Perphenazine (Trilafon)

01/01/1991 - "The efficacy of the treatment with perphenazine correlated with the forms of schizophrenia, predominant syndromes in the disease clinical picture, and different stages of the process by the treatment commencement. "
05/01/1960 - "Perphenazine (fentazin) in the management of chronic schizophrenia."
05/01/2014 - "The objective of this study was to evaluate the impact of once- versus twice-daily dosing of perphenazine, which has a plasma half-life of 8-12 hours, on clinical outcomes in patients with schizophrenia. "
01/01/2010 - "The goal of the study was to characterize population pharmacokinetics (PPK) for perphenazine in patients with schizophrenia from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE). "
01/01/2005 - "Until well conducted and reported randomised trials are undertaken clinicians will be in doubt as to the effects of perphenazine depots and people with schizophrenia should exercise their own judgement or ask to be randomised."

12/01/1997 - "On the day of surgery, both in and out-of hospital emesis were decreased by perphenazine. "
12/01/1997 - "There was less vomiting after perphenazine during the first 24 hr after surgery 42% (95% CI = 34%-50%) vs 57% (95% CI = 48%-66%, placebo), P < 0.01. "
01/01/1959 - "Value of perphenazine in control of postanaesthetic vomiting."
12/01/1997 - "The prophylactic administration of perphenazine decreases vomiting by children after tonsillectomy."
12/01/1997 - "To test the hypothesis that perphenazine decreases the incidence of vomiting by children after tonsillectomy. "

11/01/1958 - "The effect of trilafon on postanesthetic nausea, retching and vomiting; a controlled study."
02/01/2011 - "Post-operative nausea and vomiting prevention with perphenazine: long overdue."
04/01/1959 - "Effect of trilafon on nausea and vomiting during labor."
03/01/1958 - "Perphenazine in nausea and vomiting, and anxiety states."
06/01/1965 - "PERPHENAZIN (TRILAFON) IN THE PROPHYLAXIS OF NAUSEA AND VOMITING FOLLOWING ACUTE MYOCARDIAL INFARCT."

12/01/2010 - "there is evidence that perphenazine is effective in the prevention of PONV in children and adults without serious adverse effects compared with placebo."
12/01/2010 - "randomised controlled trials investigating the efficacy of perphenazine in the prevention of PONV in comparison with any other drug or placebo were systematically searched in MEDLINE, EMBASE, CINAHL and the Cochrane Library. "
12/01/2010 - "Efficacy of perphenazine to prevent postoperative nausea and vomiting: a quantitative systematic review."
04/19/1958 - "Trials of perphenazine in the prevention of postoperative vomiting."
04/01/2014 - "Given the infrequent side effects, this single, low dose of perphenazine should be encouraged as a low-risk adjunct to any multimodal PONV prophylaxis regimen, based on the selection criteria described."

01/01/1995 - "In this study of 45 elderly patients suffering from dementia and treated with perphenazine, 5 patients who were prospectively identified as poor P450 2D6 metabolizers had significantly greater side effects than the 40 extensive metabolizers."
01/01/1998 - "The authors found that fixed, low-dose neuroleptic treatment (0.15 mg/kg/day) for 10 days resulted in low perphenazine levels and low rates of acute response (25%) in elderly patients with primary psychotic illness (without dementia). "
01/01/1995 - "We examined the PRL response to intravenous perphenazine (PZ) in 11 elderly patients with psychotic symptoms complicating either a major depression (MD-P) or a dementia. "
10/01/1994 - "We examined the onset of NIP in 12 closely monitored, elderly psychiatric inpatients diagnosed with dementia being treated with perphenazine. "
03/01/2002 - "This double-blind, placebo-controlled study compared the acute efficacy of the selective serotonin reuptake inhibitor citalopram and the neuroleptic perphenazine with placebo for the treatment of psychosis and behavioral disturbances in nondepressed patients with dementia. "