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Perceptual Disorders (Hemispatial Neglect)

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Cognitive disorders characterized by an impaired ability to perceive the nature of objects or concepts through use of the sense organs. These include spatial neglect syndromes, where an individual does not attend to visual, auditory, or sensory stimuli presented from one side of the body.

Also Known As:

Hemispatial Neglect; Perceptual Disorder; Hemisensory Neglect; Sensory Neglect; Somatosensory Discrimination Disorder; Discrimination Disorder, Somatosensory; Discrimination Disorders, Somatosensory; Hemisensory Neglects; Hemispatial Neglects; Neglect, Hemisensory; Neglect, Hemispatial; Neglect, Sensory; Neglects, Hemisensory; Sensory Neglects; Somatosensory Discrimination Disorders

Networked: 66 relevant articles (6 outcomes, 11 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Stroke (Strokes)
2.	Parkinsonian Disorders (Parkinsonism)
3.	Hypokinesia (Bradykinesia)
4.	Schizophrenia (Dementia Praecox)
5.	Hemiplegia (Spastic Hemiplegia)

Experts

1.	Stein, Donald G: 3 articles (02/2014 - 11/2002)
2.	Hillis, Argye E: 2 articles (08/2010 - 05/2009)
3.	Harvey, Monika: 2 articles (01/2010 - 07/2007)
4.	Muir, Keith: 2 articles (01/2010 - 07/2007)
5.	Reeves, Ian: 2 articles (01/2010 - 07/2007)
6.	Kleinman, Jonathan T: 2 articles (05/2009 - 01/2008)
7.	Byun, Hee-Jung: 2 articles (03/2009 - 01/2008)
8.	Kim, Jong-Hoon: 2 articles (03/2009 - 01/2008)
9.	Hylin, Michael J: 1 article (10/2015)
10.	Brenneman, Miranda M: 1 article (10/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Perceptual Disorders:

1.	Progesterone FDA LinkGeneric 11/01/2002 - "With regard to behavioral outcome, only 5 days of progesterone injections resulted in improved spatial learning performance and reduced sensory neglect. " 08/01/2006 - "Vehicle (V)-treated rats were given 9 injections of 22.5% cyclodextrin, whereas AW rats received 9 injections of 16 mg/kg progesterone and TW rats received 7 injections of P at 16 mg/kg, followed by one at 8 mg/kg and one at 4 mg/kg. On day 8, sensory neglect and locomotor activity tests were initiated. " 02/01/2014 - "Both 8 and 16 mg/kg doses of progesterone produced attenuation of infarct volume compared with the placebo, and improved functional outcomes up to 3 weeks after stroke on locomotor activity, grip strength, sensory neglect, gait impairment, motor coordination and spatial navigation tests. "
2.	Oxidopamine (6 Hydroxydopamine)IBA 03/01/1984 - "The unilateral injection of 6-hydroxydopamine (8 micrograms) into the ventral tegmental area of awake rats produced a rapidly developing and irreversible sensory neglect to contralateral tactile stimuli. " 05/05/1979 - "The degree of the contralateral sensory neglect in rats with unilateral 6-OHDA lesions of substantia nigra was assessed by a conditioning procedure, employing lateralized CS. " 05/01/1998 - "Similarly, rats that were subjected to corticostriatal deafferentation (confirmed by sensory neglect tests) and 6-OHDA lesion (1 week or 3 weeks later) showed no significant reduction in the striatal Fos hyperexpression induced by amphetamine (0.5 mg/kg or 5 mg/kg) and no significant rotational asymmetry. " 01/01/1981 - "These data indicate that 6-OHDA lesions of substantia nigra and ventral midbrain areas do not produce sensory neglect simply by increasing GABA transmission within the nigrotectal pathway. " 01/01/1981 - "Collicular picrotoxin alleviates akinesia but not sensory neglect in rats with bilateral 6-hydroxydopamine lesions of ventral midbrain."
3.	Amphetamine (Amfetamine)FDA LinkGeneric 10/15/2015 - "The time-dependent and persistent effects of amphetamine treatment upon recovery from hemispatial neglect in rats." 05/01/1998 - "Similarly, rats that were subjected to corticostriatal deafferentation (confirmed by sensory neglect tests) and 6-OHDA lesion (1 week or 3 weeks later) showed no significant reduction in the striatal Fos hyperexpression induced by amphetamine (0.5 mg/kg or 5 mg/kg) and no significant rotational asymmetry. " 10/20/1980 - "The motor asymmetry, and the contralateral 'sensory neglect' induced by a unilateral destruction of the nigrostriatal DA pathway, were monitored in the transplanted rats and in non-transplanted controls through repeated measurements of the amphetamine-and apomorphine-induced rotational behaviour, and through analysis of the rats performance in a number of sensorimotor tests. "
4.	Tacrolimus (Prograf)FDA LinkGeneric 02/01/2001 - "Skilled use of the forelimb ipsilateral to the ICH was improved and sensory neglect of the same limb was decreased 8-9 weeks post-ICH in rats treated with FK-506. "
5.	Dopamine (Intropin)FDA LinkGeneric 08/01/1985 - "Extensive damage to central dopamine (DA)-containing neurons are known to produce akinesia and sensory neglect when the lesions are made in adult rats. " 01/01/1981 - "Moreover, it has been proposed that this increase in inhibitory activity within the colliculus may be responsible for the sensory neglect commonly observed after dopamine denervation. " 07/07/1987 - "Dopamine-rich grafts ameliorate whole body motor asymmetry and sensory neglect but not independent limb use in rats with 6-hydroxydopamine lesions." 03/01/1984 - "The extent of sensory neglect and changes in dopamine metabolism in the neostriatum varied according to the amount of gamma-hydroxybutyric acid injected into the nigra and according to the proximity of injections of gamma-hydroxybutyric acid to the pars compacta. " 07/01/2007 - "The resemblance of some aspects of the hemispatial neglect syndrome (hypokinesia, decreased arousal) to aspects of Parkinsonian syndromes, and the success of amantadine in treating disorders of attention, prompted a placebo-controlled, double-blind trial of amantadine, an inhibitor of the N-methyl D-aspartate (NMDA) glutamate receptor that modulates dopamine transmission, in four patients with chronic hemispatial neglect. "
6.	Carbon MonoxideIBA 07/01/2007 - "Spatially lateralised deficits that typically define the hemispatial neglect syndrome have been shown to co-occur with other non-lateralised deficits of attention, memory, and drawing. " 10/01/2003 - "In accordance with the previous studies, we found no relationship between the degree of awareness of field defect and anatomic lesions, co-existence of hemispatial neglect, or the degree of awareness of hemiplegia. " 06/01/1988 - "The weak co-occurrence of optic ataxia and hemispatial neglect, and their different lesion sites, indicate a double dissociation between these two symptoms."
7.	Glutamate Receptors (Glutamate Receptor)IBA 07/01/2007 - "The resemblance of some aspects of the hemispatial neglect syndrome (hypokinesia, decreased arousal) to aspects of Parkinsonian syndromes, and the success of amantadine in treating disorders of attention, prompted a placebo-controlled, double-blind trial of amantadine, an inhibitor of the N-methyl D-aspartate (NMDA) glutamate receptor that modulates dopamine transmission, in four patients with chronic hemispatial neglect. "
8.	N-Methylaspartate (NMDA)IBA 07/01/2007 - "The resemblance of some aspects of the hemispatial neglect syndrome (hypokinesia, decreased arousal) to aspects of Parkinsonian syndromes, and the success of amantadine in treating disorders of attention, prompted a placebo-controlled, double-blind trial of amantadine, an inhibitor of the N-methyl D-aspartate (NMDA) glutamate receptor that modulates dopamine transmission, in four patients with chronic hemispatial neglect. "
9.	Hemoglobins (Hemoglobin)IBA 08/01/2010 - "The purpose of this study was to determine in acute stroke patients whether lower hemoglobin values were associated with worse hemispatial neglect. "
10.	Atropine (Hyoscyamine)FDA LinkGeneric 09/01/1969 - "1. A field trial was conducted in order to assess the effect upon tasks, including hard labour, skilled work, the use of instruments and tools and shooting, of giving 6 mg of atropine sulphate by injection to twenty-three adult male volunteers.2. Impairment of performance was seen in these tasks under the influence of the drug, but this was statistically significant only in some of them.3. Drowsiness occurred in twenty-one men and perceptual disorders were common, but two men were almost completely resistant to the effects of the drug.4. The implications of the therapeutic use of comparable doses of atropine are discussed."

Therapies and Procedures

1.	Activities of Daily Living (ADL) 01/01/2010 - "Prism intervention helped sustainability of effects and ADL performances in chronic hemispatial neglect: a follow-up study." 03/01/2011 - "We compared visual scanning and mental practice and explored the effects of these techniques on specific hemispatial neglect tests and activities of daily living in chronic hemispatial neglect patients. " 01/01/2010 - "Long term improvements in activities of daily living in patients with hemispatial neglect." 01/01/2010 - "The results suggested that long-term prism intervention might effectively exert long-lasting effects and bring benefits to ADL performance for subjects with hemispatial neglect." 01/01/2010 - "To investigate the sustainability of effect and the changes in basic and instrumental activities of daily living (ADL and IADL) after long-term prism intervention, we carried out a follow-up assessment on five subjects with hemispatial neglect in the chronic stage. "
2.	Injections 11/01/2002 - "With regard to behavioral outcome, only 5 days of progesterone injections resulted in improved spatial learning performance and reduced sensory neglect. " 08/01/2006 - "Vehicle (V)-treated rats were given 9 injections of 22.5% cyclodextrin, whereas AW rats received 9 injections of 16 mg/kg progesterone and TW rats received 7 injections of P at 16 mg/kg, followed by one at 8 mg/kg and one at 4 mg/kg. On day 8, sensory neglect and locomotor activity tests were initiated. " 03/01/1984 - "The extent of sensory neglect and changes in dopamine metabolism in the neostriatum varied according to the amount of gamma-hydroxybutyric acid injected into the nigra and according to the proximity of injections of gamma-hydroxybutyric acid to the pars compacta. "
3.	Self-Help Devices (Assistive Technology) 01/01/2003 - "Findings also suggest that more research is needed into how the assessment of specific features of visual perceptual disorders might lead to improved methods for rehabilitation, including the use of assistive devices for mobility and activities of daily living."
4.	Aftercare (After-Treatment) 01/03/2012 - "This study provides Class III evidence that left posterior parietal cortex theta-burst stimulation improves hemispatial neglect for up to 2 weeks after treatment." 01/01/2008 - "After treatment of his seizures, his Capgras syndrome and hemispatial neglect resolved. " 10/07/2002 - "Three months after treatment, rats exhibited exaggerated rotational behavior induced by L-dihydroxyphenylalanine (L-DOPA) and contralateral sensory neglect. "
5.	Hemispherectomy 05/01/2009 - "The objective of this study was to determine the incidence and types of hemispatial neglect in children and young adults following both right- and left-sided hemispherectomy; which types of spatial attention functions can be assumed by the opposite hemisphere; and whether factors like their age at time of surgery, handedness, or gender influence recovery. " 05/01/2009 - "Thirty-two children and young adults who had previously undergone hemispherectomy were administered two tests to evaluate for two types of hemispatial neglect: a gap detection test and a line cancellation test. " 05/01/2009 - "Hemispherectomy sustained before adulthood does not cause persistent hemispatial neglect." 04/01/2013 - "The patient underwent right hemispherectomy for treatment of refractory epilepsy and did not have hemispatial neglect after surgery, supporting transfer of function prior to the operation. "