HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Penile Induration (Peyronie's Disease)

Subscribe to New Research on Penile Induration

A condition characterized by hardening of the PENIS due to the formation of fibrous plaques on the dorsolateral aspect of the PENIS, usually involving the membrane (tunica albuginea) surrounding the erectile tissue (corpus cavernosum penis). This may eventually cause a painful deformity of the shaft or constriction of the urethra, or both.

Also Known As:

Peyronie's Disease; Peyronie Disease; Penile Fibromatosis; Plastic Induration of the Penis; Cavernitides, Fibrous; Fibromatosis, Penile; Fibrous Cavernitides; Fibrous Cavernitis; Peyronies Disease; Cavernitis, Fibrous

Networked: 622 relevant articles (56 outcomes, 101 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Erectile Dysfunction
3.	Congenital Abnormalities (Deformity)
4.	Penile Neoplasms (Penile Cancer)
5.	Infection

Experts

1.	Levine, Laurence A: 20 articles (01/2015 - 03/2002)
2.	Hellstrom, Wayne J G: 17 articles (12/2015 - 07/2003)
3.	Rajfer, Jacob: 11 articles (09/2010 - 03/2002)
4.	Gonzalez-Cadavid, Nestor F: 10 articles (09/2010 - 03/2002)
5.	Lue, Tom F: 8 articles (01/2015 - 07/2002)
6.	Mulhall, John P: 8 articles (01/2014 - 12/2002)
7.	Seftel, Allen D: 7 articles (11/2015 - 08/2012)
8.	Hellstrom, W J: 7 articles (08/2015 - 05/2000)
9.	Bivalacqua, T J: 7 articles (09/2014 - 06/2000)
10.	Brock, Gerald B: 7 articles (11/2013 - 09/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Penile Induration:

1.	Verapamil (Calan)FDA LinkGeneric 05/01/2007 - "The dilution of verapamil significantly improved its efficacy in improving Peyronie's disease symptoms." 01/01/2009 - "Although in some studies verapamil has been found to be effective in the treatment of Peyronie's disease, we did not find any improvement in comparison with the control group. " 03/01/2007 - "Transdermal and intralesional verapamil has been reported to be useful in the treatment of Peyronie's Disease. " 09/01/1998 - "We have demonstrated that intraplaque verapamil injection is a promising treatment for Peyronie's disease in that it may circumvent surgical intervention and may be used with concurrent therapies." 01/01/2013 - "To our knowledge this novel study offers for the first time histological evidence of cellular changes and improvement in penile pressure studies in rats with Peyronie plaque after intralesional verapamil injection therapy in a Peyronie disease animal model."
2.	InterferonsIBA 11/01/2009 - "Injection therapy, primarily with interferon, seems to be the most promising treatment for early stage Peyronie's disease. " 11/01/2009 - "Intralesional interferon therapy has shown to result in significant improvement in Peyronie's disease plaques and curvature. " 01/01/1997 - "In this clinical study, to determine the therapeutic efficacy of interferon (IFN) treatment for Peyronie's disease, we applied interferon alpha-2A (IFN alpha-2A) intralesionally in the treatment of Peyronie plaques in 15 patients and results were evaluated by magnetic resonance imaging (MRI). " 07/01/2006 - "This single-blind, multicenter, placebo controlled, parallel study demonstrates that intralesional interferon alpha-2b at a dose of 5 x 10(6) units biweekly for 12 weeks is effective and safe as minimally invasive therapy for Peyronie's disease." 01/01/2007 - "Is intralesional interferon alpha2b a safe and effective minimally invasive treatment for Peyronie's disease?"
3.	Vitamin E FDA LinkGeneric 01/01/2013 - "Efficacy of vitamin E in the conservative treatment of Peyronie's disease: legend or reality? " 01/01/2006 - "Does smoking change the efficacy of combination therapy with vitamin E and colchicines in patients with early-stage Peyronie's disease?" 01/01/2006 - "This study was conducted to find out if smoking has an effect on the results of combination therapy with vitamin E and colchicines in patients with early-stage Peyronie's disease (PD). " 03/01/2006 - "We could not confirm the benefit of vitamin E for Peyronie's disease. " 01/01/1987 - "[Conservative therapy of Peyronie's disease using vitamin E]."
4.	Dexamethasone (Maxidex)FDA LinkGeneric 12/01/1975 - "The results in 21 patients with Peyronie's disease who were managed with a course of dermo-jet percutaneous injections of dexamethasone into the plaques are described herein. " 12/01/1975 - "Peyronie's disease: results with dermo-jet injection of dexamethasone." 06/01/2003 - "The transdermal electromotive administration of verapamil and dexamethasone is clinically safe and appears to be an effective treatment in patients with Peyronie's disease." 01/01/2013 - "To compare the efficacy of transdermal electromotive administration and intra-lesional injection of verapamil plus dexamethasone for the treatment of Peyronie's disease. " 04/01/2004 - "Uncontrolled studies with intraplaque electromotive administration of verapamil and dexamethasone have demonstrated objective improvements in Peyronie's disease. "
5.	Microbial Collagenase (Clostridiopeptidase A)IBA 11/01/2015 - "Re: Clinical Efficacy of Collagenase Clostridium Histolyticum in the Treatment of Peyronie's Disease by Subgroup: Results from two Large, Double-Blind, Randomized, Placebo-Controlled, Phase III Studies." 11/01/2015 - "Re: Clinical Efficacy of Collagenase Clostridium histolyticum in the Treatment of Peyronie's Disease by Subgroups: Results from Two Large, Double-blind, Randomized, Placebo-controlled, Phase III Studies." 10/01/2015 - "Clinical efficacy of collagenase Clostridium histolyticum in the treatment of Peyronie's disease by subgroup: results from two large, double-blind, randomized, placebo-controlled, phase III studies." 10/01/2015 - "To examine the efficacy of intralesional collagenase Clostridium histolyticum (CCH) in defined subgroups of patients with Peyronie's disease (PD). " 01/01/2015 - "Clinical safety and effectiveness of collagenase clostridium histolyticum injection in patients with Peyronie's disease: a phase 3 open-label study."
6.	Colchicine FDA LinkGeneric 08/01/1994 - "Is colchicine effective in Peyronie's disease? " 08/01/1994 - "Although this pilot study shows some promising results of the use of colchicine in the treatment of Peyronie's disease, the ultimate usefulness of this agent will be determined only by a prospective double-blind clinical study." 01/01/2003 - "Colchicine has been reported to be a safe and effective medication in the treatment of early phase of Peyronie's disease (PD). " 06/01/2004 - "Therapeutic effects of colchicine in the management of Peyronie's disease: a randomized double-blind, placebo-controlled study." 06/01/2000 - "As recent clinical and animal studies have indicated, colchicine, with its anti-fibrotic, anti-mitotic and anti-inflammatory activities, has suppressive effects in the pathogenesis of Peyronie's disease. "
7.	Interferon-alpha (Interferon Alfa)FDA Link 05/01/2001 - "To evaluate the efficacy of subcutaneous interferon-alpha 2b in the treatment of Peyronie's disease. " 05/01/2001 - "However, with no objective reduction in penile deviation and plaque size, the outcome of interferon-alpha 2b therapy is generally unconvincing and the drug cannot be recommended for the conservative treatment of Peyronie's disease." 05/01/2001 - "Treatment of Peyronie's disease with local interferon-alpha 2b." 07/01/1999 - "A pilot study demonstrating clinical benefit from intralesional interferon alpha 2B in the treatment of Peyronie's disease." 01/01/1997 - "Local interferon-alpha 2b is not an effective treatment in early-stage Peyronie's disease."
8.	Pentoxifylline (Trental)FDA LinkGeneric 07/01/2010 - "To analyse the safety and efficacy of pentoxifylline sustained-release (PTX-SR) treatment in patients with early chronic Peyronie's disease (PD). " 09/01/2014 - "Efficacy of pentoxifylline in Peyronie's disease: Clinical case of a young man." 03/01/2015 - "Retraction statement: A double-blind placebo-controlled study of the efficacy and safety of pentoxifylline in early chronic Peyronie's disease." 07/01/2010 - "A double-blind placebo-controlled study of the efficacy and safety of pentoxifylline in early chronic Peyronie's disease." 03/01/2011 - "Pentoxifylline treatment and penile calcifications in men with Peyronie's disease."
9.	Tamoxifen FDA LinkGeneric 12/01/1992 - "This is a preliminary study of the treatment of 36 patients with Peyronie's disease who received tamoxifen 20 mg twice daily for 3 months. " 12/01/1999 - "We evaluated the effects of oral tamoxifen and placebo in patients with Peyronie's disease. " 12/01/1999 - "Tamoxifen versus placebo in the treatment of Peyronie's disease." 12/01/1992 - "The treatment of Peyronie's disease with tamoxifen." 12/01/1999 - "This study did not show significant improvement in pain, curvature or plaque size in patients with Peyronie's disease who were treated with tamoxifen compared with those treated with placebo."
10.	Lidocaine (Xylocaine)FDA LinkGeneric 04/01/2004 - "Intraplaque electromotive verapamil and dexamethasone induce substantial objective improvement in Peyronie's disease compared to electromotive lidocaine administration." 01/01/2000 - "We evaluate the efficacy of iontophoresis of dexamethasone, lidocaine and verapamil to treat Peyronie's disease. " 01/01/2000 - "Forty patients with Peyronie's disease were treated by electromotive administration of the 3-drug association orgotein-dexamethasone-lidocaine in a double-blind, placebo-controlled, partial crossover study (study 1). " 01/01/2000 - "Iontophoresis of dexamethasone, lidocaine and verapamil may be regarded as first line nonsurgical treatment for Peyronie's disease." 12/01/2000 - "The aim of this study was to assess the effect of local injections of betamethasone, hyaluronidase and lidocaine in patients with Peyronie's disease. "

Therapies and Procedures

1.	Penile Prosthesis (Penile Implants) 01/01/2008 - "We can conclude that SSDA penile prosthesis is safe and effective in Peyronie's disease." 10/01/1994 - "A new treatment for Peyronie's disease: modeling the penis over an inflatable penile prosthesis." 01/01/2008 - "This study included 12 men with Peyronie's disease who underwent placement of a penile prosthesis. " 06/01/2006 - "This study included 64 men with Peyronie's disease who underwent placement of a penile prosthesis. " 11/01/2004 - "In 61% of patients with combined Peyronie's disease/ED in this study, the placement of a three-piece inflatable penile prosthesis alone corrected the penile curvature. "
2.	Intralesional Injections 08/01/2015 - "Although further studies assessing the long-term effects of CCH intralesional injection are needed, current evidence indicates that this is a minimally invasive, effective and generally well tolerated treatment option for patients with Peyronie's disease." 12/01/2015 - "Comparative analysis of tunical plication vs. intralesional injection therapy for ventral Peyronie's disease. " 12/01/2015 - "Comparative Analysis of Tunical Plication vs. Intralesional Injection Therapy for Ventral Peyronie's Disease." 12/01/2015 - "Intralesional Injection of Interferon-α2b Improves Penile Curvature in Men with Peyronie's Disease Independent of Plaque Location." 07/01/2015 - "Intralesional Injections for Early Peyronie Disease: Standardized Assessment and Analysis of Predictive Factors for Treatment Response."
3.	Prostheses and Implants (Prosthesis) 01/01/1997 - "The results suggest that the surgical implantation of the newer model prosthesis as a treatment for Peyronie's disease offers a highly successful therapy with low morbidity." 05/01/2004 - "Because of the better understanding of the basic sciences of the disease, earlier diagnosis and improved medical and surgical treatment, currently patients with Peyronie's disease have a wider range of therapeutic options and may experience a better prognosis, with only few of them in need of prosthesis surgery. " 04/01/2015 - "In MVA, Caucasian race, Peyronie's disease, and private insurance were independently associated with receipt of an inflatable prosthesis. " 01/01/2008 - "The aim of this retrospective study is to evaluate the long-term followup of soft penile SSDA prosthesis, without plaque surgery in the treatment of Peyronie's disease. " 02/01/2005 - "Soft prosthesis implant and relaxing albugineal incision with saphenous grafting for surgical therapy of Peyronie's disease: a 5-year experience and long-term follow-up on 145 operated patients."
4.	Transplants (Transplant) 11/01/2006 - "Early intervention in the traumatic penis gives better results whereas the Nesbit operation is still the gold standard for Peyronie's disease as the quest for an alternative graft to saphenous vein continues. " 01/01/2004 - "To study the value of an acellular matrix graft of the tunica albuginea for reconstruction of the penis in cases of severe Peyronie's disease. " 01/01/2004 - "Tunica albuginea acellular matrix graft for treatment of Peyronie's disease--an experimental study in dogs." 08/01/2003 - "This study is to assess the feasibility of the deep dorsal vein graft in repairing the defect after plaque incision for Peyronie's disease in Taiwanese men. " 04/01/2002 - "To study the surgical treatment of Peyronie's disease using a single incision in the tunica albuginea and fibrotic plaque and repair of the defect by bovine pericardium graft. "
5.	Injections 10/01/2015 - "Considering the minimally invasive approach in this study, the absence of major side effects, and the significant treatment outcomes achieved, we conclude that intralesional penile injections with HA are effective for treating Peyronie's disease." 12/01/2015 - "Sexual dysfunction: CCH injections regarded effective by men with Peyronie's disease." 09/01/2009 - "Basing on the experience with these cases the following conclusions were made: intraplaque injections are hard to perform and can provoke progression of the disease; long-term conservative treatment for stabilization of the active stage of Peyronie's disease can lead to shortening of the penis; in malignant course of the disease and progressive shortening of the penis surgical policy is justified despite "acute" phase of the disease." 03/01/2007 - "We performed a search of peer-reviewed literature looking at all agents used to treat Peyronie's disease by intraplaque injections. " 01/01/2004 - "Intralesional interferon-alpha-2B injections for the treatment of Peyronie's disease."