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Penicillin G Benzathine (LPG)

Subscribe to New Research on Penicillin G Benzathine

Semisynthetic antibiotic prepared by combining the sodium salt of penicillin G with N,N'-dibenzylethylenediamine.

Also Known As:

LPG; Benzathine Benzylpenicillin; Bicillin; Permapen; Benzathine Penicillin; Antibioticos Brand of Benzathine Benzylpenicillin; Antibioticos Farma Brand of Penicillin G Benzathine; Bayer Brand of Benzathine Benzylpenicillin; Bencelin; Benzathine Benzylpénicilline Panpharma; Benzetacil; Bicillin L-A; Brevicilina; CSL Brand of Benzathine Benzylpenicillin; Cepacilina; Debecillin; Extencilline; I Farmacologia Brand of Benzathine Benzylpenicillin; Jenapharm Brand of Benzathine Benzylpenicillin; King Pharmaceuticals Brand of Penicillin G Benzathine; Panpharma Brand of Benzathine Benzylpenicillin; Pendepon; Penduran; Pendysin; Penidural; Peniroger Retard; Provipen Benzatina; Roerig Brand of Benzathine Benzylpenicillin; Roger Brand of Benzathine Benzylpenicillin; Sabater Brand of Benzathine Benzylpenicillin; Sandoz Brand of Penicillin G Benzathine; Specia Brand of Benzathine Benzylpenicillin; Tardocillin; Wassermann Brand of Benzathine Benzylpenicillin; Wyeth Brand of Penicillin G Benzathine; Yamanouchi Brand of Benzathine Benzylpenicillin; Benzathine, Penicillin G; Benzylpenicillin, Benzathine; Bicillin L A; Bicillin LA; G Benzathine, Penicillin; Penicillin, Benzathine; 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenylacetyl)amino)- (2S-(2alpha,5alpha,6beta))-, compd. with N,N'-bis(phenylmethyl)-1,2-ethanediamine (2:1)

Networked: 692 relevant articles (47 outcomes, 74 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Beverley, Stephen M: 7 articles (12/2015 - 08/2003)
2.	Saito, Takao: 6 articles (04/2014 - 02/2002)
3.	Turco, S J: 6 articles (02/2004 - 01/2000)
4.	Turco, Salvatore J: 5 articles (12/2015 - 08/2003)
5.	Yang, Chia-Jui: 5 articles (05/2015 - 10/2013)
6.	Hung, Chien-Ching: 5 articles (05/2015 - 10/2013)
7.	Mbati, P A: 5 articles (02/2006 - 02/2001)
8.	Tonui, W K: 5 articles (02/2006 - 02/2001)
9.	Matsunaga, Akira: 4 articles (04/2014 - 02/2006)
10.	Orago, A S: 4 articles (02/2004 - 02/2001)

Related Diseases

1.	Syphilis 07/15/2015 - "Intramuscular benzathine penicillin G (BPG) is widely used for the treatment of syphilis. " 02/15/2015 - "A single dose of benzathine penicillin G is as effective as multiple doses of benzathine penicillin G for the treatment of HIV-infected persons with early syphilis." 06/11/1976 - "The results of the study confirm the efficacy of one-shot treatment of the syphilis by administration of 2,400,000 to units of benzathine penicillin." 01/01/2002 - "This may be with respect to efficacy, for example in syphilis with single-dose benzathine penicillin therapy, particularly for pregnant women and individuals infected with HI. " 01/01/2012 - "Further studies on the utility of benzathine penicillin G for early syphilis are warranted."
2.	Rheumatic Fever (Acute Articular Rheumatism) 03/01/2015 - "Secondary prophylaxis with monthly injection of benzathine penicillin is effective in preventing recurrence of acute rheumatic fever and worsening of RHD, but adherence rates are poor in Uganda. " 03/01/2000 - "Benzathine penicillin G (BPG) is effective for secondary prophylaxis of rheumatic fever (RF). " 12/01/2004 - "(4) Comparative trials done in the 1950s showed that benzathine benzylpenicillin helped prevent acute rheumatic fever, reducing the risk by about 75%. " 08/01/2004 - "Previous in vivo studies using sister chromatid exchange (SCE) frequency and comet assay, had showed that long-term administration of benzathine penicillin G may cause some degree of DNA damage in children with rheumatic fever. " 06/01/2001 - "Thirty-five children with confirmed rheumatic fever under benzathine penicillin prophylaxis were enrolled in the study and 35 healthy children with similar ages and socioeconomic backgrounds served as controls. "
3.	Infection 02/01/2004 - "These findings showed that anti-LPG MABS were effective in reducing sand fly infections. " 06/01/2013 - "In this study, we report that in-vitro infection of macrophages with a L. major parasite with high expression levels of LPG results in decreased TLR-9 expression compared to infection with a L. major parasite with lower expression levels of LPG. " 12/01/2015 - "major or purified LPG induced high levels of IL12B subunit gene transcripts in hDCs, which was abrogated with FV1 lpg1- infections. " 09/01/2014 - "In association with Extencilline treatment, intra uterine transfusion can limit consequences of infection. " 06/01/2014 - "The diagnostic sensitivity of a single stool sample was about 75% for individuals with low-intensity infections (⩽1 LPG) and increased to 95% for those with high-intensity infections (⩾10 LPG). "
4.	Pharyngitis (Sore Throat) 06/01/1998 - "To assess the efficacy of benzathine penicillin G (BPG) prophylaxis in recurrent streptococcal pharyngitis in children. " 05/01/1987 - "Efficacy of benzathine penicillin G in group A streptococcal pharyngitis: reevaluation." 04/01/2006 - "The success of the control programmes depends upon timely primary prophylaxis with benzathine penicillin for which a microbiological confirmation of group A streptococcal pharyngitis is essential. " 06/01/1998 - "Seasonal benzathine penicillin G prophylaxis for recurrent streptococcal pharyngitis in children." 11/01/1992 - "GABHS prevalence in Navy recruits receiving single-dose benzathine penicillin prophylaxis was assessed during spring and fall 1989 by culturing throat specimens from randomly selected groups of approximately 230 men before and 2, 4, and 7 weeks after prophylaxis and from men with pharyngitis diagnosed at sick call. "
5.	Congenital Syphilis (Hutchinson's Teeth) 10/15/2002 - "Currently recommended doses of benzathine penicillin G are effective in preventing congenital syphilis in most settings, although studies are needed regarding increased dosing regimens. " 01/01/1997 - "Although the exact failure rate is unknown, benzathine penicillin is effective in preventing symptomatic congenital syphilis when administered to high-risk newborns." 01/01/1997 - "To determine the efficacy of single-dose benzathine penicillin G in infants at high risk of congenital syphilis. " 01/01/1997 - "Single-dose benzathine penicillin in infants at risk of congenital syphilis--results of a randomised study." 01/01/2013 - "The risk of treating pregnant women with benzathine penicillin to prevent congenital syphilis appears very low and does not outweigh its benefits. "

Related Drugs and Biologics

1.	Penicillins (Penicillin)
2.	Azithromycin (Zithromax)
3.	Penicillin G Procaine (Procaine, Benzylpenicillin)
4.	lipophosphonoglycan
5.	Penicillin V (Phenoxymethylpenicillin)
6.	Amoxicillin (Wymox)
7.	Penicillin G (Benzylpenicillin)
8.	Aspirin (Acetylsalicylic Acid)
9.	secondary Syphilis
10.	Oxytetracycline (Terramycin)

Related Therapies and Procedures

1.	Injections
2.	Intramuscular Injections
3.	Subcutaneous Injections
4.	Heterologous Transplantation (Xenotransplantation)
5.	Oral Administration