia
4.	Transplantation (Transplant Recipients)
5.	Therapeutics