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Pharyngeal Neoplasms

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Tumors or cancer of the PHARYNX.

Also Known As:

Cancer of the Pharynx; Neoplasms, Pharyngeal; Neoplasms, Pharynx; Pharnyx Cancer; Pharynx Neoplasms; Cancer, Pharnyx; Cancer, Pharyngeal; Cancers, Pharnyx; Cancers, Pharyngeal; Neoplasm, Pharyngeal; Neoplasm, Pharynx; Pharnyx Cancers; Pharyngeal Cancers; Pharyngeal Neoplasm; Pharynx Cancer; Pharynx Cancers; Pharynx Neoplasm; Cancer of Pharynx; Pharyngeal Cancer

Networked: 231 relevant articles (10 outcomes, 32 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Laryngeal Neoplasms (Laryngeal Cancer)
2.	Nasal Obstruction
3.	Pain (Aches)
4.	Neoplasms (Cancer)
5.	Prostatic Neoplasms (Prostate Cancer)

Experts

1.	Levi, F: 7 articles (06/2015 - 04/2000)
2.	La Vecchia, C: 7 articles (06/2015 - 04/2000)
3.	La Vecchia, Carlo: 6 articles (02/2015 - 05/2005)
4.	Negri, E: 5 articles (08/2014 - 04/2000)
5.	Franceschi, S: 5 articles (09/2009 - 04/2000)
6.	Bosetti, C: 4 articles (06/2015 - 04/2000)
7.	Talamini, Renato: 4 articles (02/2015 - 08/2007)
8.	Chen, Ping-Ho: 4 articles (01/2015 - 01/2013)
9.	Franceschi, Silvia: 4 articles (05/2010 - 05/2005)
10.	Hollenbeak, Christopher S: 3 articles (12/2015 - 05/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pharyngeal Neoplasms:

1.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 12/01/2006 - "Thirty patients with relapse nasal pharyngeal cancer were randomly divided into PDT group and chemotherapy group. " 01/01/1996 - "After PDT, 12 of 15 laryngeal cancer patients were classified as having a complete remission (CR), as were 2 of the 5 lingual or oral and one of the 4 pharyngeal cancer patients. " 01/01/1996 - "All 24 patients had squamous cell carcinoma: 15 with laryngeal, 5 with lingual or oral, and 4 with pharyngeal cancer and were treated by PDT. " 12/01/2006 - "To evaluate the clinical response and adverse effects of Photofrin photodynamic therapy (PDT) in patients with relapse nasal pharyngeal cancer. " 12/01/2006 - "This pilot study suggests that Photofrin PDT is effective and safe in treatment of advanced nasal pharyngeal cancer and management of nasal obstruction."
2.	Folic Acid (Vitamin M)FDA LinkGeneric 09/01/2005 - "The tetrazolium dye method (MTT assay) using human pharyngeal cancer cells (KB cell) revealed that FMA significantly improved cell growth inhibitory activity in spite of a short exposure time due to the selective and strong interaction between folate molecules and their receptors. " 02/15/2015 - "There are suggestions of an inverse association between folate intake and serum folate levels and the risk of oral cavity and pharyngeal cancers (OPCs), but most studies are limited in sample size, with only few reporting information on the source of dietary folate. " 03/01/2012 - "Folate consumption is inversely associated with the risk of oral and pharyngeal cancer (OPC) and potentially interacts with alcohol drinking in the risk of OPC. " 01/01/2009 - "The modified MNPs were internalized by human pharyngeal cancer cells (KB cells) after an incubation time that was short compared with the time required for internalization of MNPs without folic acid. " 11/01/2003 - "Folate intake and risk of oral and pharyngeal cancer."
3.	Ascorbic Acid (Vitamin C)FDA LinkGeneric 10/15/1989 - "The results of our study suggest that intake of vitamin C may be protective against pharyngeal cancer, and are consistent with the results of previous studies which reported a decreased risk of pharyngeal cancer associated with intake of fruits and vegetables." 03/01/1984 - "The reduction in risk with greater fruit and vegetable consumption is consistent with the hypothesis that vitamin C and/or beta-carotene intake is associated with a reduced risk of oral and pharyngeal cancer." 10/15/1989 - "A population-based case-control study was conducted to examine the effect of ingestion of vitamin C, carotenoids and retinol on risk of pharyngeal cancer. " 09/01/1997 - "Case-control studies have reported an inverse association between bladder cancer and vitamin C; oral/pharyngeal cancer and several supplemental vitamins; and several cancers and vitamin E. " 10/15/1989 - "Odds ratios (ORs) relating consumption of vitamin C, carotenoids and retinol from foods and vitamins C and A from supplements to risk of pharyngeal cancer were calculated using multiple logistic regression analysis. "
4.	MisonidazoleIBA 05/01/1996 - "The Danish misonidazole trial (626 patients) showed no overall benefit, however positive results were observed in a subgroup (304 pharyngeal cancer patients). "
5.	Dihematoporphyrin Ether (Porfimer Sodium)FDA Link 12/01/2006 - "To evaluate the clinical response and adverse effects of Photofrin photodynamic therapy (PDT) in patients with relapse nasal pharyngeal cancer. " 12/01/2006 - "This pilot study suggests that Photofrin PDT is effective and safe in treatment of advanced nasal pharyngeal cancer and management of nasal obstruction."
6.	PicibanilIBA 06/01/1988 - "In cases of pharyngeal cancer, the 3-year survival rate was 58% in both groups and the disease-free interval rates for up to 3 years after the fundamental therapy was 49% in the OK-432 + 5-FU group and 52% in the 5-FU group. "
7.	Morphine (MS Contin)FDA LinkGeneric 01/01/1995 - "A 47-year-old woman suffered from a pharyngeal cancer causing pain only poorly relieved by high doses of oral morphine. "
8.	Fluorouracil (Carac)FDA LinkGeneric 06/01/1988 - "In cases of pharyngeal cancer, the 3-year survival rate was 58% in both groups and the disease-free interval rates for up to 3 years after the fundamental therapy was 49% in the OK-432 + 5-FU group and 52% in the 5-FU group. "
9.	olive oilIBA 09/01/2012 - "Diets rich in fruits and vegetables, cereals, and olive oil confer protection against oral/pharyngeal cancer, whereas foods rich in animal products such as dairy and meat increase the risk for the disease."
10.	DNA (Deoxyribonucleic Acid)IBA 08/01/2011 - "The purpose of the present study was to highlight the role of DNA methyltransferase 1 (DNMT1) and its potential for improving treatment and informing prognosis for pharyngeal cancer. " 11/01/2011 - "Genomic detection of HPV DNA in the nuclei of certain oro-pharyngeal cancer cells gives strong evidence of a viral etiology in HNSCC. " 08/01/2011 - "Role of DNA methyltransferase 1 in pharyngeal cancer related to treatment resistance." 03/01/2008 - "Using both direct genomic DNA sequencing and novel mutant-enriched sequencing methods developed specifically for the 3 hot-spot mutations (H1047R, E545K and E452K) of PIK3CA, we detected 5 mutations of PIK3CA in the 24 pharyngeal cancers (20.8%). " 03/31/1999 - "As part of a hospital-based case-control study performed in France among Caucasian smokers, we studied GSTM1, GSTM3, GSTP1 and GSTT1 gene polymorphisms in 121 patients with oral cavity and pharyngeal cancers and 172 hospital controls using peripheral blood DNA. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 06/01/2004 - "Thus, the efficacy of chemotherapy are reviewed and treatment options for advanced pharyngeal cancer are made. " 12/01/1999 - "The present study shows a trend favoring p53 overexpression as a predictive and prognostic factor in locally advanced pharyngeal cancer treated with induction chemotherapy." 07/01/2015 - "Patients who received chemotherapy accumulated a mean of $26,919 (95% CI, $18,309-$35,056) and $37,407 (95% CI, $29,971-$44,644) more in costs by 5 years for oral cavity and pharyngeal cancers, respectively. " 05/01/2015 - "Similar results were found for pharyngeal cancers for stage (pd = 0.04; 95% CI, 0.01-0.06), treatment with chemotherapy and radiation (pd = 0.04; 95% CI, 0.01-0.07), and 1-year survival (pd = 0.01; 95% CI, 0.08-0.16). " 01/01/2013 - "Twenty patients with pharyngeal cancers treated with two-step IMRT combined with chemotherapy were included. "
2.	Free Tissue Flaps 03/01/2010 - "Study of the length of hospital stay for free flap reconstruction of oral and pharyngeal cancer in the context of the new French casemix-based funding." 05/01/2006 - "Swallowing after free-flap reconstruction in patients with oral and pharyngeal cancer." 04/01/2006 - "During the last 10 years, we have performed 43 circumferential pharyngoesophageal resection for advanced hypo-pharyngeal cancer followed by reconstruction with a free flap of jejunum. " 03/01/2006 - "Quality of life after free-flap reconstruction in patients with oral and pharyngeal cancer." 04/01/2001 - "Free flap reconstructions in the management of oral and pharyngeal cancer."
3.	Glossectomy 10/01/2011 - "Our results in a relatively large sample of patients who underwent total or subtotal glossectomy followed by reconstruction with microsurgical free flaps support the efficacy of this surgery as treatment for advanced oral and oral pharyngeal cancers."
4.	Radiotherapy 05/01/2013 - "The aim of this study was to determine changes in saliva flow and susceptibility to erosive challenges in pharyngeal cancer patients before and after radiotherapy to the head and neck. " 08/01/2012 - "The aim of the study was to investigate the predictive role of pretreatment metabolic volume (MTV) in pharyngeal cancer (PC) patients treated with definitive (chemo) radiotherapy. " 05/01/2007 - "Our study confirmed a poor outcome was associated with RPN involvement in patients with CT-based node-positive pharyngeal cancer and NNP patients definitively treated by radiotherapy." 01/01/2007 - "We invited all recurrence free patients, treated with radical radiotherapy for pharyngeal cancer between 1998 and 2002 at our institution, to participate in the study. " 01/01/2004 - "The purpose of this study was to evaluate the ultimate neck control after primary radiotherapy and surgical salvage in laryngeal and pharyngeal cancer patients. "
5.	Neck Dissection (Radical Neck Dissection) 07/01/2009 - "Prospective study on neck dissection after primary chemoradiation therapy in stage IV pharyngeal cancer." 02/01/2002 - "Topographical analysis of lymphatic pathways from the meso- and hypopharynx based on minute cadaveric dissections: possible application to neck dissection in pharyngeal cancer surgery." 05/01/1999 - "The objective of this study was to evaluate retrospectively treatment results in pharyngeal cancers presenting with N2-N3 neck disease, using neck dissection followed by radical locoregional radiotherapy (RT) and to compare these results with those obtained in patients treated by radical RT alone. " 12/01/1999 - "Recent studies demonstrate that elective neck dissection is beneficial to the outcome of oral cancer patients, but not necessarily to laryngeal and pharyngeal cancer patients. "