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Penicillin G Procaine (Procaine, Benzylpenicillin)

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Semisynthetic antibiotic prepared by combining penicillin G with PROCAINE.

Also Known As:

Procaine, Benzylpenicillin; Benzylpenicillin Procaine; Jenacillin; Procaine Penicillin; G Procaine, Penicillin; Penicillin, Procaine; Procaine, Penicillin G; 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenylacetyl)amino)- (2S-(2alpha,5alpha,6beta))-, compd. with 2-(diethylamino)ethyl 4-aminobenzoate (1:1), monohydrate

Networked: 311 relevant articles (28 outcomes, 31 trials/studies)

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Drug Context: Research Results

Experts

1.	Cousens, Simon: 4 articles (05/2015 - 09/2013)
2.	Anyabolu, Chineme Henry: 2 articles (05/2015 - 05/2015)
3.	Ngaima, Serge: 2 articles (05/2015 - 05/2015)
4.	Wammanda, Robinson D: 2 articles (05/2015 - 05/2015)
5.	African Neonatal Sepsis Trial (AFRINEST) group: 2 articles (05/2015 - 05/2015)
6.	Ayede, Adejumoke Idowu: 2 articles (05/2015 - 05/2015)
7.	Lokangaka, Adrien: 2 articles (05/2015 - 05/2015)
8.	Ogala, William N: 2 articles (05/2015 - 05/2015)
9.	Adejuyigbe, Ebunoluwa A: 2 articles (05/2015 - 05/2015)
10.	Falade, Adegoke Gbadegesin: 2 articles (05/2015 - 05/2015)

Related Diseases

1.	Infection 05/01/1989 - "After 30 days from the infection all animals were given procaine penicillin in daily doses of 75,000 mu/kg. The treatment was carried on for 20 days. " 08/01/1988 - "His condition responded briskly to treatment with procaine penicillin, and we conclude that the clinical features were attributable to infection with Treponema pallidum." 01/01/1985 - "Treatment with procaine penicillin, 300,000 U every 12 hr, was begun one to two days after infection. " 12/01/1979 - "Familiar antecedents, mechanism of infection, clinical symptoms and radiological findings are analized, emphasizing the importance of prophylaxis and early treatment with procaine penicillin in a dosage of 50,000 U./Kg. day for at least ten days." 12/01/1979 - "Treatment failure occurred in three patients given a single dose of aqueous procaine penicillin 2.4 megaunits intramuscularly, two of whom had rectal infections; no treatment failures occurred in patients with pharyngeal infections. "
2.	Gonorrhea 09/01/1987 - "The high endemicity of both types of resistance in some regions precludes the continued routine use of procaine penicillin (APPG) as treatment for gonorrhea. " 03/21/1980 - "The intramuscular (IM) injection of penicillin G procaine, 4.8 million units, with 1 g of probenicid given orally is the treatment of choice for anorectal gonorrhea. " 03/01/1972 - "Public Health Service-recommended dosages of aqueous procaine penicillin G in the treatment of uncomplicated gonorrhea in 353 men and 314 women. " 03/01/1971 - "Effect of double dose of aqueous procaine penicillin to treat gonorrhea in men." 06/02/1961 - "[Therapy of uncomplicated gonorrhea with procaine penicillin]."
3.	Syphilis 10/01/1985 - "The condylomata lata responded well to treatment of the syphilis with procaine penicillin G." 09/10/1999 - "Compared with short-acting procaine penicillin G, BPG has a longer half-life considered essential for effective syphilis treatment because it yields sustained spirochetecidal levels needed to treat the slowly reproducing agent of syphilis, Treponema pallidum. " 11/09/1980 - "[Neonatal syphilis and procaine penicillin]." 11/01/1963 - "[RESULTS OF PROCAINE PENICILLIN TREATMENT OF RECENT SYPHILIS]." 03/01/1955 - "[Treatment of syphilis with procaine penicillin preparations]."
4.	Pneumonia (Pneumonitis) 07/01/1956 - "Pneumonia in children; treatment with one single injection of procaine penicillin compared with continuous treatment." 08/15/1952 - "[Single dose procaine penicillin injection for pneumonia in children]." 03/01/1948 - "Procaine penicillin G in oil; plasma concentrations; preliminary observations in its use in pneumonia." 02/01/1987 - "Our findings lend support to the World Health Organization recommendation that children with mild pneumonia in developing countries be given daily intramuscular injections of 50,000 U/kg aqueous procaine penicillin." 01/01/2012 - "Procaine benzylpenicillin, for treatment of pediatric pneumonia and neonatal sepsis, was on 50% (45/89) of the lists. "
5.	Hypersensitivity (Allergy) 04/01/1998 - "Fifteen of 17 patients were cured with procaine penicillin, one presented allergy, and one was a therapeutic failure. " 06/01/2001 - "These clinical observations indicate also that using term "acute non-allergic reaction to procaine penicillin G" as synonym of Hoigne syndrome is not precise. " 11/01/1994 - "The effect of a acute non-allergic reaction occurring after injection of procaine penicillin on the occurrence of different neurotic symptoms is a subject of the paper. " 02/01/1976 - "[Acute non-allergic reactions to procaine penicillin (Hoigne's syndrome)]." 09/21/1974 - "Letter: Acute non-allergic reaction to aqueous procaine penicillin."

Related Drugs and Biologics

1.	Penicillins (Penicillin)
2.	Probenecid (Benemid)
3.	Gentamicins (Gentamicin)
4.	Penicillin G (Benzylpenicillin)
5.	Ampicillin (Omnipen)
6.	Penicillin G Benzathine (LPG)
7.	Streptomycin (Streptomycin Sulfate)
8.	Oxytetracycline (Terramycin)
9.	Spiramycin
10.	Doxycycline (Vibramycin)

Related Therapies and Procedures

1.	Injections
2.	Intramuscular Injections
3.	Subcutaneous Injections
4.	Chemoprevention
5.	Oral Administration