HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Penicillin G (Benzylpenicillin)

Subscribe to New Research on Penicillin G

A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.

Also Known As:

Benzylpenicillin; Or-pen; Pfizerpen; Antibioticos Brand of Penicillin G Sodium; Benpen; Benzylpenicillin Potassium; Bioniche Brand of Penicillin G Sodium; Britannia Brand of Penicillin G Sodium; CEPA Brand of Penicillin G Sodium; CSL Brand of Penicillin G Sodium; Clonmel Brand of Penicillin G Sodium; Coliriocilina; Crystapen; Ern Brand of Penicillin G Sodium; Grünenthal Brand of Penicillin G Potassium; Jenapharm Brand of Penicillin G Sodium; Lakeside Brand of Penicillin G Sodium; Llorente Brand of Penicillin G Sodium; Medical Brand of Penicillin G Potassium; Medical Brand of Penicillin G Sodium; Normon Brand of Penicillin G Sodium; Ortega Brand of Penicillin G Potassium; Parcillin; Parmed Brand of Penicillin G Potassium; Pekamin; Pengesod; Penibiot; Penicilina G Llorente; Penicillin G Jenapharm; Penicillin G Potassium; Penicillin G Sodium; Penicillin Grünenthal; Penilevel; Peniroger; Pfizer Brand of Penicillin G Potassium; Sodiopen; Sodipen; Sodium Benzylpenicillin; Sodium Penicillin; UCB Brand of Penicillin G Sodium; Unicilina; Ursopen; Van-Pen-G; Vangard Brand of Penicillin G Potassium; 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenylacetyl)amino)- (2S-(2alpha,5alpha,6beta))-

Networked: 1124 relevant articles (99 outcomes, 78 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Torres, M J: 8 articles (08/2015 - 09/2001)
2.	Blanca, M: 8 articles (08/2015 - 09/2001)
3.	Mayorga, C: 5 articles (08/2015 - 09/2001)
4.	Turgut, Mehmet: 5 articles (04/2007 - 03/2004)
5.	Uyanikgil, Yiğit: 5 articles (04/2007 - 03/2004)
6.	Baka, Meral: 4 articles (04/2007 - 03/2004)
7.	Zdziarski, Przemysław: 4 articles (01/2006 - 01/2002)
8.	Macy, Eric: 3 articles (08/2015 - 08/2010)
9.	Araújo, Marcelo: 3 articles (01/2015 - 01/2011)
10.	Simbalista, Raquel: 3 articles (01/2015 - 01/2011)

Related Diseases

1.	Infection 01/01/2015 - "Prompt treatment with intravenous penicillin G is highly effective in resolving the infection." 11/01/2007 - "Despite increasing resistance in the pneumococcus over the past 30 years, there are few cases of treatment failure of non-meningeal infections with high-dosage parenteral penicillin G, which still remains highly effective for many pneumococcal diseases. " 01/01/2002 - "Combination with benzylpenicillin resulted in statistically significant reduction of infections frequency among oncological patients." 08/01/2015 - "psittaci persistent infection cell model was induced by penicillin G, and real-time quantitative PCR was used to study the transcriptional levels of 10 C. " 09/10/1964 - "CLINICAL AND BACTERIOLOGIC STUDIES OF THE EFFECT OF "MASSIVE" DOSES OF PENICILLIN G ON INFECTIONS CAUSED BY GRAM-NEGATIVE BACILLI."
2.	Endocarditis 01/01/1990 - "The rabbit model of endocarditis was used to investigate the efficacy of a high dose regimen of benzylpenicillin (250 mg/kg; peak serum concentration c. " 04/01/2008 - "Penicillin G-resistant viridans group streptococcal endocarditis and interpretation of the American Heart Association's Guidelines for the Treatment of Infective Endocarditis." 03/01/2001 - "A case of isolated pulmonic valve endocarditis caused by group B streptococcus, Streptococcus agalactiae, is presented that was diagnosed with multiplane transesophageal echocardiography in a 40-year old, alcoholic, malnourished man, who was successfully treated with intravenous penicillin G. " 09/01/1998 - "The patient has also been administered Penicillin G for 5 months to treat endocarditis. " 11/01/1994 - "Postantibiotic effects and postantibiotic sub-MIC effects of benzylpenicillin on viridans streptococci isolated from patients with infective endocarditis."
3.	Pneumonia (Pneumonitis) 02/01/1979 - "The elevated doses of benzylpenicillin proved to be effective in 78 per cent of the cases, the effect being observed in all the cases with acute pneumonia, in 88.5 per cent of the cases with neglected state and in 83 per cent of the cases with chronic pneumonia. " 04/01/1984 - "Efficacy of continuous versus intermittent administration of penicillin G in Streptococcus pneumoniae pneumonia in normal and immunodeficient rats." 01/01/2014 - "Retrospective analysis of the efficacies of two different regimens of aqueous penicillin G administered to children with pneumonia." 01/01/2011 - "Outcome of children hospitalized with community-acquired pneumonia treated with aqueous penicillin G." 01/01/2001 - "Only in 1 patients with severe pneumonia and secondary bacteriemia the pneumococcal isolates were moderately resistant to benzylpenicillin (the MIC of 0.125 mg/ml). "
4.	Sepsis (Septicemia) 04/01/2002 - "We assessed neonatal sepsis from GBS and other organisms with use of a before-after study design to evaluate the effects of implementation of combined intrapartum antimicrobial prophylaxis given selectively to mothers with GBS risks and penicillin G given to all neonates. " 08/01/2008 - "Intrapartum penicillin G prophylaxis aims to prevent early-onset group B streptococci (GBS) sepsis by interrupting vertical transmission. " 01/01/2011 - "We performed a post-hoc analysis of a pharmacokinetic (PK) study of penicillin-G, enrolling 18 neonates with a birth weight of <1,200 g, gestational age of <28 weeks and postnatal age of <5 days, with a risk of early onset sepsis. " 07/04/1992 - "[Spondylodiscitis in a cirrhotic patient with penicillin G tolerant Streptococcus bovis septicemia]." 02/01/1982 - "By contrast, even with "late" administration the combined treatment with dexamethasone and benzylpenicillin was effective against lethal pneumococcal sepsis (1 of 14 killed)."
5.	Meningitis 03/01/2006 - "We carried out a study for the nonculture detection of susceptibility of Neisseria meningitis to penicillin G in three laboratories of the European Monitoring Group on Meningococci (EMGM). " 05/01/2012 - "CyP inhibits cytokine production in an in vitro meningitis model and augments the anti-inflammatory response when combined with benzylpenicillin. " 02/01/2011 - "The increasing prevalence of pneumococci meningitis with reduced sensitivity to penicillin G strains isolated from meningitis makes adequate therapeutic management difficult." 07/05/2010 - "In the non-meningitis group no penicillin G nonsusceptible strains were detected. " 07/05/2010 - "Penicillin G resistance was observed in 3.1% of meningitis cases. "

Related Drugs and Biologics

1.	Penicillins (Penicillin)
2.	Gentamicins (Gentamicin)
3.	Ceftriaxone (Ceftriaxon)
4.	Vancomycin
5.	Streptomycin (Streptomycin Sulfate)
6.	Cefotaxime (Kendrick)
7.	Anti-Bacterial Agents (Antibiotics)
8.	Chloramphenicol (Chloromycetin)
9.	Clindamycin (Cleocin)
10.	Imipenem

Related Therapies and Procedures

1.	Amputation
2.	Oral Administration
3.	Remission Induction
4.	Ovariectomy (Oophorectomy)
5.	Drug Therapy (Chemotherapy)