Peptidyl Transferases (Peptidyltransferase)

Acyltransferases that use AMINO ACYL TRNA as the amino acid donor in formation of a peptide bond. There are ribosomal and non-ribosomal peptidyltransferases.

Also Known As:

Peptidyltransferase; Peptidyltransferases; Transferase, Peptidyl; Transferases, Peptidyl; Translocase, Peptidyl; Translocases, Peptidyl; Peptidyl Transferase; Peptidyl Translocase; Peptidyl Translocases; Transpeptidase; Transpeptidases; Peptidyl-tRNA:aminoacyl-tRNA N-peptidyltransferase

Networked: 141 relevant articles (0 outcomes, 11 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Acyltransferases: 374
      - Aminoacyltransferases
        Peptidyl Transferases: 141
        E coli YcbB protein
        Streptococcus pneumoniae PBP1a protein

Experts

1.	Arthur, Michel: 7 articles (02/2021 - 06/2008)
2.	Hugonnet, Jean-Emmanuel: 5 articles (01/2020 - 10/2007)
3.	Lamichhane, Gyanu: 4 articles (12/2018 - 04/2010)
4.	Edoo, Zainab: 3 articles (02/2021 - 12/2019)
5.	Dubée, Vincent: 3 articles (12/2019 - 08/2012)
6.	Mainardi, Jean-Luc: 3 articles (08/2012 - 06/2008)
7.	Etheve-Quelquejeu, Mélanie: 2 articles (02/2021 - 12/2019)
8.	Brem, Jürgen: 2 articles (01/2020 - 08/2019)
9.	Langley, Gareth W: 2 articles (01/2020 - 08/2019)
10.	Lohans, Christopher T: 2 articles (01/2020 - 08/2019)

Related Diseases

1.	Tuberculosis (Tuberculoses) 01/01/2020 - "Mycobacterium tuberculosis l,d-transpeptidases (Ldts), which are involved in cell-wall biosynthesis, have emerged as promising targets for the treatment of tuberculosis. " 12/01/2018 - "tuberculosis is catalyzed by l,d-transpeptidases. " 10/16/2015 - "tuberculosis PG is predominantly 3→3 cross-linked, and LdtMt2 is the dominant ld-transpeptidase. " 01/01/2010 - "tuberculosis transpeptidases." 01/01/2016 - "tuberculosis is an important human pathogen, these structural data provide a template to design novel transpeptidase inhibitors to treat tuberculosis infections. "
2.	Neoplasms (Cancer) 10/01/2017 - "Study to assess Activity and Concentration of Gammaglutamyl Transpeptidase in Precancerous and Cancer Patients and Its Comparison with Controls." 01/01/1978 - "Tumor ribosomes showed an increased activity of both the acceptor and donor binding site of peptidyl transferase. " 01/28/1978 - "[Assay of gamma glutamyl transpeptidases (gamma GT) for the diagnosis of hepatic metastases of bronchopulmonary cancers]." 12/23/2020 - "The new compounds exhibited moderate inhibition against transpeptidase sortase A and weak inhibition against human pathogenic bacteria and A549 and K562 cancer cell lines." 03/01/2005 - "It is more common to discover focal liver pathology in patients with non-hepatic tumors and less probable when phosphatase alcaline: gamma-glutamil transpeptidase ratio is higher than two."
3.	Fibrosis (Cirrhosis) 09/01/2014 - "During multivariate analysis genotypes 2/3 were significantly associated with higher sustained virological response rates; cirrhosis and γ-glutamil-transpeptidase >2 times the normal limit were associated with poorer response. " 08/01/1997 - "No significant differences were found between patients with and without cirrhosis except in some laboratory findings (leukocytes, platelets, erythrocyte sedimentation rate and gammaglutamyl transpeptidase higher in the latter group, and alpha-fetoprotein higher in the former). " 08/27/2018 - "BMI, WC, γ-glutamil transpeptidase, CK-18 and fibrosis index are significantly higher in group II patients with SH compared with group I, there is no significant difference in the level of cytolysis, inflammation and dyslipidemia indices. " 01/01/2020 - "Multivariable analysis revealed that age (P <0.001), pentraxin 3 (PTX3) levels (P = 0.009), γ‑glutamyl transpeptidase (GGT) to platelet count (PLT) ratio (P = 0.08), and hyaluronic acid levels (HA) (P = 0.07) were independent predictors of significant fibrosis. " 02/05/1996 - "Patient demographic and epidemiologic characteristics, pretreatment serum alanine aminotransferase (ALT) and 2-gamma-glutamyl transpeptidase (GGT) levels, histological grading of hepatic steatosis, necroinflammatory activity and fibrosis, serum hepatitis C virus (HCV) RNA titres and genotype and post-treatment serum ALT levels and presence of HCV RNA. "
4.	Hepatocellular Carcinoma (Hepatoma) 08/25/1987 - "A human hepatoma-derived cell line, Hep G2, expresses relatively high transpeptidase activity. " 05/01/1984 - "Comparative study by using hydrazinolysis has revealed that the carbohydrate moieties of gamma-glutamyl transpeptidases purified from rat liver and rat AH-66 hepatoma are quite different. " 04/01/1980 - "The sera of 122 patients with biopsy confirmed primary hepatocellular carcinoma (PHC) were examined for the presence of alphafoetoprotein (AFP), alpha 1antitrypsin 1 (AAT), alpha 1acidglycoprotein (AGP) 1, gammaglutamyl transpeptidase (GGT), carcinoemryonic antigen (Roche) (CEA) and the "Hepatoma-Liver antigen" H-L Ag). " 10/13/1981 - "In contrast to the complete abolition of transpeptidase activity of the purified hepatoma enzyme by diazotized sulphanilic acid, the hydrolytic activity of this preparation was only slightly inhibited." 10/21/2023 - "This study aimed to analyze the relationship between serum gamma-glutamate-transpeptidase to platelet ratio, alkaline phosphatase-to-platelet ratio index, fibrosis index based on four factors and the risk of hepatocellular carcinoma, and to determine the optimal cut-offs for predicting hepatocellular carcinoma. "
5.	Starvation 01/01/2023 - "baumannii and therefore block the transpeptidase function of the RodA-PBP2 system, the molecular details underpinning cell wall elongation inhibition upon Zn starvation remain undefined. " 06/01/2008 - "A candidate gene, previously shown to be upregulated upon nutrient starvation, was found to encode an L,D-transpeptidase active in the formation of 3-->3 cross-links. " 06/01/1998 - "The activity of ribosomes from a clinical isolate of Escherichia coli, exposed to starvation for 7 days in sea salts medium, was investigated by measuring the kinetic parameters of ribosomal peptidyltransferase, by using the puromycin reaction as a model reaction. " 01/01/2017 - "Our study demonstrates that chloramphenicol and blasticidin S that target the peptidyl transferase centre of the bacterial ribosome can then inhibit dissociation of 70S ribosome mediated by (i) unfolded protein, (ii) translation factors or (iii) low Mg+2 concentrations in vitro and thereby suppresses ribosomal degradation during carbon starvation in vivo. " 06/01/1998 - "(kmax is the apparent catalytic rate constant of peptidyl transferase, and Ks is the dissociation constant of the encounter complex between acetyl (Ac)[3H]Phe-tRNA-poly(U)-ribosome and puromycin.) Although the distribution of ribosomal particles remained constant, a substantial decrease in the number of ribosomes per starved cell and a clear decline in the ability of ribosomes to bind AcPhe-tRNA were observed, particularly during the first day of starvation. "

Related Drugs and Biologics

1.	Alkaline Phosphatase
2.	Aspartate Aminotransferases (Aspartate Transaminase)
3.	Enzymes
4.	gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)
5.	Glutamic Acid (Glutamate)
6.	Proteins (Proteins, Gene)
7.	Isoenzymes
8.	beta-Lactamase Inhibitors
9.	Vitamin D
10.	Rifampin (Rifampicin)

Related Therapies and Procedures

1.	Ambulatory Care (Outpatient Care)
2.	Oral Administration
3.	Therapeutics
4.	Aftercare (After-Treatment)