Pertussis Vaccine

A suspension of killed Bordetella pertussis organisms, used for immunization against pertussis (WHOOPING COUGH). It is generally used in a mixture with diphtheria and tetanus toxoids (DTP). There is an acellular pertussis vaccine prepared from the purified antigenic components of Bordetella pertussis, which causes fewer adverse reactions than whole-cell vaccine and, like the whole-cell vaccine, is generally used in a mixture with diphtheria and tetanus toxoids. (From Dorland, 28th ed)

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Networked: 1373 relevant articles (92 outcomes, 170 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Halperin, Scott A: 26 articles (12/2021 - 05/2002)
2.	Centers for Disease Control and Prevention (CDC): 23 articles (02/2015 - 03/2001)
3.	Locht, Camille: 12 articles (06/2022 - 02/2003)
4.	Klein, Nicola P: 11 articles (01/2022 - 07/2010)
5.	He, Qiushui: 10 articles (12/2022 - 07/2004)
6.	Singleton, James A: 10 articles (08/2022 - 08/2014)
7.	Decker, Michael D: 10 articles (10/2020 - 03/2006)
8.	Elam-Evans, Laurie D: 10 articles (08/2020 - 08/2014)
9.	Yankey, David: 10 articles (08/2020 - 08/2014)
10.	Greenberg, David P: 9 articles (10/2020 - 10/2005)

Related Diseases

1.	Whooping Cough (Pertussis) 01/01/2019 - "Whole-cell pertussis vaccine (wP) has been imperative and highly effective in preventing childhood deaths due to pertussis. " 12/01/2006 - "Administering all 5 doses of pertussis vaccine and the fifth dose at age 5 years with at least 36 months between the fourth and fifth doses provided the best protection against pertussis among children and adolescents in this outbreak." 07/15/2002 - "Thus, even after partial vaccination, acellular pertussis vaccine is highly effective in preventing hospitalizations for pertussis." 01/01/1991 - "These findings suggest that, since its introduction, the whole-cell pertussis vaccine produced in South Africa has been highly effective in controlling whooping cough. " 05/01/1985 - "The incidence of pertussis has been dramatically reduced in many areas of the world over the past 25 years by the use of pertussis vaccine. "
2.	Diphtheria 12/01/1990 - "The subjects consisted of 56 volunteers (20-31 years of age) who had received regular inoculations of diphtheria and pertussis vaccine (I and II or III phases). " 01/01/1962 - "[The morphology of the vaccination process in guinea pigs inoculated with diphtheriapertussis, pertussis vaccine and diphtheria anatoxin]." 12/01/2018 - "Immunogenicity and protective efficacy of a newly developed tri-component diphtheria, tetanus, and acellular pertussis vaccine in a murine model." 01/01/2017 - "Assessment of safety and efficacy against Bordetella pertussis of a new tetanus-reduced dose diphtheria-acellular pertussis vaccine in a murine model." 11/01/2023 - "Immunogenicity and safety of BPZE1, an intranasal live attenuated pertussis vaccine, versus tetanus-diphtheria-acellular pertussis vaccine: a randomised, double-blind, phase 2b trial."
3.	Tetanus 01/01/2017 - "Over two fifths (44%) of all AEFI occurred after the booster dose of the combined diphteria, tetanus and pertussis vaccine in 5-year old children. " 07/18/2013 - "However, the WHO-estimated immunization coverage of 88% for 3 doses of Diptheria-Tetanus-Pertussis vaccine in Pakistan is likely an over-estimate. " 01/01/2013 - "HEU demonstrated stronger pertussis vaccine responses, developing protective titers 1 year earlier than HUU patients, and maintained higher anti-tetanus titers at 24 months of age. " 02/03/2007 - "Pneumococcal vaccination at the rate of diptheria-tetanus-pertussis vaccine coverage was projected to prevent 262,000 deaths per year (7%) in children aged 3-29 months in the 72 developing countries studied, thus averting 8.34 million disability-adjusted life years (DALYs) yearly. " 12/01/2003 - "All monkeys were inoculated with diptheria, tetanus, and acellular pertussis vaccine at 5 weeks of age to simulate human infant vaccination schedules. "
4.	Infections 05/15/2011 - "Finally, using a murine respiratory infection model, we demonstrated that LT can act as a highly effective adjuvant for a pertussis vaccine, promoting Ag-specific Th17 cells and protection against Bordetella pertussis challenge, which was significantly reduced in IL-17-defective mice. " 09/01/2012 - "Understanding the immune responses that explain why infants require multiple doses of pertussis vaccine to achieve protection against infection is a high priority. " 12/01/2010 - "However, this decrease exists only for Bordetella pertussis infections, as the incidence of Bordetella parapertussis confirmed cases has remained stable, suggesting that pertussis-vaccine-induced immunity is not protective against parapertussis, as expected. " 01/01/2018 - "With the aim of providing protection against both disease and infection, a live attenuated pertussis vaccine, in which three toxins have been genetically inactivated or removed, is now in clinical development. " 08/01/1998 - "The efficacy of a whole cell pertussis vaccine and fimbriae against Bordetella pertussis and Bordetella parapertussis infections in respiratory mouse model."
5.	Cough 03/01/2000 - "To assess the diagnostic sensitivity and specificity of a Bordetella pertussis polymerase chain reaction (PCR) assay using nasopharyngeal (NP) specimens from subjects with cough illnesses participating in a large pertussis vaccine efficacy trial. " 10/01/1995 - "In a large pertussis vaccine efficacy trial in Germany, vaccinees and/or their family members were seen if a cough illness of >14 days was reported. " 04/01/1994 - "In conjunction with a pertussis vaccine efficacy trial in Germany, nasopharyngeal specimens were collected from May, 1992, to March, 1993, from patients with cough illnesses. " 10/01/2006 - "Between 1 January and 30 June 2005 we performed serological investigations in 139 children presenting with an irritable cough or after application of an acellular pertussis vaccine. " 08/01/2005 - "Pertussis vaccine doses among case children were counted as valid if they were received > or =14 days before the cough onset date ("valid period"). "

Related Drugs and Biologics

1.	Vaccines
2.	Toxoids
3.	Diphtheria-Tetanus-acellular Pertussis Vaccines (Tripedia)
4.	Antigens
5.	pertussis toxoid
6.	Antibodies
7.	Tetanus Toxoid (Vaccine, Tetanus)
8.	Conjugate Vaccines
9.	Proteins (Proteins, Gene)
10.	Acellular Vaccines

Related Therapies and Procedures

1.	Prenatal Care (Care, Prenatal)
2.	Injections
3.	Chemoprevention
4.	Subcutaneous Injections
5.	Contraindications