Constrictive Pericarditis

Inflammation of the PERICARDIUM that is characterized by the fibrous scarring and adhesion of both serous layers, the VISCERAL PERICARDIUM and the PARIETAL PERICARDIUM leading to the loss of pericardial cavity. The thickened pericardium severely restricts cardiac filling. Clinical signs include FATIGUE, muscle wasting, and WEIGHT LOSS.

Also Known As:

Networked: 614 relevant articles (20 outcomes, 30 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Restrictive Cardiomyopathy
2.	Cardiac Tamponade
3.	Pulmonary Tuberculosis
4.	Rheumatoid Arthritis
5.	Syncope (Fainting)

Experts

1.	Oh, Jae K: 8 articles (09/2014 - 03/2002)
2.	Klein, Allan L: 6 articles (10/2015 - 02/2004)
3.	Schaff, Hartzell V: 6 articles (09/2014 - 01/2008)
4.	Seth, Sandeep: 3 articles (10/2015 - 02/2006)
5.	Alraies, M Chadi: 3 articles (10/2015 - 05/2013)
6.	Mayosi, Bongani M: 3 articles (01/2015 - 09/2014)
7.	Ha, Jong-Won: 3 articles (05/2011 - 11/2008)
8.	Umer, Affan: 2 articles (12/2015 - 01/2015)
9.	Spodick, David H: 2 articles (12/2015 - 01/2015)
10.	Chhabra, Lovely: 2 articles (12/2015 - 01/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Constrictive Pericarditis:

1.	Brain Natriuretic Peptide (Natrecor)FDA Link 12/01/2009 - "Plasma levels of brain natriuretic peptide increased significantly in both patients, allowing us to distinguish this disease from constrictive pericarditis which has similar clinical and hemodynamic features. " 12/01/2006 - "We report the case of a 35-year-old man with constrictive pericarditis who had a B-type natriuretic peptide (BNP) level of 129 pg/dl despite a left ventricular end diastolic pressure of 35 mmHg. " 12/01/2006 - "B-type natriuretic peptide level in a patient with constrictive pericarditis." 06/07/2005 - "The efficacy of brain natriuretic peptide levels in differentiating constrictive pericarditis from restrictive cardiomyopathy." 01/01/2015 - "NT pro B type natriuretic peptide levels in constrictive pericarditis and restrictive cardiomyopathy."
2.	tranilast (N 5')IBA 09/01/1993 - "Group 1 (with constrictive pericarditis; n = 5) had surgical confirmation of thickened pericardium and improved clinically after pericardiectomy. " 03/01/2005 - "Real-time cine MRI studies, using the steady-state free precession (SSFP) technique, were performed in the cardiac short-axis during operator-guided deep inspiration and expiration in normal volunteers (N = 6), and in patients with constrictive pericarditis (CP; N = 6), restrictive cardiomyopathy (RCM; N = 4), chronic cor pulmonale (N = 5), and pericardial effusion. " 01/01/1987 - "Patients with LV hypertrophy (n = 4), amyloid cardiomyopathy (n = 1), constrictive pericarditis (n = 5), and hypertrophic cardiomyopathy (n = 3) had absolute and percent systolic wall thickening within normal limits. "
3.	ColchicineFDA LinkGeneric 04/01/2012 - "Secondary end points were symptom persistence after 72 h, remission rate at 1 week, number of recurrences, time to first recurrence, disease-related hospitalizations,cardiac tamponade, and constrictive pericarditis rates.120 patients (60 in the colchicine and 60 in the placebo group) were included in the analysis. " 12/01/2007 - "Because constriction may be transient in a small proportion of patients, particularly those with exudative effusions, the initial treatment for constrictive pericarditis should be conservative, with loop diuretic therapy to manage volume expansion and edema and the use of colchicine, nonsteroidal anti-inflammatory agents, or, if necessary, glucocorticoid therapy for active inflammation. "
4.	Prednisone (Sone)FDA LinkGeneric 02/01/1992 - "Some patients with pulmonary tuberculosis or constrictive pericarditis have a better outcome when they are given prednisone. "
5.	Clozapine (Clozaril)FDA LinkGeneric 01/01/2007 - "We report a case of effuso-constrictive pericarditis soon after being started on clozapine therapy, whose symptoms improved after discontinuation of clozapine. " 01/01/2007 - "Clozapine-induced effuso-constrictive pericarditis. "
6.	Antifungal AgentsIBA 06/01/1998 - "We report a case of Candida purulent constrictive pericarditis in an immunocompromised heart transplant patient who was treated successfully with antifungal agents, surgical drainage, and pericardiectomy."
7.	Prednisolone (Predate)FDA LinkGeneric 12/19/1987 - "Controlled trial of prednisolone as adjuvant in treatment of tuberculous constrictive pericarditis in Transkei." 09/18/2014 - "Prednisolone therapy, as compared with placebo, was associated with significant reductions in the incidence of constrictive pericarditis (4.4% vs. 7.8%; hazard ratio, 0.56; 95% CI, 0.36 to 0.87; P=0.009) and hospitalization (20.7% vs. 25.2%; hazard ratio, 0.79; 95% CI, 0.63 to 0.99; P=0.04). " 08/01/2004 - "Two randomized trials showed benefits at two years for prednisolone in patients with constrictive pericarditis, and open drainage plus prednisolone in patients with pericardial effusion. "
8.	Idiopathic pulmonary hypertensionIBA 11/01/1958 - "[Pulmonary arterial hypertension in constrictive pericarditis; study of 7 cases]." 01/01/1978 - "An unusual type of displacement of interventricular septum, the inverse of that found normally, was found by echocardiography in 3 cases: 2 with pulmonary arterial hypertension and 1 with constrictive pericarditis. " 01/01/1983 - "There was no difference in radiopacity and the type and incidence of adverse reactions were similar, but the frequency was significantly higher (p less than 0.05) with Vascoray in patients with constrictive pericarditis, dissecting aortic aneurysm, and primary pulmonary hypertension. "
9.	RNA (Ribonucleic Acid)IBA 11/01/1995 - "In this study of 15 patients with pure isolated constrictive pericarditis, we attempted to evaluate the diagnostic value of two non-invasive methods not usually employed in this indication: radionuclide angiography (RNA) and magnetic resonance imaging (MRI). " 11/01/1995 - "These results indicate that RNA and MRI are complementary non-invasive methods, and can provide the functional and anatomical information required for the diagnosis of constrictive pericarditis."
10.	Ethyl Ether (Ether)IBA 08/01/1957 - "Portal circulation in constrictive pericarditis; a study of the spleen-lung ether time in relation to splenoprotography before and after pericardiectomy."

Therapies and Procedures

1.	Pericardiectomy 06/10/1989 - "Early medical treatment with or without pericardiocentesis is effective in most cases of tamponade, but constrictive pericarditis demands pericardiectomy. " 06/01/1997 - "We concluded that pericardiectomy is a very effective treatment for constrictive pericarditis but a more careful follow up is required especially in cases complicated with other major problems because cardiac function is not so recovered as normal level after surgery due probably to readhesion and fibrotic changes of the myocardium." 09/01/1987 - "We conclude that pericardiectomy is an effective treatment of symptomatic chronic constrictive pericarditis because it provides an important and durable improvement in symptoms and functional Class, and it has a low operative mortality." 12/01/2007 - "Pericardiectomy is a useful procedure for constrictive pericarditis and was beneficial to all the patients in this study with an improvement in their functional capacity. " 12/01/1997 - "Pericardiectomy is the only effective surgical procedure for constrictive pericarditis, but we have often experienced a lack of significant improvement of hemodynamic parameters, this being attributed to the presence of residual constriction. "
2.	Transplants (Transplant) 08/01/2015 - "Constrictive pericarditis is a rare entity following lung transplant, with only seven previous cases reported in the literature. " 08/01/2015 - "Constrictive pericarditis post-lung transplant." 01/01/2015 - "He has excellent graft function, no recurrences or constrictive pericarditis after 2 years follow. " 01/01/2014 - "Constrictive pericarditis is a rare complication in the post-renal transplant period. " 01/01/2014 - "Constrictive pericarditis in a post-renal transplant patient: a case report."
3.	Electrodes (Electrode) 06/01/1996 - "Since removal of epicardial patches is an effective treatment of constriction, constrictive pericarditis should be systematically considered in patients with epicardial patch electrodes and impairment of functional status." 12/01/1996 - "Constrictive pericarditis can be associated with ICD patch electrodes. " 08/01/1987 - "The patient had complete resolution of signs and symptoms of constrictive pericarditis after removal of the patch electrodes and pericardial stripping. " 08/01/1987 - "Constrictive pericarditis from implanted patch electrodes appears to be an uncommon complication of the automatic implantable cardioverter-defibrillator and should be considered in patients with one or more patch electrodes and other signs of constrictive pericarditis." 08/01/1987 - "A case of constrictive pericarditis intimately involving patch electrodes of the automatic implantable cardioverter-defibrillator is described. "
4.	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 06/01/2001 - "Constrictive pericarditis (CP) is an unusual sequela of cardiac surgery, so the present study evaluated the clinical characteristics of patients with CP after coronary artery bypass grafting (CABG). " 03/01/2013 - "We report a patient who developed constrictive pericarditis after Coronary Artery Bypass Grafting. " 03/01/2013 - "Constrictive pericarditis following Coronary Artery Bypass Surgery is an uncommon disorder. " 03/01/2013 - "Constrictive pericarditis following coronary artery bypass grafting." 02/01/2013 - "Constrictive pericarditis after coronary artery bypass surgery has been known to affect cardiac output by limiting diastolic ventricular filling. "
5.	Thoracotomy 10/01/2005 - "Diagnosis of constrictive pericarditis is based on associated signs sometimes too poor to go straight to thoracotomy. " 12/01/2004 - "[A constrictive pericarditis on oral steroid and immunosuppressant treated with bilateral anterolateral thoracotomy; report of a case]." 12/01/2002 - "We conclude that the combined application of 3-dimensional CT, bilateral thoracotomy and doppler ultrasound blood flowmetry was a supreme strategy for the operation of constrictive pericarditis after CABG." 12/01/1983 - "Creation of a pericardial window through a left anterior thoracotomy was the procedure of choice in patients without signs of constrictive pericarditis or posterior loculated effusions and had excellent long-term results. " 11/01/2013 - "Sixty-four patients with constrictive pericarditis who were operated on with de novo radical pericardiectomy through a left anterolateral thoracotomy in our institute were entered into the study. "