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Pentosan Sulfuric Polyester (Pentosan Polysulfate)

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A sulfated pentosyl polysaccharide with heparin-like properties.

Also Known As:

Pentosan Polysulfate; Elmiron; SP 54; Pentosan Polysulfate Sodium; PZ 68; BAY-946; Fibrocid; HOE-946; HOE-BAY 946; HOE-BAY-946; Hemoclar; PZ-68; PZ68; Pentosan Polysulphate Sodium; Pentosane Sulfuric Polyester; Polysulfated Xylan; SP-54; Tavan SP 54; Xylan SP54; Xylan Sulfate; 54, Tavan SP; 946, HOE-BAY; BAY 946; HOE 946; HOE BAY 946; Polyester, Pentosan Sulfuric; Polyester, Pentosane Sulfuric; Polysulfate Sodium, Pentosan; Polysulfate, Pentosan; Polysulphate Sodium, Pentosan; SP 54, Tavan; SP54; SP54, Xylan; Sodium, Pentosan Polysulfate; Sodium, Pentosan Polysulphate; Sulfate, Polypentose; Sulfate, Xylan; Sulfuric Polyester, Pentosan; Sulfuric Polyester, Pentosane; Xylan, Polysulfated; Polypentose Sulfate; Xylan, hydrogen sulfate

Networked: 196 relevant articles (18 outcomes, 34 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Nickel, J Curtis: 8 articles (03/2015 - 03/2002)
2.	Parsons, C Lowell: 4 articles (06/2009 - 03/2002)
3.	Kumagai, Kenji: 3 articles (06/2014 - 01/2010)
4.	Niwa, Masami: 3 articles (06/2014 - 01/2010)
5.	Vlassara, Helen: 3 articles (01/2013 - 10/2011)
6.	Caughey, Byron: 3 articles (04/2012 - 01/2006)
7.	Kocisko, David A: 3 articles (04/2012 - 01/2006)
8.	Ghosh, Peter: 3 articles (01/2010 - 02/2003)
9.	Forrest, John: 3 articles (06/2009 - 03/2002)
10.	Wan, George J: 3 articles (06/2009 - 01/2008)

Related Diseases

1.	Interstitial Cystitis (Interstitial Cystitis, Chronic) 12/01/2008 - "Re: Safety and efficacy of the use of intravesical and oral pentosan polysulfate sodium for interstitial cystitis: a randomized double-blind clinical trial: E. " 07/01/2008 - "Re: Safety and efficacy of the use of intravesical and oral pentosan polysulfate sodium for interstitial cystitis: a randomized double-blind clinical trial. " 01/01/2008 - "We examined the safety and the efficacy of a combination of intravesical and oral pentosan polysulfate sodium in comparison to only oral pentosan polysulfate sodium in treating interstitial cystitis. " 01/01/2008 - "Safety and efficacy of the use of intravesical and oral pentosan polysulfate sodium for interstitial cystitis: a randomized double-blind clinical trial." 07/01/1997 - "Efficacy of pentosan polysulfate in the treatment of interstitial cystitis: a meta-analysis."
2.	Osteoarthritis 12/01/2014 - "Survey of the therapeutic approach and efficacy of pentosan polysulfate for the prevention and treatment of equine osteoarthritis in veterinary practice in Australia." 12/01/2014 - "To survey veterinary practitioners in Australia on how they administer pentosan polysulfate (PPS) to horses and their perceptions of the efficacy of PPS for: the prevention and treatment of osteoarthritis (OA), the treatment of OA when PPS is combined with other drugs, and the efficacy of PPS compared with other disease-modifying osteoarthritic drugs. " 03/01/1996 - "Pentosan polysulfate (PPS) has been shown to improve symptoms of patients with osteoarthritis (OA) when studied under double-blinded conditions. " 01/01/2010 - "This study was undertaken to determine whether the anti-osteoarthritis drug pentosan polysulfate (PPS) influenced mesenchymal precursor cell (MPC) proliferation and differentiation. " 05/01/2012 - "To assess clinical, radiographic, histologic, and biochemical effects of sodium pentosan polysulfate (NaPPS) administered IM for treatment of experimentally induced osteoarthritis in horses. "
3.	Pelvic Pain 10/01/2004 - "For patients treated with pentosan polysulfate or cystoscopic hydrodistention, or both, plus diet changes (n=78), Pelvic Pain and Urgency/Frequency scores improved 34.2%, from 15.01 to 9.87. " 04/01/2005 - "Pentosan polysulfate sodium therapy for men with chronic pelvic pain syndrome: a multicenter, randomized, placebo controlled study." 04/01/2005 - "We evaluated the efficacy and tolerability of pentosan polysulfate sodium (PPS) for the treatment of men with chronic pelvic pain syndrome (CPPS), National Institutes of Health (NIH) category III. In a 16-week double-blind study 100 men with a clinical diagnosis of CPPS were randomized to receive 300 mg PPS or placebo 3 times daily. " 09/01/2000 - "Pentosan polysulfate sodium (PPS), an oral medication indicated for the treatment of interstitial cystitis, has shown moderate benefit in reducing chronic pelvic pain and voiding symptoms in patients with interstitial cystitis. " 09/01/2000 - "Pentosan polysulfate therapy for chronic nonbacterial prostatitis (chronic pelvic pain syndrome category IIIA): a prospective multicenter clinical trial."
4.	Urinary Calculi (Urinary Calculus) 07/01/1998 - "Sodium pentosan polysulphate administration brought about a significant reduction in urinary stone forming constituents. " 02/01/1991 - "[Studies of sodium pentosan polysulphate (SPP) therapy on the urinary stone disease. " 01/01/1996 - "Effect of sodium pentosan polysulfate and citrate on urinary stone formation in hyperoxaluric rats."
5.	Cystitis 10/01/2004 - "The management of haemorrhagic cystitis with sodium pentosan polysulphate." 01/01/1994 - "With the intent of preventing bacterial adsorption, treatment of bacterial cystitis by intravesical instillation of pentosan polysulfate (PPS) was evaluated. " 02/01/2012 - "Introduction of sodium pentosan polysulfate and avoidance of urethral catheterisation: improved outcomes in children with haemorrhagic cystitis post stem cell transplant/chemotherapy." 10/01/2004 - "To assess the use of sodium pentosan polysulphate (SPP) for haemorrhagic cystitis (HC), a potentially life-threatening side-effect in patients treated with pelvic radiotherapy or cyclophosphamide, and which can be difficult to manage as patients often have significant comorbidity. " 08/01/2015 - "Pentosan polysulfate (PPS) is a glycan derivative that is orally bioavailable, has few toxic side effects, and is currently licensed under the name Elmiron for the treatment of cystitis in the United States. "

Related Drugs and Biologics

1.	Pentosan Sulfuric Polyester (Pentosan Polysulfate)
2.	Heparin (Liquaemin)
3.	Cyclosporine (Ciclosporin)
4.	Sodium
5.	Liposomes (Liposome)
6.	Acenocoumarol
7.	coumarin
8.	Dextran Sulfate
9.	Heparinoids (Heparinoid)
10.	Calcium Oxalate

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Drug Therapy (Chemotherapy)
3.	Therapeutics
4.	Intraperitoneal Injections
5.	Intraventricular Infusions