Periapical Diseases

03/30/2017 - "The objective of this study was to observe the distribution of macrophages (MPs) expressing transforming growth factor beta-1 (TGF-β1) in tissue samples from patients with different human chronic periapical diseases. "
03/30/2017 - "Transforming growth factor beta-1 expression in macrophages of human chronic periapical diseases."
01/01/2017 - "Expression of transforming growth factor-β in mast cells in human chronic periapical diseases."
01/01/2017 - "This study was undertaken to investigate the distribution of mast cells (MCs) and the expression of transforming growth factor-β (TGF-β) on tryptase positive MCs in different types of human periapical diseases. "

04/01/2013 - "Further studies are necessary to elucidate the signaling pathways mediated by these cytokines and to facilitate the development of more effective periapical disease management strategies."
02/01/2002 - "Periapical exudate levels of both cytokines failed to reflect periapical disease state."
05/01/2022 - "Even though IL-6 is a key inflammatory cytokine in periapical lesions (PLs), its function in stable periapical disease is unknown. "
01/01/2019 - "However, a rise in immunosuppressive cytokines and chemokines (CCL4 and TGF-β) in periapical lesions suggests a role of these cytokines in stable periapical disease."
01/01/2019 - "Cytokines and chemokines associated with Treg/Th17 response in chronic inflammatory periapical disease."

12/01/2014 - "Bisphosphonate uptake in areas of tooth extraction or periapical disease."
06/16/2023 - "The study findings suggest that patients should undergo regular dental examinations to detect pulp and periapical disease before or during the administration of bisphosphonates and that root canal treatment should be considered to decrease the risk of osteonecrosis of the jaw."
06/16/2023 - "This longitudinal cohort study aimed to evaluate the relationship between osteonecrosis of the jaw and pulp and periapical disease in patients who were administered bisphosphonates. "
07/01/2013 - "Periapical disease and bisphosphonates induce osteonecrosis of the jaws in mice."
06/16/2023 - "Using data from a nationwide cohort, we examined the association among dental caries, pulp and periapical disease, and osteonecrosis of the jaw in women aged >50 years who received bisphosphonates for more than 1 year between 2002 and 2015. "

01/01/2019 - "This study aimed to assess the effect of zoledronic acid on an immunocompromised mice model with periapical disease. "
07/01/2013 - "Mice were injected with high dose zoledronic acid and pulpal exposure of mandibular molars was performed to induce periapical disease. "
12/01/2014 - "The authors tested the uptake of fluorescein-labeled zoledronic acid (5-FAM-ZOL) in sites of tooth extraction or experimental periapical disease in mice. "

09/01/2018 - "To explore the cytotoxicity of concentrate growth factors (CGF) and the effects on the apoptosis, proliferation and differentiation of human dental pulp cells (hDPCs), which were closely correlated with future application of CGF in the treatment of dental pulpal and periapical diseases. "
08/20/2021 - "In this article, we retrospectively examined the current treatment status and clinical goals of pulpal and periapical diseases and scrutinized biological studies of functional pulp regeneration with a focus on DPSCs, biomaterials, and growth factors. "

11/01/2005 - "The periapical exudate NE and PGE2 levels may regulate periapical disease expression, but the results of this study were unable to reveal this association."
12/01/1997 - "These results suggest the central roles of PGE2 in regulatory mechanisms for the expression of periapical disease."

06/01/2005 - "To investigate the effect of the treatment of periapical diseases with recombinant human netic protein (rhBMP-2) composite in dog models so as to provide basis for its clinical application. "
08/01/2010 - "Although this study was unable to demonstrate a significantly higher level of IL-1beta or DSP in the GCF of teeth with apical periodontitis, the observed presence of a significantly higher level of total protein in the GCF of diseased teeth suggests the possible role of total protein level as a marker for periapical disease."

03/01/2000 - "[Mechanisms of bone repairment in periapical diseases: studies on adjusting bone metabolism with calcium hydroxide in vitro]."
04/01/1973 - "IV. Effect of debridement procedures and calcium hydroxide-camphorated parachlorophenol paste in the treatment of experimentally induced pulp and periapical disease."

01/01/2016 - "The successful outcome achieved through VPT using CEM biomaterial in the reported case suggests that this method may produce favorable outcome for vital immature permanent teeth with irreversible pulpitis and periapical disease."
08/20/2021 - "In this article, we retrospectively examined the current treatment status and clinical goals of pulpal and periapical diseases and scrutinized biological studies of functional pulp regeneration with a focus on DPSCs, biomaterials, and growth factors. "

05/01/1991 - "Epithelial lining of sinus tracts associated with periapical disease: an immunocytochemical study using monoclonal antibodies to keratins."
03/01/1993 - "[Production of monoclonal antibody that recognize the common antigen of black-pigmented bacteroides and application in pulp and periapical diseases]."

06/01/2010 - "Root canal therapy is currently the most effective treatment for pulpal and periapical diseases. "
12/24/2022 - "Although it is very promising, the material of the files remains understudied, and further work is required to make material science a pervasive technology in root canal therapy, and contribute to endodontic and periapical diseases by assisting in the subsequent development of root canal files."
01/09/2022 - "Root canal therapy and endodontic surgery are conventional treatments for pulpal and periapical diseases. "
08/20/2021 - "Pulpal and periapical diseases account for a large proportion of dental visits, the current treatments for which are root canal therapy (RCT) and pulp revascularisation. "
01/01/2015 - "Root canal therapy is currently the main method to treat pulpal and periapical diseases. "

09/01/2017 - "Recent reviews confirm a general lack of randomized, controlled clinical studies on the efficacy of regenerative endodontics in immature teeth affected by pulp and periapical diseases. "
01/01/2020 - "Regenerative endodontic procedures (REPs) are a new option for the treatment of dental pulp or periapical diseases in permanent teeth with open apices. "

12/26/2022 - "Dental pulp and periapical diseases are common conditions in stomatology, caused by various pathogenic microorganisms. "
10/01/2016 - "In stomatology, root canal therapy is a commonly used and effective treatment for dental pulp diseases and periapical diseases. "

06/01/1983 - "The present study indicates that the large variation noted among clinical and radiographic studies on the results of endodontic therapy could partly be explained by difficulties in defining and maintaining criteria for radiological evidence of periapical disease."
05/01/2021 - "Our findings suggest that SPMs may play a role in the inception and treatment of pulpal-periapical diseases, and they should be considered for future research for developing new therapeutics as an adjunct to endodontic treatment."
01/01/2021 - "Root canal (RC) therapy is the primary treatment of dental-pulp and periapical diseases. "
09/01/2020 - "In our society, in which people will soon live beyond 100 years, this therapy should be efficacious for contributing to the functional survival and endurance of the tooth not only for pulpectomized young teeth but also for aged teeth with periapical disease. "
09/01/2015 - "Following a diagnosis of irreversible pulpal disease, periapical disease or failed endodontic therapy, the options for the tooth are extraction or root canal treatment. "

09/01/2013 - "One of the usual contraindications of the implant treatment is the presence of periapical disease associated to the tooth to be replaced. "
01/01/1988 - "[Surgical treatment of periapical disease of the tooth root; indications and contraindications]."
03/01/2006 - "Recent studies postulate that the proximity of the antral teeth to the maxillary sinus should not be viewed as a contraindication to periapical surgery, and recommend such surgery in teeth with chronic periapical disease that are refractory to conventional endodontic management, despite the proximity of the maxillary sinus."