Pelger-Huet Anomaly

An inherited defect interfering with normal nuclear lobulation of neutrophils and eosinophils. The nuclei appear rodlike, spherical, or dumbbell-shaped and their structure is coarse and lumpy. (From Dorland, 27th ed)

Also Known As:

Networked: 15 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Emery-Dreifuss Muscular Dystrophy (X-Linked Emery-Dreifuss Muscular Dystrophy)
2.	Polydactyly (Polydactylism)
3.	Thrombocytopenia (Thrombopenia)
4.	Seizures (Seizure)
5.	Pericardial Effusion

Experts

1.	Modaff, Peggy: 1 article (08/2013)
2.	Waterham, Hans R: 1 article (08/2013)
3.	Borovik, Lior: 1 article (08/2013)
4.	Krentz, Anthony D: 1 article (08/2013)
5.	Pauli, Richard M: 1 article (08/2013)
6.	Raina, Vinod: 1 article (07/2007)
7.	Kumar, Rajive: 1 article (07/2007)
8.	Anand, Mona: 1 article (07/2007)
9.	Bonne, Gisèle: 1 article (06/2007)
10.	Worman, Howard J: 1 article (06/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pelger-Huet Anomaly:

1.	Folic Acid (Vitamin M)FDA LinkGeneric 06/01/1987 - "The mechanism by which heat and folate deficiency induce neutrophil segmentation is preserved in the familial Pelger-Huet anomaly." 01/01/1990 - "The Pelger-Huet anomaly may be mistaken for an elevated band count, the macrocytic anemia appears not to be secondary to a vitamin B12 or folate deficiency, and the thrombocytopenia may be sensitive to drug dosage. " 01/01/1990 - "Four patients with severe cerebral palsy, mental retardation, and seizures who were treated with valproic acid showed a broad spectrum of hematologic toxicity, which included thrombocytopenia, macrocytic red cells with or without anemia, and the Pelger-Huet anomaly in the segmented neutrophils, along with elevated vitamin B12 levels, normal serum folic acid levels, and elevated fetal hemoglobin values (two cases). "
2.	ChromatinIBA 07/01/2007 - "Impaired lobulation of neutrophils together with exaggerated clumping of chromatin, characteristic of Pelger-Huet anomaly was seen as an incidentalfinding in a 43-year old man who presented with depression. " 01/01/2005 - "Lack of LBR protein in familial Pelger-Huet anomaly results in hypolobulation and chromatin-hypercondensation in neutrophils, but in other cells such as erythroblasts and lymphocytes only chromatin-hypercondensation can be observed. " 01/01/2005 - "We re-analyzed distribution of such Pelger-Huet anomaly in other cell lineages; we found that not only neutrophils but erythroblasts, monocytes, lymphocytes, plasma cells, eosinophils and basophils are also carrying chromatin-hypercondensation. " 01/01/2005 - "Especially in M3, differentiation-induction by all-trans retinoic acid induced a marked neutrophilia with pseudo-Pelger-Huet anomaly without chromatin-hypercondensation. "
3.	Alkaline PhosphataseIBA 04/01/1964 - "[ON THE ACTIVITY OF NEUTROPHILIC ALKALINE PHOSPHATASE WITH PELGER-HUET ANOMALY IN RABBITS]." 05/01/1980 - "Functional defects have also been identified in neutrophils with morphologic abnormalities, such as the Pelger-Huet anomaly and the May-Hegglin anomaly, and in neutrophils without alkaline phosphatase or with a disorder of the glutathione system. "
4.	Paclitaxel (Taxol)FDA LinkGeneric 04/01/1996 - "We describe the occurrence of acquired Pelger-Huet anomaly (APHA) in 23 patients treated with paclitaxel (13) or docetaxel (10). "
5.	Ganciclovir (Cytovene)FDA LinkGeneric 06/01/2002 - "Neutrophil dysplasia characterised by a pseudo-Pelger-Huet anomaly occurring with the use of mycophenolate mofetil and ganciclovir following renal transplantation: a report of five cases."
6.	Xylose (D-Xylose)FDA Link 02/01/1984 - "The Pelger-Huet anomaly was identified in dog 3. Maldigestion and malabsorption as determined by the N-benzoyl-L-tyrosyl-p-aminobenzoic acid and d-xylose test was documented to varying degrees in dogs with IPSID. "
7.	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 01/01/1990 - "The Pelger-Huet anomaly may be mistaken for an elevated band count, the macrocytic anemia appears not to be secondary to a vitamin B12 or folate deficiency, and the thrombocytopenia may be sensitive to drug dosage. " 01/01/1990 - "Four patients with severe cerebral palsy, mental retardation, and seizures who were treated with valproic acid showed a broad spectrum of hematologic toxicity, which included thrombocytopenia, macrocytic red cells with or without anemia, and the Pelger-Huet anomaly in the segmented neutrophils, along with elevated vitamin B12 levels, normal serum folic acid levels, and elevated fetal hemoglobin values (two cases). "
8.	Valproic Acid (Valproate, Semisodium)FDA LinkGeneric 01/01/1990 - "Four patients with severe cerebral palsy, mental retardation, and seizures who were treated with valproic acid showed a broad spectrum of hematologic toxicity, which included thrombocytopenia, macrocytic red cells with or without anemia, and the Pelger-Huet anomaly in the segmented neutrophils, along with elevated vitamin B12 levels, normal serum folic acid levels, and elevated fetal hemoglobin values (two cases). "
9.	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/01/2005 - "Especially in M3, differentiation-induction by all-trans retinoic acid induced a marked neutrophilia with pseudo-Pelger-Huet anomaly without chromatin-hypercondensation. "
10.	Proteins (Proteins, Gene)IBA 06/10/2007 - "Disorders caused by mutations in genes encoding lamin-associated integral inner nuclear membrane proteins include X-linked Emery-Dreifuss muscular dystrophy, sclerosing bone dysplasias, HEM/Greenberg skeletal dysplasia and Pelger-Huet anomaly. "

Therapies and Procedures

1.	Kidney Transplantation 06/01/2002 - "Neutrophil dysplasia characterised by a pseudo-Pelger-Huet anomaly occurring with the use of mycophenolate mofetil and ganciclovir following renal transplantation: a report of five cases."
2.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 09/01/1982 - "Transfer of Pelger-Huet anomaly by bone marrow transplantation."