Aggressive Periodontitis (Periodontosis)

Inflammation and loss of PERIODONTIUM that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as DENTAL PLAQUE and DENTAL CALCULUS. This highly destructive form of periodontitis often occurs in young people and was called early-onset periodontitis, but this disease also appears in old people.

Also Known As:

Networked: 843 relevant articles (25 outcomes, 188 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Chronic Periodontitis
2.	Aggressive Periodontitis (Periodontosis)
3.	Periodontitis
4.	Gingival Recession
5.	Gingivitis

Experts

1.	Xu, Li: 15 articles (10/2015 - 12/2004)
2.	Emingil, Gülnur: 13 articles (08/2014 - 09/2002)
3.	Shi, Dong: 12 articles (10/2015 - 12/2004)
4.	Atilla, Gül: 12 articles (08/2014 - 03/2004)
5.	Zhang, Li: 11 articles (10/2015 - 12/2004)
6.	Faveri, Marcelo: 9 articles (07/2015 - 09/2009)
7.	Feres, Magda: 9 articles (07/2015 - 09/2009)
8.	Eickholz, Peter: 9 articles (02/2015 - 12/2007)
9.	Berdeli, Afig: 9 articles (08/2014 - 04/2006)
10.	Schenkein, Harvey A: 9 articles (03/2013 - 01/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Aggressive Periodontitis:

1.	Tetracycline (Achromycin)FDA LinkGeneric 06/01/1988 - "The findings indicated that six weeks of systemic tetracycline therapy combined with supragingival plaque control was effective in the initial control of early juvenile periodontitis." 04/01/2003 - "The purpose of the present study was to evaluate the effects of tetracycline fibres (TCF) as an adjunct to scaling in the treatment of generalised aggressive periodontitis and to compare the effects with mechanical treatment only. " 07/01/1996 - "A double-blind trial of tetracycline in the management of early onset periodontitis." 10/01/1991 - "Our previous studies have demonstrated that early-identified lesions of localized juvenile periodontitis (LJP) can be treated by the use of systemically administered tetracycline alone (1 gm/day for 6 weeks). " 06/01/1988 - "The present study evaluated the effects of tetracycline therapy, with supragingival plaque control, on clinical attachment levels and radiographic bone height in patients with clinical and radiographic evidence of juvenile periodontitis. "
2.	Metronidazole (Metric)FDA LinkGeneric 01/01/2012 - "The purpose of this investigation was to evaluate the effect of local antibiotic therapy with metronidazole adjunctively to scaling and root planning (SRP) in the treatment of aggressive periodontitis. " 01/01/2012 - "Comparison of 1-periodontal indices and cultural porphyromonas gingivalis colony count in aggressive periodontitis patients treated by scaling and rootplanning with or without metronidazole gel." 03/01/1993 - "Metronidazole in the treatment of localized juvenile periodontitis." 01/01/1996 - "This 14-year longitudinal case study involved the treatment of localized juvenile periodontitis in a male patient commencing at 15 years of age, by scaling and root planing, systemic metronidazole, and subgingival curettage along with supervised maintenance. " 01/01/1996 - "A 14-year follow-up study of localized juvenile periodontitis treated by scaling and root planing, systemic metronidazole, and subgingival curettage: a case report."
3.	Amoxicillin (Wymox)FDA LinkGeneric 04/01/2006 - "Adjunctive metronidazole plus amoxicillin or metronidazole alone (when A.actinomycetemcomitans is not involved) is effective in deep pockets of aggressive periodontitis patients." 07/01/2010 - "Efficacy of amoxicillin and metronidazole combination for the management of generalized aggressive periodontitis." 06/01/2012 - "The aim of the present study is to evaluate the clinical and microbiologic changes resulting from non-surgical periodontal treatment associated with amoxicillin and metronidazole in individuals with aggressive periodontitis. " 07/01/2010 - "The aim of this study is to evaluate the effects of metronidazole-amoxicillin combination on clinical and microbiologic parameters in patients with generalized aggressive periodontitis. " 10/01/2007 - "The objective of this study was to explore the effect of incomplete adherence to the prescribed antibiotic regimen, amoxicillin and metronidazole, in the non-surgical treatment of generalized aggressive periodontitis (GAP). "
4.	Anti-Bacterial Agents (Antibiotics)IBA 12/01/2003 - "6. Improvements in mean AL were consistent for both chronic and aggressive periodontitis subjects, although the aggressive periodontitis patients benefited more from the antibiotics. " 07/01/2012 - "A manual and electronic search was made for human studies up to March 2011 that presented clinical and microbiological data for the efficacy of a systemic antibiotics in generalized aggressive periodontitis along with scaling and root planning. " 01/01/2015 - "We excluded studies of people with aggressive periodontitis, systemic disorders or who were taking antibiotics. " 07/01/2012 - "Because of the insufficient quantity and heterogenecity of studies, no adequate evidence could be gathered to use the beneficial effects of these antibiotics along with SRP in aggressive periodontitis compared with SRP alone." 07/01/2012 - "Role of antibiotics in generalized aggressive periodontitis: A review of clinical trials in humans."
5.	Doxycycline (Vibramycin)FDA LinkGeneric 06/01/1988 - "It was previously determined that surgery plus the antibiotic doxycycline were effective in eliminating or suppressing Actinobacillus actinomycetemcomitans (Aa), an organism strongly associated with disease in localized juvenile periodontitis (LJP). " 01/01/1990 - "A randomized, double-blind, placebo-controlled study on the immediate clinical and microbiological efficacy of doxycycline (100 mg for 14 days) was carried out to determine the benefit of adjunctive medication in 16 patients with localized juvenile periodontitis. " 01/01/1990 - "The immediate efficacy of adjunctive doxycycline in treatment of localized juvenile periodontitis." 01/01/1990 - "The long-term efficacy of systemic doxycycline medication in the treatment of localized juvenile periodontitis." 03/01/2013 - "The purpose of the present study was to evaluate the effect of a probiotic (Inersan®) alone, a combination of the probiotic with doxycycline and doxycycline alone on aggressive periodontitis patients. "
6.	Immunoglobulin G (IgG)IBA 01/01/2003 - "These experiments were prompted by our studies of localized juvenile periodontitis, a disease associated with high IgG2 production and a propensity of monocytes to differentiate into MDDC. " 10/18/2015 - "To analyze the serum IgG titers to Aggregatibacter actinomycetemcomitans(Aa) and associated factors in patients with aggressive periodontitis (AgP). " 10/18/2015 - "[Analysis of serum IgG titers to Aggregatibacter actinomycetemcomitans serotype c in aggressive periodontitis patients]." 10/01/2014 - "To evaluate the association among serum immunoglobulin G (IgG) responses to Aggregatibacter actinomycetemcomitans (Aa) serotypes a, b and c, Porphyromonas gingivalis (Pg), Tannerella forsythia (Tf) and clinical parameters in Aggressive Periodontitis (AP) subjects. " 10/01/2014 - "IgG sera levels against a subset of periodontopathogens and severity of disease in aggressive periodontitis patients: a cross-sectional study of selected pocket sites."
7.	moxifloxacin (Avelox)FDA Link 01/01/2015 - "Clinical Factors Influencing the Efficacy of Systemic Moxifloxacin in the Therapy of Patients With Generalized Aggressive Periodontitis: A Multilevel Analysis From a Clinical Trial." 02/01/2015 - "Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial." 01/01/2015 - "The objective of this multilevel analysis is to investigate clinical factors at subject and sites of the tooth that influence variations in clinical attachment (CAL) increase and probing depth (PD) diminution of adjunctive moxifloxacin (MOX) at six months post-treatment in generalized aggressive periodontitis. " 02/01/2015 - "The aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (MOX) in one-stage scaling and root planing (SRP) in treating generalized aggressive periodontitis (GAgP). " 07/01/2015 - "The objective of this randomized clinical study was to evaluate the effect of systemic administration of moxifloxacin compared to amoxicillin and metronidazole, combined with non-surgical treatment in patients with generalized aggressive periodontitis (GAgP) in a 6-month follow-up. "
8.	Immunoglobulin A (IgA)IBA 06/01/2003 - "In addition to these changes, periodontal treatment of aggressive periodontitis did not appear to affect salivary IgA, and there were no significant correlations of IgA to the clinical parameters. " 06/01/2003 - "Twenty-one patients with generalized aggressive periodontitis were monitored for total salivary IgA and IgA reactive to Porphyromonas gingivalis in resting and stimulated whole saliva. " 10/01/2002 - "In particular an IgA subclass 1-specific decrease in aggressive periodontitis was noted, while the bacteria-reactive humoral immune system in saliva was activated. " 10/01/2002 - "Although only minor differences were detected in the concentration and secretion of bacteria-reactive IgA in both groups, the proportion of bacteria-reactive IgA from the total IgA was significantly higher (P < 0.01) in the aggressive periodontitis group in all three microorganisms tested. " 10/01/2002 - "A statistically significantly lower concentration and secretion rate of total salivary IgA (P < 0.01) and IgA1 (P < 0.001) was found in the aggressive periodontitis group in resting and stimulated saliva. "
9.	Immunoglobulin M (IgM)IBA 01/01/1984 - "A significant difference was found in the mean IgM values in the juvenile periodontitis group when compared to the control group. " 10/01/1983 - "Serum IgM antibodies to LPS were increased in LJP, generalized juvenile periodontitis, and adult periodontitis patients compared to all other groups. " 06/01/1980 - "This study indicates that a significantly greater percentage of periodontosis patients had high serum IgM and IgA levels compared to the control subjects plus a trend in the same direction for IgG. Paradoxically, 41% of the periodontosis subjects had no elevation of IgG, IgA or IgM." 01/01/1995 - "The levels, specificity and avidities of serum IgM and IgG antibodies reactive with Actinobacillus actinomycetemcomitans (Aa) serotypes a, b and c were determined in periodontally healthy (PH) children and compared with subjects with localized juvenile periodontitis (LJP). " 06/01/1993 - "Seropositive early-onset periodontitis patients were sampled, and the Ig classes IgG, IgA, and IgM and subclasses IgG1, IgG2, IgG3, IgG4, IgA1, and IgA2 were studied. "
10.	AntigensIBA 03/01/2008 - "Human leukocyte antigen polymorphism in chronic and aggressive periodontitis among Caucasians: a meta-analysis." 12/01/2006 - "A case-control study on the association of human leukocyte antigen-A*9 and -B*15 alleles with generalized aggressive periodontitis in an Indian population." 06/01/1998 - "Using enzyme-linked immunosorbent assay (ELISA), sera from 36 patients with localized juvenile periodontitis were surveyed using whole-cell sonicate as plate antigen. " 06/01/1998 - "The dominant antigen of Actinobacillus actinomycetemcomitans recognized by high-titer sera from patients with localized juvenile periodontitis is the serotype antigen located in the O-side chains of lipopolysaccharide. " 06/01/1996 - "The presence of these antigens gives evidence as to the susceptibility of various forms of early onset periodontitis."

Therapies and Procedures

1.	Root Planing 06/01/1999 - "These findings suggest that a one stage full-mouth disinfection results in an improved clinical outcome for the treatment of chronic adult or early-onset periodontitis as compared to scaling and root planing per quadrant at 2-week intervals." 01/01/2013 - "Patients diagnosed with advanced chronic or aggressive periodontitis were included in the study, provided that they were ≤40 years of age at the initial examination and had undergone a non-surgical periodontal therapy (scaling and root planing). " 09/01/2007 - "The aim of this study was to test the hypothesis that there are no differences in clinical parameters in generalized aggressive periodontitis patients after full-mouth scaling and root planing (FRP) or quadrant-wise basic periodontal therapy (BPT) when combined with an antibiotic regimen. " 06/01/2005 - "The aim of the present study was to investigate the outcomes after different root planing intensities during ERP in 37 patients with aggressive periodontitis after SRP. " 04/01/2003 - "In conclusion, the clinical and microbiological data of the present study suggest that the adjunctive use of TCF improves the clinical response of scaling and root planing in aggressive periodontitis patients."
2.	Debridement 03/01/2004 - "More recently, SDD adjunctive to repeated mechanical debridement resulted in dramatic clinical improvement in patients (>50% smokers) with generalized aggressive periodontitis. " 03/01/2013 - "Clinical and microbiological effects of systemic antimicrobials combined to an anti-infective mechanical debridement for the management of aggressive periodontitis: a 12-month randomized controlled trial." 04/01/2011 - "Impact of systemic antimicrobials combined with anti-infective mechanical debridement on the microbiota of generalized aggressive periodontitis: a 6-month RCT." 08/01/1995 - "The objective of this study was to assess the effectiveness of surgical debridement versus various guided tissue regeneration techniques for the treatment of localized juvenile periodontitis (LJP). " 01/01/1989 - "Chemotherapy can represent a valuable adjunct to routine mechanical debridement, particularly for adult recurrent periodontitis, juvenile periodontitis and rapidly progressive periodontitis. "
3.	Transplants (Transplant) 09/01/1989 - "The results indicate all three graft materials used in conjunction with TTC are acceptable and beneficial for the treatment and repair of osseous defects associated with localized juvenile periodontitis." 09/01/2011 - "Long-term onlay graft volume maintenance in aggressive periodontitis patients." 01/01/2010 - "Management of infrabony defects in mandibular molars in a patient with generalized aggressive periodontitis using autogenous bone graft from maxillary tuberosity." 10/01/1984 - "[Autogenous tooth transplants to replace 1st molars in the treatment of juvenile periodontitis]." 04/01/1984 - "Juvenile periodontitis: healing following autogenous iliac marrow graft, long-term evaluation."
4.	Aftercare (After-Treatment) 12/01/2015 - "Lipid subclasses profiles and oxidative stress in aggressive periodontitis before and after treatment." 01/01/2012 - "[Comparative characteristics of oral microbiocenosis in patients with chronic generalized and aggressive periodontitis before and after treatment]." 12/01/2008 - "Persistence of extracrevicular bacterial reservoirs after treatment of aggressive periodontitis." 01/01/2007 - "Electron microprobe analysis was used to study the nature of the newly-formed hard tissue 3 years after treatment with guided tissue regeneration in a patient with localized aggressive periodontitis. " 01/01/1991 - "Studies were carried out in a group of 20 patients with juvenile periodontitis before, after treatment by scaling, root planing, oral hygiene instruction and 20 patients with healthy gingiva as a control group. "
5.	Photochemotherapy (Photodynamic Therapy) 06/01/2007 - "Antimicrobial photodynamic therapy in the non-surgical treatment of aggressive periodontitis: a preliminary randomized controlled clinical study." 03/01/2015 - "Antimicrobial photodynamic therapy as an adjunct to non-surgical treatment of aggressive periodontitis: a split-mouth randomized controlled trial." 01/01/2014 - "Clinical and Microbiological Effects of Photodynamic Therapy Associated with Non-surgical Treatment in Aggressive Periodontitis." 03/01/2012 - "Antimicrobial photodynamic therapy in the non-surgical treatment of aggressive periodontitis: microbiological profile." 01/01/2009 - "Antimicrobial photodynamic therapy in the non-surgical treatment of aggressive periodontitis: cytokine profile in gingival crevicular fluid, preliminary results."