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Familial Mediterranean Fever (Periodic Disease)

A group of HEREDITARY AUTOINFLAMMATION DISEASES, characterized by recurrent fever, abdominal pain, headache, rash, PLEURISY; and ARTHRITIS. ORCHITIS; benign MENINGITIS; and AMYLOIDOSIS may also occur. Homozygous or compound heterozygous mutations in marenostrin gene encoding PYRIN result in autosomal recessive transmission; simple heterozygous, autosomal dominant form of the disease also exists with mutations in the same gene.
Also Known As:
Periodic Disease; Mediterranean Fever, Familial; Wolff Periodic Disease; Benign Paroxysmal Peritonitis; Familial Mediterranean Fever, Autosomal Dominant; Familial Mediterranean Fever, Autosomal Recessive; Familial Paroxysmal Polyserositis; Periodic Peritonitis; Polyserositis, Familial Paroxysmal; Polyserositis, Recurrent; Recurrent Polyserositis; Benign Paroxysmal Peritonitides; Disease, Periodic; Disease, Wolff Periodic; Disease, Wolff's Periodic; Diseases, Periodic; Familial Paroxysmal Polyserositides; Paroxysmal Peritonitides, Benign; Paroxysmal Peritonitis, Benign; Paroxysmal Polyserositides, Familial; Paroxysmal Polyserositis, Familial; Periodic Disease, Wolff; Periodic Disease, Wolffs; Periodic Diseases; Periodic Peritonitides; Peritonitides, Benign Paroxysmal; Peritonitides, Periodic; Peritonitis, Benign Paroxysmal; Peritonitis, Periodic; Polyserositides, Familial Paroxysmal; Polyserositides, Recurrent; Recurrent Polyserositides; Wolffs Periodic Disease; Periodic Disease, Wolff's; Wolff's Periodic Disease
Networked: 1616 relevant articles (101 outcomes, 161 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Amyloidosis
2. Gout
3. Pericarditis
4. Fever (Fevers)
5. Familial Mediterranean Fever (Periodic Disease)

Experts

1. Livneh, Avi: 42 articles (04/2022 - 04/2003)
2. Ozen, Seza: 37 articles (12/2022 - 05/2003)
3. Lidar, Merav: 21 articles (04/2022 - 12/2003)
4. Kastner, Daniel L: 20 articles (01/2022 - 01/2003)
5. Migita, Kiyoshi: 19 articles (01/2022 - 05/2013)
6. Ben-Zvi, Ilan: 18 articles (04/2022 - 04/2011)
7. Kawakami, Atsushi: 17 articles (07/2022 - 05/2013)
8. Tufan, Abdurrahman: 15 articles (12/2022 - 10/2006)
9. Koga, Tomohiro: 15 articles (07/2022 - 04/2016)
10. Ozdogan, Huri: 15 articles (01/2022 - 07/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Familial Mediterranean Fever:
1. ColchicineFDA LinkGeneric
2. canakinumabFDA Link
3. Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link
4. Interleukin-1 (Interleukin 1)IBA
5. AA amyloidosisIBA
6. Interferon-alpha (Interferon Alfa)IBA
7. rilonaceptFDA Link
8. tocilizumab (atlizumab)FDA Link
9. Pharmaceutical PreparationsIBA
02/01/2017 - "Although renal transplant patients with associated amyloidosis-type familial Mediterranean fever and those with glomerulonephritis have similar rejection and/or graft loss rates, hospital admissions due to infection and increased mortality are more common in the familial Mediterranean fever group, with immunosuppression drug withdrawal."
01/01/2013 - "Beyond its present medicinal use (gout, familial Mediterranean fever, Behcet's disease, chondrocalcinosis and other crystal arthritis), numerous other conditions have been recently proposed for the use of this drug, including pericardial diseases. "
01/04/2005 - "Diseases that commonly masquerade as this condition include thrombophlebitis, contact dermatitis, insect stings, drug reactions, eosinophilic cellulitis (the Wells syndrome), gouty arthritis, carcinoma erysipelatoides, familial Mediterranean fever, and foreign-body reactions. "
09/01/2009 - "Federal Drug Administration for the treatment and prophylaxis of gout flares but has also been tried with varying success in the treatment of familial Mediterranean fever, primary biliary cirrhosis, psoriasis, Behçet's disease, aphthous stomatitis, linear IgA dermatosis, relapsing polychondritis, Sweet's syndrome, scleroderma, amyloidosis, leukocytoclastic vasculitis, epidermolysis bullosa, and dermatomyositis."
01/01/2020 - "This study aimed to investigate the benefit of changing the pharmaceutical preparation of colchicine in Turkish Familial Mediterranean Fever (FMF) patients resistant to one preparation in terms of frequency of the attacks. "
10. Infliximab (Remicade)FDA Link

Therapies and Procedures

1. Therapeutics
2. Biological Therapy
3. Bone Marrow Transplantation (Transplantation, Bone Marrow)
4. Tonsillectomy
5. Thyroidectomy