Persistent Fetal Circulation Syndrome

A syndrome of persistent PULMONARY HYPERTENSION in the newborn infant (INFANT, NEWBORN) without demonstrable HEART DISEASES. This neonatal condition can be caused by severe pulmonary vasoconstriction (reactive type), hypertrophy of pulmonary arterial muscle (hypertrophic type), or abnormally developed pulmonary arterioles (hypoplastic type). The newborn patient exhibits CYANOSIS and ACIDOSIS due to the persistence of fetal circulatory pattern of right-to-left shunting of blood through a patent ductus arteriosus (DUCTUS ARTERIOSUS, PATENT) and at times a patent foramen ovale (FORAMEN OVALE, PATENT).
Also Known As:
Circulation, Persistent Fetal; Persistent Fetal Circulation; Pulmonary Hypertension, Familial Persistent, of the Newborn; Fetal Circulation, Persistent; Hypertension, Pulmonary, of Newborn, Persistent; Persistent Pulmonary Hypertension of Newborn
Networked: 75 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Meconium Aspiration Syndrome
2. Sepsis (Septicemia)
3. Diaphragmatic Hernia
4. Pulmonary Hypertension (Ayerza Syndrome)
5. Respiratory Insufficiency (Respiratory Failure)


1. Dong, Ying: 1 article (09/2012)
2. Yu, Jia-Lin: 1 article (09/2012)
3. Yue, Guang: 1 article (09/2012)
4. Resch, Bernhard: 1 article (08/2012)
5. Müller, Wilhelm: 1 article (08/2012)
6. Hofer, Nora: 1 article (08/2012)
7. Lee, Shing Yan Robert: 1 article (08/2009)
8. Ling, Siu Cheung: 1 article (08/2009)
9. Li, Chi Keung: 1 article (08/2009)
10. Shiu, Yiu Keung: 1 article (08/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Persistent Fetal Circulation Syndrome:
1. Congenital diaphragmatic herniaIBA
2. Tolazoline (Priscoline)FDA Link
3. Nitric Oxide (Nitrogen Monoxide)FDA Link
4. OxygenIBA
5. Dopamine (Intropin)FDA LinkGeneric
6. Alprostadil (Muse)FDA LinkGeneric
7. Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
8. Indomethacin (Indometacin)FDA LinkGeneric
9. Epinephrine (Adrenaline)FDA LinkGeneric
10. Lactic AcidFDA LinkGeneric

Therapies and Procedures

1. Extracorporeal Membrane Oxygenation (ECMO)
2. Catheters
3. Neonatal Intensive Care
4. High-Frequency Ventilation
5. Continuous Positive Airway Pressure