Peptic Ulcer (Peptic Ulcers)

Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).

Also Known As:

Networked: 11271 relevant articles (633 outcomes, 1084 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hemorrhage
2.	Ulcer
3.	Infections
4.	Dyspepsia (Indigestion)
5.	Gastroesophageal Reflux (GERD)

Experts

1.	Lanas, Angel: 32 articles (10/2021 - 09/2002)
2.	Lin, Hwai-Jeng: 23 articles (01/2017 - 04/2002)
3.	Sung, Joseph J Y: 21 articles (01/2022 - 02/2003)
4.	Malfertheiner, P: 17 articles (01/2018 - 08/2000)
5.	Chan, Francis K L: 16 articles (01/2020 - 09/2002)
6.	Shiotani, Akiko: 16 articles (07/2015 - 01/2002)
7.	Howden, Colin W: 15 articles (01/2021 - 02/2002)
8.	Kim, Nayoung: 15 articles (09/2019 - 09/2003)
9.	Haruma, Ken: 15 articles (07/2015 - 02/2002)
10.	Gisbert, J P: 15 articles (10/2011 - 01/2001)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Peptic Ulcer:

1.	Proton Pump InhibitorsIBA 08/23/2017 - "Regarded as safe and effective for management of upper peptic ulcer disease due to gastric acid secretion, the proton pump inhibitors are among the most commonly prescribed drugs. " 01/01/1992 - "These results suggest that proton pump inhibitors are highly effective in the treatment of peptic ulcer resistant to H2-receptor antagonists." 04/01/1998 - "Proton pump inhibitors have been found to be effective in numerous studies in patients with peptic ulcer disease, particularly associated with Helicobacter pylori and gastro-oesophogeal reflux disorders. " 11/01/2010 - "Proton pump inhibitor (PPI) is an effective and safe medication for the elderly people for the treatment of peptic ulcer disease. " 05/21/2010 - "The proton pump inhibitors (PPIs) as a class are remarkably safe and effective for persons with peptic ulcer disorders. "
2.	Omeprazole (Prilosec)FDA LinkGeneric 06/01/1990 - "It is concluded that omeprazole is highly effective in healing refractory peptic ulcers." 06/01/2018 - "Previous studies performed in adult patients have demonstrated that both scheduled second look endoscopy and high dose continuous omeprazole infusion are effective in the prevention of peptic ulcer rebleeding. " 08/01/2016 - "Previous studies have shown that both scheduled second-look endoscopy and high-dose continuous omeprazole infusion are effective in preventing peptic ulcer rebleeding. " 08/01/1988 - "From these results, omeprazole can be expected to be useful for the treatment of peptic ulcer disease." 04/09/2021 - "This study compares the efficacy of oral omeprazole vs intravenous omeprazole in decrease of rebleeding of peptic ulcer patients. "
3.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 08/01/2005 - "The persisting high incidence of peptic ulcer disease is a superimposing of two trends: a higher incidence in the growing population of elderly patient with a higher intake of NSAIDs and a lower incidence among younger patients due to a decrease in incidence and improved medical treatment." 10/01/2012 - "Although the risk factors for the development of marginal ulcer remain multifactorial, a thorough investigation for potential etiologies including tobacco, alcohol, and nonsteroidal antiinflammatory drug (NSAID) usage should be determined and eliminated. " 01/01/2006 - "pylori should be eradicated from symptomatic Middle Eastern NSAID users with peptic ulcer disease." 10/04/1997 - "We studied the efficacy of eradication of H pylori in the prevention of NSAID-induced peptic ulcers. " 10/31/2023 - "Register-based self-controlled case series study including adults ≥65 years with a new prescription of ChEIs and NSAIDs, diagnosed with incident peptic ulcer in Sweden, 2007-2020. "
4.	AcidsIBA 04/01/1986 - "Most peptic ulcers relapse after modern acid reducing treatment, and antibacterial treatment may be beneficial in preventing relapse." 01/01/2003 - "Acid suppression is effective in preventing rebleeding from peptic ulcer. " 01/01/2016 - "Peptic ulcer, which is mainly caused by bacterial attack or excess of acid secretion, can be cured effectively by these isolated plant compounds. " 03/15/2006 - "Following the improved understanding of gastric secretory physiology, and the development of acid suppressants with increasing efficacy, the use of surgical intervention for peptic ulcer disease was almost eliminated. " 07/01/1978 - "Further evaluation may prove it to be helpful in the clinical treatment of acid hypersecretory states and peptic ulcer disease."
5.	Cimetidine (Biomet)FDA LinkGeneric 04/01/1994 - "We conclude that twice-daily cimetidine at a dosage of 20 mg/kg/day is as effective for the symptomatic improvement and healing of peptic ulcer as the conventional three- or four-times-daily regimens. " 10/01/1988 - "It is concluded that long-term use of cimetidine is effective in the management of peptic ulcer disease, and continuous treatment for up to 6 years has not revealed any previously unknown hazard." 06/01/1986 - "Both are endocrinopathies that require doses of cimetidine in excess of that normally considered therapeutic for peptic ulcer disease. " 02/01/1978 - "Cimetidine: a review of its pharmacological properties and therapeutic efficacy in peptic ulcer disease." 10/01/1983 - "An open study was conducted to assess the efficacy of Cimetidine one gram daily in the treatment of peptic ulcer amongst outpatients in Singapore. "
6.	Ranitidine (Zantac)FDA LinkGeneric 09/01/1985 - "Ranitidine 300 mg hs appears to be equally safe and effective as the standard regimen of 150 mg bid in the short-term treatment of uncomplicated gastroduodenal ulcer." 06/01/1984 - "Ranitidine--new relief for peptic ulcers." 06/01/1987 - "Fifteen patients with peptic ulcer underwent 24 hour studies of gastric contents: before and on completing six weeks' treatment with oral ranitidine 150 mg bd, twice on maintenance treatment for nine to 12 months and one month after stopping the drug. " 11/01/1985 - "[3-year trial of preventing recurrence of peptic ulcer with ranitidine]." 04/01/1984 - "[Open study of ranitidine in short-term treatment of gastroduodenal ulcer]."
7.	Epinephrine (Adrenaline)FDA LinkGeneric 01/01/2003 - "For peptic ulcer, injection of larger volumes of epinephrine (adrenaline; mean 16.5 ml) are more effective than small volumes (mean 8 ml). " 10/18/1997 - "Adding heat probe treatment to adrenaline injection for spurting haemorrhage of peptic ulcers. " 01/01/1991 - "Endoscopic injection of adrenaline for severe peptic ulcer haemorrhage in high surgical risk patients." 01/01/1969 - "[Adrenaline loading test in peptic ulcer]." 02/01/1995 - "A prospective randomized trial was performed to assess the efficacy of the combined therapy of endoscopic injection of adrenaline and heater probe application in the management of patients with major peptic ulcer haemorrhage. "
8.	Sucralfate (Carafate)FDA LinkGeneric 06/01/1985 - "Sucralfate is an effective medication in preventing the recurrence of peptic ulcer. " 01/01/1981 - "Its therapeutic efficacy, combined with the fact that it is well tolerated and free of serious systemic effects, enhances sucralfate's therapeutic clinical usefulness in the treatment of peptic ulcer disease." 01/01/1987 - "International studies have shown sucralfate to be a safe and effective short- and long-term treatment for patients with peptic ulcer. " 01/01/1989 - "[A comparative evaluation of the efficacy of sucralfate and H2-histamine blockaders in treating peptic ulcer]." 08/29/1988 - "[Multicenter clinical studies of the effectiveness of sucralfate in the treatment of peptic ulcer]."
9.	AntacidsIBA 01/01/1999 - "The efficacy of antacids in the short- and long-term treatment of peptic ulcers, has suggested a possible use in the prevention and in the treatment of non-steroidal anti-inflammatory drug related gastroduodenal lesions. " 01/01/1991 - "Efficacy of low-dose antacids in the treatment of peptic ulcers: pharmacological explanation?" 05/14/1954 - "[Intragastric pH measurement of determination of efficacy of antacids in peptic ulcer]." 08/01/1991 - "There have been a number of controlled trials of antacids in the treatment of patients with peptic ulcer disease. " 05/31/1970 - "[Clinical and radiographical study on the effects of the treatment of peptic ulcer with a new antacid-antiulcer agent]."
10.	Famotidine (Pepcid)FDA LinkGeneric 10/01/1994 - "Twice daily administration of 0.5 mg/kg famotidine for 8 weeks appears to be a tolerated and effective treatment of children with gastroduodenal ulcers." 07/01/2009 - "The study aim was to evaluate the efficacy of famotidine in Japanese patients with peptic ulcers; it was analyzed the pooled data from previously conducted clinical trials in Japan. " 08/01/1996 - "In that study, the maximal dosage of famotidine was limited to 40 mg/day, the recommended maximal dosage for the treatment of peptic ulcer disease. " 01/01/1993 - "Our study shows that the pharmacokinetics of famotidine in patients with reflux oesophagitis is comparable to that in healthy volunteers and peptic ulcer patients. " 01/05/2022 - "Famotidine (FMD) is a highly potent H2-receptor antagonist used in peptic ulcer treatment. "

Therapies and Procedures

1.	Therapeutics 01/01/2004 - "During the past 20 years medical therapy of peptic ulcer disease (PUD) has dramatically improved. " 04/01/2002 - "Medical therapy of peptic ulcer disease (PUD) has improved dramatically during the past 20 years with the introduction of modern antisecretory drugs as well as eradication therapy of Helicobacter pylori. " 01/01/1996 - "Effective and well-tolerated eradication therapies are now available, and represent the most cost-effective treatment for peptic ulcer disease." 04/01/1983 - "Therapy for 4 or 8 wk is highly effective in the treatment of uncomplicated gastroduodenal ulcer." 01/01/2007 - "pylori eradication in peptic ulcer disease is very effective with systematic reviews giving a number needed to treat of around two compared to no therapy. "
2.	Endoscopic Hemostasis 05/01/2003 - "Endoscopic hemostasis: safe treatment for peptic ulcer patients aged 80 years or older?" 01/01/2018 - "This study aimed to investigate the effectiveness of scheduled second-look endoscopy (EGD) with endoscopic hemostasis on peptic ulcer rebleeding and to identify the risk factors related to the need for second-look EGD. " 09/01/2012 - "In this study, the aim was to determine the demographic characteristics of elderly patients with gastroduodenal ulcer who had undergone endoscopic hemostasis by comparing them with younger patients. " 12/09/2022 - "Although endoscopic hemostasis for UGIB due to peptic ulcer had a favorable outcome, old age and severe comorbidities were risk factors for poor prognosis. " 02/14/2022 - "Peptic ulcer rebleeding often occurs within three days after emergent endoscopic hemostasis. "
3.	Electrocoagulation (Electrocautery) 07/01/1990 - "We conducted a prospective randomised controlled trial of 137 patients with massive peptic ulcer haemorrhage over a period of 12 months to compare the haemostatic effects of endoscopic heat probe thermocoagulation and pure alcohol injection. " 07/01/1990 - "Heat probe thermocoagulation and pure alcohol injection in massive peptic ulcer haemorrhage: a prospective, randomised controlled trial." 11/01/1985 - "The aim of this study was to evaluate the efficacy and the safety of liquid monopolar electrocoagulation in the endoscopic control of major haemorrhage from peptic ulcers. " 08/26/2011 - "Heater probe thermocoagulation for high-risk patients who show rebleeding from peptic ulcers." 07/01/1990 - "We suggest that heat probe thermocoagulation should be the first treatment of choice for arrest of massive peptic ulcer haemorrhage."
4.	Vagotomy 11/01/1977 - "In the treatment of peptic gastroduodenal ulcers the modified vagomotor electrotest according to Burge has yielded remarkably good results as an intraoperative test for the completeness of proximal selective vagotomy (PSV). " 01/01/1975 - "It would appear that vagotomy with double pyloroplasty is a safe and effective operation for peptic ulcers and that further clinical trials are warranted." 03/01/1988 - "Early postoperative studies of stimulated gastric acid secretion have led to improved surgical performance during trials of operations using vagotomy for control of peptic ulcer disease. " 03/01/1991 - "The authors generalize the material on the surgical treatment of 151 patients who were operated on for complicated gastroduodenal ulcers by means of an improved method of tubular resection of the stomach with selective vagotomy, subtotal excision of the lesser curvature, and the formation of a ++post-colonic rectangular gastroenteroanastomosis on a short loop with oblique division of the jejunum. " 12/01/1989 - "The results obtained in this study show that oxyntic cell vagotomy with simple closure of the perforation may be the technique of choice in the treatment of perforated duodenal peptic ulcer, which is why we think is should be more extensively used in emergency services."
5.	Light Coagulation 05/17/1986 - "The efficacy of Nd-YAG laser photocoagulation in the endoscopic control of haemorrhage from peptic ulcers was shown in a controlled trial. " 01/01/1985 - "58 patients were found to have peptic ulcers, of which 42 had stigmata of recent haemorrhage accessible to laser photocoagulation. " 06/01/1987 - "A randomized trial comparing the efficacy of BICAP electrocoagulation and YAG laser photocoagulation was carried out in 100 patients presenting at endoscopy with peptic ulcer and a spurting or oozing vessel or a nonbleeding vessel. " 05/17/1986 - "Controlled trial of Nd-YAG laser photocoagulation in bleeding peptic ulcers." 06/25/1987 - "We conclude that Nd:YAG-laser photocoagulation does not benefit patients with acute upper gastrointestinal bleeding from peptic ulcers."