Pempidine

A nicotinic antagonist most commonly used as an experimental tool. It has been used as a ganglionic blocker in the treatment of hypertension but has largely been supplanted for that purpose by more specific drugs.

Also Known As:

Networked: 25 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Ganglion Cysts (Ganglion) 08/01/1974 - "Some of the compounds were tested for neuromuscular blocking activity on the rat diaphragm.4 Phenylbutyldiethylamine had ganglion-blocking activity greater than pempidine and little postganglionic blocking or neuromuscular blocking activity. " 11/28/1959 - "Congeners of pempidine with high ganglion-blocking activity." 09/01/1958 - "Pempidine (1:2:2:6:6-pentamethylpiperidine) is a long-acting ganglion-blocking compound which is effective by mouth. " 09/01/1958 - "Pharmacological properties of pempidine (1:2:2:6:6-pentamethylpiperidine), a new ganglion-blocking compound." 06/01/1964 - "Consistent with the view that ability to enter the fibre is important is the observation that mecamylamine and pempidine, which are ganglion-blocking agents, but not either mono- or bis-quaternary compounds, often abolish the response to stimulation of the sympathetic postganglionic fibre."
2.	Hypertension (High Blood Pressure) 07/15/1961 - "Pempidine in the treatment of hypertension." 01/07/1961 - "Pempidine for Hypertension." 09/12/1959 - "A clinical trial of pempidine in the treatment of hypertension." 03/01/1959 - "Pempidine and other drugs in the treatment of high blood pressure." 07/05/1958 - "Pharmacology and clinical use of pempidine in the treatment of hypertension."
3.	Cardiotoxicity 12/01/1958 - "Pempidine was about twice as active as mecamylamine on ganglia, but only about one half to one quarter as toxic as judged by death, growth, induction of tremor, or cardiotoxicity. "
4.	Mydriasis 09/01/1958 - "Pempidine is well absorbed from the gastro-intestinal tract as judged by (a) the low ratio (6.9) of oral to intravenous toxicities, (b) the rapid development of mydriasis in mice after oral administration of small doses, and (c) the rapid onset of hypotension when the compound is injected directly into the duodenum of anaesthetized cats. "
5.	Tremor (Tremors) 12/01/1958 - "Pempidine was about twice as active as mecamylamine on ganglia, but only about one half to one quarter as toxic as judged by death, growth, induction of tremor, or cardiotoxicity. "

Related Drugs and Biologics

1.	Mecamylamine
2.	Hexamethonium (Hexamethonium Bromide)
3.	Nicotine
4.	Reserpine (Serpasil)
5.	Pentolinium Tartrate (Pentolonium Tartrate)
6.	Luteolin
7.	Tetraethylammonium (Tetraethylammonium Bromide)
8.	Cetirizine (Zyrtec)
9.	Tubocurarine (Tubocurarine Chloride)
10.	Trimethaphan (Trimetaphan)

Related Therapies and Procedures

1.	Oral Administration
2.	Therapeutics
3.	Injections