Phalloidine

Very toxic polypeptide isolated mainly from AMANITA phalloides (Agaricaceae) or death cup; causes fatal liver, kidney and CNS damage in mushroom poisoning; used in the study of liver damage.

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Networked: 196 relevant articles (7 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lue, Tom F: 2 articles (02/2015 - 10/2011)
2.	Lin, Guiting: 2 articles (02/2015 - 10/2011)
3.	Roy, Syamal: 2 articles (12/2014 - 06/2014)
4.	Fu, Ying-Xiao: 2 articles (04/2014 - 06/2013)
5.	Liu, Xue-Zhong: 2 articles (04/2014 - 06/2013)
6.	Liu, Zong-Ping: 2 articles (04/2014 - 06/2013)
7.	Yuan, Yan: 2 articles (04/2014 - 06/2013)
8.	Gu, Jian-Hong: 2 articles (04/2014 - 06/2013)
9.	Bian, Jian-Chun: 2 articles (04/2014 - 06/2013)
10.	Lu, Hong: 2 articles (01/2012 - 05/2008)

Related Diseases

1.	Poisoning 06/01/1981 - "This protection against phalloidin poisoning is correlated with the rate of the toxin uptake by the liver. " 02/01/1987 - "This substance is, however, not useful for such studies since the mechanism of phalloidin poisoning is too specific for interpretation in the sense of general liver protection." 01/01/1973 - "[Proceedings: Electron microscopy studies of the liver-cell membrane in phalloidine poisoning]." 01/01/1967 - "[Electron microscopic studies on the mouse and rat livers in acute phalloidin poisoning]." 06/01/1996 - "[Incidence and current treatment of cytotoxic cyclopeptide (phalloidine) poisoning in pregnant women]."
2.	Cholestasis 08/01/2000 - "In this study, the effect of phalloidin-induced cholestasis on bile lipid composition and liver subcellular membrane fraction composition in rats was examined to clarify the relationship between cholestasis and hepatic lipid metabolism. " 03/01/1996 - "To study the relationship between the dynamic actin web and bile secretion, we developed an acute model of cholestasis, using phalloidin, and examined sequential morphologic and biochemical events in rat liver. " 02/01/1996 - "In this study, the possible role of the hepatic microcirculation in phalloidin-induced cholestasis and hepatotoxicity was examined in isolated perfused rat livers (IPRL). " 08/15/2009 - "In BALU-1-treated animals, phalloidin-induced cholestasis was partially prevented. " 08/15/2009 - "Phalloidin causes severe liver damage characterized by marked cholestasis, which is due in part to irreversible polymerization of actin filaments. "
3.	Edema 07/01/2009 - "Tissue buttons from 31 corneas with stromal edema and 8 normal corneas were fixed, and 3-mm(2) blocks were cut and stained with phalloidin, to visualize the cytoskeleton. " 10/01/1994 - "Treatment with phalloidin or HSD prevented edema formation and attenuated the reduction in the number of patent capillaries per fiber (1.62 +/- 0.2 and 1.71 +/- 0.2, respectively) induced by I-R, whereas administration of MAb IB4 after the formation of edema in reperfused muscles failed to limit capillary no-reflow (0.5 +/- 0.1 patent capillaries/fiber).(ABSTRACT TRUNCATED AT 250 WORDS)" 03/01/1991 - "Phalloidin significantly attenuated edema in lung and reduced BAL protein leak. " 12/01/1990 - "Attenuation of acid aspiration edema with phalloidin." 09/01/1989 - "When the same protocol was repeated with phalloidin present in the medium throughout the experiment, the structural integrity of the endothelial cells was completely preserved and pericyte shrinkage was abolished, but interstitial space edema still occurred. "
4.	Hepatocellular Carcinoma (Hepatoma) 12/01/1978 - "When the same procedure was carried out with AS-30D hepatoma cells, and aliquots of the supernatants were tested with hepatocytes no marked decrease of the phalloidin response was seen. " 11/01/1996 - "Microinjection of C2 toxin or of phalloidin into hepatocyte-hepatoma hybrid cells had the same effects on actin synthesis as incubation with either toxin in the culture medium. " 12/01/1978 - "In contrast to normal liver cells, AS-30D hepatoma cells are insensitive to phalloidin. " 12/01/1978 - "A possible reason for the phalloidin tolerance of hepatoma cells." 12/01/1977 - "Different response to phalloidin in rats with various hepatomas."
5.	Anoxia (Hypoxia) 09/01/1989 - "We concluded that although phalloidin does not improve the capillary barrier of the normal rete, it provides protection against the structural and functional damage induced by hypoxia and reperfusion." 03/01/1994 - "Phalloidin (10(-6) mol/L), which stabilizes microfilaments and is able to penetrate these hypoxic cells, decreased the percentage of cells showing morphologic changes with hypoxia to < 5% by 90 minutes (p < 0.01). " 01/01/2012 - "There was disarrangement of intracellular filament actin by phalloidin staining, a 30% weaker fluorescence intensity by podocin staining, significantly reduced expression of synaptopodin (12%), CD2AP (42%), NcK (38%), and increased expression of TGF-β1 and P-ERK after hypoxia treatment. " 03/01/2008 - "Phalloidin staining demonstrated depolymerization of F-actin stress fibers and highly polarized F-actin patterns in endothelial cells under hypoxia. " 01/01/2003 - "Phalloidin, a microtubule stabilizer, prevented hypoxia-induced inhibition of NMDA DeltaCa(2+) in P3-10 neurons. "

Related Drugs and Biologics

1.	antamanide
2.	DAPI
3.	Cholesterol
4.	Maltose-Binding Proteins
5.	Lectins
6.	Actins (F Actin)
7.	Fluorescein-5-isothiocyanate (FITC)
8.	Cytochalasin D
9.	Rhodamines
10.	Dextrans (Dextran)

Related Therapies and Procedures

1.	Electrodes (Electrode)
2.	Ligation
3.	Lasers (Laser)
4.	Quantum Dots (Quantum Dot)
5.	Lenses