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Penile Neoplasms (Penile Cancer)

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Cancers or tumors of the PENIS or of its component tissues.

Also Known As:

Penile Cancer; Cancer of the Penis; Neoplasms, Penile; Neoplasms, Penis; Penis Cancer; Penis Neoplasms; Cancer, Penile; Cancer, Penis; Cancers, Penile; Cancers, Penis; Neoplasm, Penile; Neoplasm, Penis; Penile Cancers; Penile Neoplasm; Penis Cancers; Penis Neoplasm; Cancer of Penis

Networked: 413 relevant articles (31 outcomes, 39 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Neoplasm Metastasis (Metastasis)
3.	Carcinoma (Carcinomatosis)
4.	Penile Neoplasms (Penile Cancer)
5.	Urinary Tract Infections (Urinary Tract Infection)

Experts

1.	Horenblas, Simon: 17 articles (11/2015 - 03/2006)
2.	Spiess, Philippe E: 13 articles (11/2015 - 04/2007)
3.	Zhu, Yao: 13 articles (11/2015 - 07/2007)
4.	Pettaway, Curtis A: 12 articles (01/2016 - 04/2002)
5.	Minhas, Suks: 10 articles (01/2015 - 11/2005)
6.	Pagliaro, Lance C: 9 articles (01/2016 - 04/2007)
7.	Hakenberg, Oliver W: 7 articles (01/2015 - 12/2006)
8.	Ye, Ding-Wei: 7 articles (05/2014 - 11/2008)
9.	Protzel, C: 6 articles (12/2015 - 01/2009)
10.	Protzel, Chris: 6 articles (08/2015 - 10/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Penile Neoplasms:

1.	Bleomycin (Blenoxane)FDA LinkGeneric 07/01/1984 - "In addition, data of four patients with penile cancer treated at Memorial Hospital in 1971-72 as part of a drug-oriented prospective Phase I-II trial of bleomycin are included. " 02/26/1971 - "[Bleomycin treatment of cancer of the penis]." 05/01/1969 - "[3 cases of penile cancer--clinical use of a new antineoplastic antibiotic, bleomycin]." 04/01/1989 - "In the chemotherapy of the primary lesion of penile cancer, bleomycin is most effective with a response rate of 60-70%. " 01/01/1970 - "[Penile cancer with marked improvement following bleomycin therapy combined with betatron irradiation; report of a case]."
2.	Cisplatin (Platino)FDA LinkGeneric 08/01/2010 - "Treatment with a cisplatin-containing regimen in Stage IV penile cancer should be considered and might facilitate curative resection. " 04/01/1994 - "This cisplatin pasting would probably be a useful technique in radiotherapy of penile cancer, preserving the function of the organ." 04/01/1994 - "A case of penile cancer (Jackson's stage II) was treated with cisplatin pasta along with radiotherapy. " 04/01/1994 - "Cisplatin pasting for radiotherapy of penile cancer." 07/01/2008 - "The aim of this study is to determine efficacy and feasibility of the combination regimen irinotecan and cisplatin in patients with cisplatin advanced penile cancer. "
3.	Paclitaxel (Taxol)FDA LinkGeneric 12/01/2011 - "Paclitaxel in pretreated metastatic penile cancer: final results of a phase 2 study." 12/01/2011 - "To evaluate the activity and safety of paclitaxel in pretreated metastatic penile cancer. " 04/01/2009 - "Activity and toxicity of paclitaxel in pretreated metastatic penile cancer patients." 12/01/2011 - "Previously published preliminary findings showed promising activity of paclitaxel in chemotherapy-pretreated metastatic penile cancer. " 04/01/2004 - "The paclitaxel/carboplatin combination has potential activity in penile cancer. "
4.	Fluorouracil (Carac)FDA LinkGeneric 09/01/2013 - "This could be helpful for the application of fluorouracil in chemotherapy for the patients with penile cancer." 07/01/2001 - "Primary therapy of penile cancer (carcinoma in situ/T1 tumors) consists of circumcision, microsurgical excision, application of 5-fluorouracil cream, radiation, or laser treatment. " 03/01/1992 - "Cisplatin and 5-fluorouracil in advanced cancer of the penis." 02/01/2014 - "[Neoadjuvant and adjuvant chemotherapy with paclitaxel, cisplatin and 5-fluorouracil for advanced penile cancer: a case report]." 03/01/1992 - "The combination of cisplatin and 5-fluorouracil may have a role in the management of advanced penile cancer together with surgery and radiotherapy."
5.	ParaffinIBA 07/01/2013 - "Formalin-fixed paraffin embedded samples of 26 patients with penile cancer and another 18 cases with non-tumorigenic lesions were stained by three different widely used commercially available chromogenic in-situ hybridization assays high-risk HPV CISH Y1443 (Genpoint, DAKO), pan HPV CISH Y1404 (Genpoint, DAKO), INFORM HPV III (Ventana, Tucson, Arizona) and p16INK4A immunohistochemistry, then compared to the known gold standard polymerase chain reaction detecting HPV 16, 18, 31, and 33. " 01/01/1992 - "This study suggests that flow cytometric determination of nuclear DNA ploidy from paraffin-embedded samples in penile cancer does add an additional prognostic determinant in addition to the clinical staging of tumors." 11/15/1995 - "A total of 117 formalin-fixed, paraffin-embedded specimens of penile cancer from an equal number of patients who had been diagnosed either at the Memorial Sloan-Kettering Cancer Research Center in New York City between 1964 and 1992 or the Universidad Nacional de Asunción in Paraguay between 1980 and 1992 were analyzed. "
6.	Ifosfamide FDA LinkGeneric 08/20/2010 - "Neoadjuvant paclitaxel, ifosfamide, and cisplatin chemotherapy for metastatic penile cancer: a phase II study." 08/20/2010 - "The neoadjuvant regimen of paclitaxel, ifosfamide, and cisplatin induced clinically meaningful responses in patients with bulky regional lymph node metastases from penile cancer." 01/01/2015 - "A case of penile cancer with inguinal metastases that responded well to neoadjuvant chemotherapy with paclitaxel, ifosfamide and cisplatin (TIP) is described. " 01/01/2015 - "[Dramatic response of penile cancer with inguinal lymph node metastases to neoadjuvant chemotherapy with paclitaxel, ifosfamide and cisplatin : a case report]."
7.	CosmeticsIBA 04/01/2015 - "GR and TGN seem to be oncologically safe procedures for treating carefully selected patients with penile cancer, and the functional and cosmetic results are promising. " 12/01/2014 - "Penile preservation is better for functional and cosmetic outcomes and should be offered as a primary treatment method in men with low-stage penile cancer. " 06/01/2011 - "Penile cosmetic preservation in the management of the invasive penile cancer." 12/01/2009 - "Patients with penile cancer sometimes refuse surgery under the consideration of cosmetic and functional impact. " 03/01/2011 - "There is a significant number of patients with penile cancer and/or other penile skin pathologies who can undergo definitive and non-mutilating surgery with excellent oncologic, cosmetic and functional results with skin grafting."
8.	Formaldehyde (Formol)FDA Link 07/01/2013 - "Formalin-fixed paraffin embedded samples of 26 patients with penile cancer and another 18 cases with non-tumorigenic lesions were stained by three different widely used commercially available chromogenic in-situ hybridization assays high-risk HPV CISH Y1443 (Genpoint, DAKO), pan HPV CISH Y1404 (Genpoint, DAKO), INFORM HPV III (Ventana, Tucson, Arizona) and p16INK4A immunohistochemistry, then compared to the known gold standard polymerase chain reaction detecting HPV 16, 18, 31, and 33. " 07/01/2013 - "Archival formalin-fixed material of 123 invasive penile cancers and 43 pre-invasive lesions was evaluated for the presence of LS, LP, 28 HPV genotypes, and expression of p53 and p16(ink4a). " 11/15/1995 - "A total of 117 formalin-fixed, paraffin-embedded specimens of penile cancer from an equal number of patients who had been diagnosed either at the Memorial Sloan-Kettering Cancer Research Center in New York City between 1964 and 1992 or the Universidad Nacional de Asunción in Paraguay between 1980 and 1992 were analyzed. " 07/01/2011 - "Archival formalin-fixed high-grade penile intraepithelial neoplasias, differentiated penile intraepithelial neoplasias, and invasive carcinomas from a single pathology institution in a low-incidence area for penile cancer were analyzed for 28 HPV low-risk and HPV high-risk genotypes, p16 overexpression, presence of peritumoral lichen sclerosus, lichen planus, precursor lesions, and monoclonal rearrangement of the T-cell receptor γ locus. "
9.	squamous cell of head and neck CarcinomaIBA 05/01/1982 - "Bleomycetin was effective in 75-80, 81.8, 58.3, 70 and 50 per cent of the cases with disseminated derminogenic tumor of the testicle, squamous cell carcinoma of the head and neck, cancer of the penis, carcinoma of the skin and lymphogranulomatosis, respectively. "
10.	First StepIBA 05/01/2014 - "To evaluate the efficacy of human amniotic membrane (AM) grafting in the canine penile tunica albuginea defect; we developed an animal model as the first step toward an innovating new method for the treatment of Peyronie's disease, penile cancers, and congenital deformities of the penis. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 02/01/2009 - "The most effective treatment for cancer of the penis is surgery reserving chemotherapy and radiation therapy for the recurrence." 06/01/1988 - "It is clear that this combination therapy was effective against metastatic penile cancer and the role of preoperative chemotherapy is becoming increasingly important in metastatic penile cancer. " 01/01/2015 - "TIP chemotherapy appears to be effective for advanced penile cancer. " 05/01/2015 - "To retrospectively estimate the efficacy of various treatments used in men with metastatic penile cancer that progresses after first-line chemotherapy. " 12/01/2009 - "The efficacy of intra-arterial (IA) chemotherapy for penile cancer has not been well defined. "
2.	Lymph Node Excision (Lymph Node Dissection) 04/01/2014 - "[Inguinal lymphadenectomy for penile cancer: study on the prevention of wound healing complications]." 01/01/2014 - "Ninety-eight men who underwent lymphadenectomy for penile cancer were enrolled in the study. " 01/01/2014 - "The aim of the study was to assess prognostic factors in patients undergoing lymphadenectomy for penile cancer. " 06/01/2013 - "AND WHAT DOES THE STUDY ADD?: Several lymph node staging strategies have been proposed as a response to the high morbidity seen after standard inguinal lymphadenectomy for penile cancer. " 01/01/2013 - "With increasing adoption of minimally invasive surgical techniques in urologic oncology, the efficacy, safety, and adequacy of lymphadenectomy were reviewed for studies about prostate, bladder, kidney, upper tract urothelial, testicular, and penile cancer published in the past 18 months. "
3.	Male Circumcision (Circumcision) 10/01/2012 - "This report suggests that buried penis may pose a risk factor for the development of penile cancer despite the protective effects of neonatal circumcision. " 10/01/2012 - "One of the documented benefits of neonatal circumcision is protection against invasive penile cancer. " 10/29/2005 - "It is unknown whether a causative relationship exists between circumcision and the substantially reduced incidence of penile cancer. " 08/01/2011 - "In contrast, there was some evidence that circumcision in adulthood was associated with an increased risk of invasive penile cancer (summary OR = 2.71; 95% CI 0.93-7.94; 3 studies). " 08/01/2011 - "There was a strong protective effect of childhood/adolescent circumcision on invasive penile cancer (OR = 0.33; 95% CI 0.13-0.83; 3 studies). "
4.	Adjuvant Chemotherapy 09/01/2014 - "Improved outcomes in advanced penile cancer requires an integrated approach, including better identification of high-risk disease, use of novel dynamic sentinel lymph node identification techniques and use of neo-adjuvant chemotherapy in selected patients with advanced lymph node involvement. " 10/01/2007 - "[Neoadjuvant and adjuvant chemotherapy in patients with advanced penile cancer]." 11/01/2013 - "Nevertheless, a curative treatment by medicinal approaches alone does not appear to be possible for metastatic penile cancer and can be only cured by multimodal approaches, including neoadjuvant and adjuvant chemotherapy and salvage lymph node dissection. " 11/01/2015 - "Adjuvant chemotherapy is associated with improved overall survival in pelvic node-positive penile cancer after lymph node dissection: A multi-institutional study." 11/01/2015 - "We determined whether adjuvant chemotherapy (AC) would be associated with improved survival after lymph node dissection (LND) for patients with penile cancer (PeCa) who have positive pelvic lymph nodes (PPLNs). "
5.	Radiotherapy 11/03/1986 - "We report the case of a patient with locally-advanced penile cancer and metastatic inguinal adenopathy who has been cured by radiotherapy. " 05/01/2015 - "The role of radiotherapy in the management of penile cancer." 08/01/2011 - "We studied the outcomes in patients with node positive penile cancer who received radiotherapy to inguinal and pelvic nodes. " 08/01/2011 - "Radiotherapy for node positive penile cancer: experience of the Leeds teaching hospitals." 05/01/2011 - "Penile cancer: are there currently indications for radiotherapy?."