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Penicillamine (Cuprimine)

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3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.

Also Known As:

Cuprimine; D-Penicillamine; Copper Penicillaminate; Cuprenil; D-3-Mercaptovaline; Metalcaptase; D 3 Mercaptovaline; D Penicillamine; Penicillaminate, Copper; beta,beta Dimethylcysteine; Dimethylcysteine; Mercaptovaline; beta,beta-Dimethylcysteine; D-Valine, 3-mercapto-

Networked: 2349 relevant articles (128 outcomes, 206 trials/studies)

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Drug Context: Research Results

Experts

1.	Mumper, Russell J: 5 articles (06/2010 - 02/2005)
2.	Clements, P J: 5 articles (04/2004 - 11/2000)
3.	Gupte, Anshul: 4 articles (02/2009 - 02/2005)
4.	Brewer, George J: 4 articles (02/2006 - 03/2003)
5.	Medsger, T A: 4 articles (06/2001 - 11/2000)
6.	Furst, D E: 4 articles (06/2001 - 11/2000)
7.	Dzieżyc, Karolina: 3 articles (10/2015 - 02/2014)
8.	Litwin, Tomasz: 3 articles (10/2015 - 02/2014)
9.	Członkowska, Anna: 3 articles (10/2015 - 02/2014)
10.	van den Ingh, Ted S G A M: 3 articles (01/2015 - 06/2013)

Related Diseases

1.	Rheumatoid Arthritis 07/01/1985 - "In 52 patients with severe rheumatoid arthritis the therapeutic efficacy of 600 mg/die of D-penicillamine was evaluated for two years in a prospective trial. " 09/01/1994 - "Intermittent treatment with D-penicillamine is effective in lower doses and with fewer adverse effects in patients with rheumatoid arthritis." 10/14/1988 - "D-penicillamine is also effective in controlling the signs and symptoms of rheumatoid arthritis, but serious toxicity may occur. " 01/01/1988 - "The mechanism by which D-Penicillamine is effective in the treatment of rheumatoid arthritis has been investigated. " 11/01/1986 - "In 34 patients with severe rheumatoid arthritis the therapeutic efficacy of 600 mg/die of D-penicillamine was evaluated for five years. "
2.	Hepatolenticular Degeneration (Wilson's Disease) 05/01/2009 - "Nevertheless, according to currently available data, patients with hepatic presentation of Wilson disease are probably most effectively treated by D-penicillamine. " 12/01/1984 - "The best treatment for fulminant Wilson's disease is prevention by diagnosis in a pre-symptomatic stage and institution of carefully supervised life-long therapy with penicillamine." 04/12/1986 - "A patient who presented with severe hepatic Wilson's disease at age 14 responded well to treatment with penicillamine and remained in good health for a further 20 years, although she became somewhat careless about her medication towards the end of this period. " 06/28/1999 - "Treatment with penicillamine in Indian childhood disease, which probable has the same etiology, is effective when it is started early enough as well as in Wilson's disease. " 09/01/1993 - "D-penicillamine, an orally-administered chelating agent, is effective for Wilson's disease (WD). "
3.	Cystinuria 01/01/1993 - "Long-term D-penicillamine treatment can be used in patients with cystinuria and is both effective and safe. " 11/01/1981 - "We conclude that D-penicillamine is useful in the treatment of cystinuria. " 11/01/1981 - "A retrospective study was conducted to assess the efficacy of D-penicillamine in the management of cystinuria, as well as to define the frequency and nature of untoward reactions to this drug. " 12/01/2008 - "We reviewed the charts of all 11 children with cystinuria treated at our clinic using a gradual dose escalation of penicillamine. " 12/01/2008 - "We evaluated the effects of penicillamine in preventing stone formation and with respect to toxicity in our cystinuria cohort at a pediatric biochemical genetics clinic. "
4.	Arthritis (Polyarthritis) 03/01/1978 - "On the basis or a study of 50 cases of rheumatoid polyarthritis treated with D penicillamine comments are made on the failure of this form of treatment by comparison of the apparent and real efficacy. " 12/01/1977 - "[Study of optimal posology of penicillamine in the treatment of common rheumatoid polyarthritis (apropos of a personal series of 200 cases)]." 10/01/1972 - "[Study of various parameters of cellular and humoral immunity during the treatment of rheumatoid polyarthritis with D-penicillamine]." 02/01/1970 - "[Penicillamine and rheumatoid polyarthritis (study of 9 cases)]." 05/01/1991 - "D-penicillamine, on the other hand, showed no beneficial effects on arthritis except for inhibiting new bone formation. "
5.	Systemic Scleroderma (Systemic Sclerosis) 08/01/1985 - "These data suggest that D-penicillamine may be useful in the treatment of systemic sclerosis that involves the lung; however, further studies are needed." 06/01/2013 - "From a dermatologic standpoint, penicillamine was found to be useful in the treatment of systemic sclerosis. " 12/01/1999 - "[D-penicillamine: an outdated cure for systemic scleroderma?]." 06/01/2001 - "To compare the systemic sclerosis (SSc) patients entered into the d-penicillamine trial with SSc patients entered into previous controlled SSc trials. " 03/01/2001 - "The Disability Index of the Health Assessment Questionnaire is a predictor and correlate of outcome in the high-dose versus low-dose penicillamine in systemic sclerosis trial."

Related Drugs and Biologics

1.	Zinc
2.	Gold
3.	Copper
4.	Hydroxychloroquine (Plaquenil)
5.	Methotrexate (Mexate)
6.	Salts
7.	Trientine (Trien)
8.	Dimercaprol (B.A.L.)
9.	Sulfasalazine (Azulfidine)
10.	Azathioprine (Imuran)

Related Therapies and Procedures

1.	Chelation Therapy (Therapy, Chelation)
2.	Drug Therapy (Chemotherapy)
3.	Plasmapheresis
4.	Plasma Exchange
5.	Liver Transplantation