Tuberculous Pericarditis

INFLAMMATION of the sac surrounding the heart (PERICARDIUM) due to MYCOBACTERIUM TUBERCULOSIS infection. Pericarditis can lead to swelling (PERICARDIAL EFFUSION), compression of the heart (CARDIAC TAMPONADE), and preventing normal beating of the heart.

Also Known As:

Networked: 123 relevant articles (3 outcomes, 11 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Meningeal Tuberculosis (Tuberculous Meningitis)
2.	Anoxia (Hypoxia)
3.	Infection
4.	Bacterial Meningitis
5.	Typhoid Fever (Typhoid)

Experts

1.	Mayosi, Bongani M: 11 articles (01/2015 - 09/2003)
2.	Ntsekhe, Mpiko: 8 articles (12/2014 - 01/2006)
3.	Gumedze, Freedom: 4 articles (09/2014 - 01/2006)
4.	Magula, Nombulelo P: 4 articles (09/2014 - 09/2003)
5.	Commerford, Patrick J: 4 articles (01/2013 - 01/2006)
6.	Doubell, Anton F: 4 articles (09/2006 - 09/2002)
7.	Smieja, Marek: 3 articles (12/2014 - 02/2013)
8.	Awotedu, Abolade A: 3 articles (09/2014 - 01/2006)
9.	Mntla, Phindile: 3 articles (09/2014 - 01/2006)
10.	Aje, Akinyemi: 3 articles (09/2014 - 01/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Tuberculous Pericarditis:

1.	Adrenal Cortex Hormones (Corticosteroids)IBA 03/14/2008 - "These data provide a justification for the establishment of adequately powered randomised clinical trials to assess the effectiveness of adjunctive corticosteroids in patients with tuberculous pericarditis." 09/01/2006 - "The potential benefits from adjunctive corticosteroids in the management of effusive tuberculous pericarditis could not be demonstrated in this three-year study." 03/14/2008 - "There is controversy concerning the effectiveness of adjunctive corticosteroids in reducing mortality in tuberculous pericarditis. " 03/14/2008 - "Contemporary use of adjunctive corticosteroids in tuberculous pericarditis." 11/01/2006 - "The authors present a literature review on constrictive tuberculous pericarditis in human immunodeficiency virus seropositive and seronegative patients, discussing the role of corticosteroids and the contribution of different diagnostic tools."
2.	Streptomycin (Streptomycin Sulfate)FDA Link 07/06/1958 - "[Tuberculous pericarditis on the way to symphysic development cured by the medical combination of streptomycin & deltacortisone]." 11/01/1980 - "The presence of an antibody with specificity against streptomycin-sensitized red blood cells in the serum of a patient with tuberculous pericarditis is reported. " 12/01/1954 - "Tuberculous pericarditis: the effect of streptomycin." 04/01/1952 - "A presumptive case of tuberculous pericarditis treated with streptomycin." 03/01/1952 - "Tuberculous pericarditis; its treatment with streptomycin and some observations on the natural history of the disease."
3.	Adenosine DeaminaseIBA 11/01/2015 - "This study aims to summarize the overall diagnostic performance of adenosine deaminase for tuberculous pericarditis through a meta-analysis. " 11/01/2015 - "Many studies suggest that adenosine deaminase is a marker for tuberculous pericarditis, while controversy exists as to its diagnostic utility. " 11/01/2015 - "Adenosine deaminase is a valuable marker with both high sensitivity and specificity in the diagnosis of tuberculous pericarditis. " 11/01/2015 - "The summary estimates of adenosine deaminase for diagnosing tuberculous pericarditis were listed as follows: sensitivity of 0.90 (95% CI: 0.86-0.93), specificity of 0.86 (95% CI: 0.83-0.89), PLR of 5.90 (95% CI: 4.46-7.82), NLR of 0.15 (95% CI: 0.09-0.26), and DOR of 42.55 (95% CI: 21.51-84.18). " 11/01/2015 - "The data were retrieved and the sensitivity, specificity, positive/negative likelihood ratio (PLR/NLR), diagnostic odds ratio (DOR) of adenosine deaminase for diagnosing tuberculous pericarditis were pooled, and the summary receiver operating characteristic (SROC) curves were used to examine the overall performance of adenosine deaminase. "
4.	SteroidsIBA 08/01/2003 - "Steroids could have large beneficial effects on mortality and morbidity in tuberculous pericarditis, but published trials are too small to be conclusive. " 01/01/2002 - "Two trials with a total of 383 participants tested adjuvant steroids in participants with suspected tuberculous pericarditis in the pre-HIV era. " 08/01/2003 - "Three (total n = 411) tested adjuvant steroids in participants with suspected tuberculous pericarditis in the pre-HIV era. " 01/01/2011 - "We conclude that the tuberculous pericarditis diagnosis should be established by clinical suspicion, two-dimensional echocardiography and pericardiocentesis and later pericardiectomy must be practiced as soon as possible before receiving pharmacological treatment with triple drug therapy and steroids." 12/06/2005 - "Research is needed to improve the diagnosis, assess the effectiveness of adjunctive steroids, and determine the impact of HIV infection on the outcome of tuberculous pericarditis."
5.	Prednisolone (Predate)FDA LinkGeneric 08/01/2000 - "Double blind randomised placebo controlled trial of adjunctive prednisolone in the treatment of effusive tuberculous pericarditis in HIV seropositive patients." 11/01/2014 - "[Treating tuberculous pericarditis: prednisolone or mycobacteria therapy? " 09/18/2014 - "In patients with tuberculous pericarditis, neither prednisolone nor M. " 09/18/2014 - "Using a 2-by-2 factorial design, we randomly assigned 1400 adults with definite or probable tuberculous pericarditis to either prednisolone or placebo for 6 weeks and to either M. " 09/18/2014 - "Prednisolone and Mycobacterium indicus pranii in tuberculous pericarditis."
6.	InterferonsIBA 12/01/2008 - "This report documents the feasibility and clinical usefulness of an Interferon (IFN) - gamma ELISpot - TB assay on pericardial fluid cells in a case of suspected tuberculous pericarditis presenting with tamponade. " 12/01/2009 - "Additional markers, such as interferon and lysozyme, have also been suggested for the diagnosis of tuberculous pericarditis. " 01/01/2014 - "Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous pericarditis compared to adenosine deaminase and unstimulated interferon-γ in a high burden setting: a prospective study."
7.	Interferon-gamma (Interferon, gamma)IBA 09/01/2008 - "Interferon-gamma may be a better test for tuberculous pericarditis." 09/01/2002 - "The use of adenosine deaminase and interferon-gamma as diagnostic tools for tuberculous pericarditis." 05/01/2002 - "To evaluate cytokine production (interferon-gamma [IFN-gamma], interleukin-1 [IL-1], interleukin-2 [IL-2], interleukin-6 [IL-6], interleukin-10 [IL-10], interleukin-4 [IL-4] and tumour necrosis factor-alpha [TNF-alpha]) in patients with tuberculous pericarditis. "
8.	CortisoneIBA 04/01/1955 - "[Acute tuberculous pericarditis: the effect of cortisone]." 02/01/1954 - "[Two cases of tuberculous pericarditis treated with cortisone]." 10/28/1955 - "[Treatment of tuberculous pericarditis and cryptogenic pericarditis with ACTH and cortisone]."
9.	Carcinoembryonic AntigenIBA 11/01/1984 - "Elevated carcinoembryonic antigen in tuberculous pericarditis." 12/01/2009 - "High adenosine deaminase levels (ADA) and low levels of carcinoembryonic antigen (CEA) in the pericardial effusion are observed in tuberculous pericarditis allowing the differentiation from malignant pericardial effusion. " 06/01/1994 - "Adenosine deaminase and carcinoembryonic antigen in pericardial effusion diagnosis, especially in suspected tuberculous pericarditis."
10.	Interleukin-10 (Interleukin 10)IBA 01/01/2013 - "Effusive-constrictive disease occurs in half of cases of tuberculous pericardial effusion, and is characterized by greater elevation in the pre-pericardiocentesis right atrial pressure and pericardial and serum IL-10 levels compared to patients with effusive non-constrictive tuberculous pericarditis." 05/01/2002 - "To evaluate cytokine production (interferon-gamma [IFN-gamma], interleukin-1 [IL-1], interleukin-2 [IL-2], interleukin-6 [IL-6], interleukin-10 [IL-10], interleukin-4 [IL-4] and tumour necrosis factor-alpha [TNF-alpha]) in patients with tuberculous pericarditis. "

Therapies and Procedures

1.	Pericardiectomy 01/01/2003 - "We performed this study to determine the predictors of early and long-term survival in the surgical treatment of tuberculous pericarditis and to examine the risks of pericardiectomy and the functional outcome in patients after surgery. " 06/01/2012 - "The prevalence of ECP is low in non-tuberculous pericarditis, while pericardiectomy rates are high and mortality is variable. " 12/01/2011 - "The recurrence of constriction physiology after complete pericardiectomy in non-tuberculous pericarditis is a rarely reported in literature. " 06/01/2006 - "This retrospective study aimed to investigate risk factors and early and late outcomes of pericardiectomy for constrictive tuberculous pericarditis. " 06/01/2006 - "Chronic constrictive tuberculous pericarditis: risk factors and outcome of pericardiectomy."
2.	Drug Therapy (Chemotherapy) 08/01/2004 - "In the absence of a clear contraindication, a corticosteroid should be used in addition to antituberculosis chemotherapy in the management of patients with tuberculous pericarditis." 01/01/2003 - "A combination of chemotherapy and surgery yields gratifying results in the treatment of tuberculous pericarditis." 03/01/2002 - "Tuberculous pericarditis in an infant evolving during triple chemotherapy." 07/01/1996 - "Clinical progress of tuberculous pericarditis was investigated in patients receiving antituberculous chemotherapy. " 04/01/1989 - "12 patients with tuberculous pericarditis were studied by M-Mode echocardiography, before and after antituberculous chemotherapy. "
3.	Immunotherapy 12/25/2014 - "Immunotherapy for tuberculous pericarditis." 12/25/2014 - "Immunotherapy for tuberculous pericarditis." 12/25/2014 - "Immunotherapy for tuberculous pericarditis." 12/25/2014 - "Immunotherapy for tuberculous pericarditis." 12/25/2014 - "Immunotherapy for tuberculous pericarditis."
4.	Transplants (Transplant) 09/01/2007 - "Tuberculous pericarditis after coronary artery bypass graft."
5.	Therapeutics 12/01/1995 - "We reported four cases in which tuberculous pericarditis was the initial manifestation of AIDS, characterizing by its clinical picture, diagnostic methods, therapeutics and the evolution of this involvement."