Pedophilia

A sexual disorder occurring in a person 16 years or older and that is recurrent with intense sexually arousing fantasies, sexual urges, or behaviors involving sexual activity with a prepubescent child (generally age 13 or younger). (from APA, DSM-IV, 1994).

Also Known As:

Networked: 60 relevant articles (2 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Paraphilic Disorders (Paraphilia)
2.	Exhibitionism
3.	Voyeurism
4.	Virilism (Virilization)
5.	Antisocial Personality Disorder (Antisocial Personality)

Experts

1.	Walter, Henrik: 5 articles (11/2021 - 05/2014)
2.	Beier, Klaus M: 4 articles (11/2021 - 01/2015)
3.	Ponseti, Jorge: 4 articles (11/2021 - 01/2015)
4.	Schiffer, Boris: 4 articles (11/2021 - 01/2015)
5.	Walter, Martin: 4 articles (11/2021 - 01/2015)
6.	Briken, Peer: 4 articles (01/2018 - 08/2003)
7.	Frieling, Helge: 3 articles (11/2021 - 01/2015)
8.	Kneer, Jonas: 3 articles (11/2021 - 01/2017)
9.	Kruger, Tillmann H C: 3 articles (11/2021 - 01/2015)
10.	Tenbergen, Gilian: 3 articles (01/2019 - 01/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pedophilia:

1.	Gonadotropin-Releasing Hormone (GnRH)FDA Link 01/01/2012 - "LH-RH agonists modulate amygdala response to visual sexual stimulation: a single case fMRI study in pedophilia." 05/17/2014 - "Changed processing of visual sexual stimuli under GnRH-therapy--a single case study in pedophilia using eye tracking and fMRI." 02/01/2012 - "A pilot study of the effects of gonadotropin-releasing hormone agonist therapy on brain activation pattern in a man with pedophilia." 01/01/2001 - "Up to now there have been no published results of therapy of paraphilia (for example, pedophilia or sadism) and sexual aggressive impulsiveness with luteinizing hormone-releasing hormone (LHRH) agonists in the German-speaking countries. " 05/01/2000 - "Up to now there are no published results of therapy of paraphilia (Pedophilia, Sadism) and sexual aggressive impulsiveness with LHRH-(luteinizing hormone-releasing hormone) Agonists in the Germanspeaking countries. "
2.	2- benzylidene- 3- (cyclohexylamino)- 2,3- dihydro- 1H- inden- 1- oneIBA 01/01/2011 - "This chapter proposes a prospective view on using a real-time functional magnetic imaging (rt-fMRI) brain-computer interface (BCI) application as a new treatment for pedophilia. "
3.	Triptorelin Pamoate (Trelstar)FDA Link 01/01/2012 - "In this multicenter, forensic psychiatric hospital-based, double-blind, controlled, parallel group phase IV trial conducted in Germany, convicted male sexual offenders aged ≥ 18 years with pedophilia, as defined by DSM-IV-TR criteria, will be randomized to receive study-specific psychotherapy together either with triptorelin or placebo for 12 months (total of 4 injections). " 01/01/2012 - "The aim of this pilot study is to evaluate the efficacy and tolerability of cognitive-behavioral psychotherapy together with intramuscular (IM) 3-monthly injections of triptorelin in adult men with severe pedophilia. " 01/01/2012 - "This survey was part of a larger scale research on the effectiveness of Decapeptyl injections as treatment for pedophilia. " 02/12/1998 - "In an uncontrolled observational study, we treated 30 men (mean age, 32 years) with severe long-standing paraphilia (25 with pedophilia and 5 with other types of abnormal behavior) with monthly injections of 3.75 mg of triptorelin and supportive psychotherapy for 8 to 42 months. "
4.	Indicators and Reagents (Reagents)IBA 08/01/2006 - "This study investigated whether being charged with a child pornography offense is a valid diagnostic indicator of pedophilia, as represented by an index of phallometrically assessed sexual arousal to children. " 10/01/2017 - "Recent research suggests that child pornography offending is a valid and perhaps independent indicator of pedophilia. " 08/01/2006 - "The results suggest child pornography offending is a stronger diagnostic indicator of pedophilia than is sexually offending against child victims. " 08/01/2006 - "Child pornography offenses are a valid diagnostic indicator of pedophilia." 01/01/1990 - "All too often research is unreliable because (1) it assumes pedosexual activity is a positive indicator of pedophilia; (2) no distinction is drawn between pseudo-pedophiles and real pedophiles; (3) no difference is recognized between boys and girls as partners; and (4) it is highly distorted by bias. "
5.	Hormones (Hormone)IBA 01/01/1997 - "[Hormone treatment of pedophilia]." 01/01/2019 - "This study assessed markers of prenatal brain androgenization, genetic parameters of androgen receptor function, epigenetic regulation, and peripheral hormones in a 2 × 2 factorial design comprising the factors Offense (yes/no) and Pedophilia (yes/no) in analyzing blood samples from 194 subjects (57 P+CSO, 45 P-CSO, 20 CSO-P, and 72 controls) matched for age and intelligence. "
6.	Androgen Receptors (Androgen Receptor)IBA 01/01/2019 - "This study assessed markers of prenatal brain androgenization, genetic parameters of androgen receptor function, epigenetic regulation, and peripheral hormones in a 2 × 2 factorial design comprising the factors Offense (yes/no) and Pedophilia (yes/no) in analyzing blood samples from 194 subjects (57 P+CSO, 45 P-CSO, 20 CSO-P, and 72 controls) matched for age and intelligence. "
7.	Phospholipids (Phosphatides)FDA LinkGeneric 12/01/2006 - "This study examines the serum phospholipid n-3 and n-6 PUFA fractions in pedophilia. " 12/01/2006 - "The results of this study suggest that a depletion of the serum phospholipid n-3 higher unsaturated fatty acids (HUFAs) and, in particular, of DHA may take part in the pathophysiology of pedophilia. "
8.	Nimodipine (Modus)FDA LinkGeneric 10/01/2021 - "This study suggests that idiopathic and acquired pedophilia may be two distinct disorders, in line with their distinctive clinical features, including age of onset, reversibility and modus operandi. "
9.	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 12/01/2006 - "Depletion of n-3 polyunsaturated fatty acids (PUFA) may cause alterations in the serotonergic system that may be related to pedophilia and aggression. " 12/01/2006 - "The results of this study suggest that a depletion of the serum phospholipid n-3 higher unsaturated fatty acids (HUFAs) and, in particular, of DHA may take part in the pathophysiology of pedophilia. " 12/01/2006 - "Lower omega-3 polyunsaturated fatty acids and lower docosahexaenoic acid in men with pedophilia."
10.	4-aminospiroperidolIBA 12/01/2016 - "The purpose of this study was to examine (a) whether individuals with paraphilia diagnoses have cognitive deficits compared with the general population; (b) whether individuals diagnosed with pedophilia differed on cognitive performance when compared with individuals diagnosed with paraphilia not otherwise specified (NOS), nonconsent; and (c) whether individuals with paraphilia plus antisocial personality disorder (ASPD) differed in cognitive performance when compared with individuals with a paraphilia diagnosis only. "

Therapies and Procedures

1.	Therapeutics 05/01/2016 - "[Prevention of pedophilia: therapy for more than 500 men]." 09/01/2013 - "[Pedophilia: etiology, diagnostics and therapy]." 03/01/2012 - "Consequently, pedophilia is not only relevant in psychiatric therapy and prognostics, but also greatly influences the public attitude towards criminality. " 10/01/1978 - ""Biosyntonic" therapy: modification of an operant conditioning approach to pedophilia." 01/01/1997 - "Pedophilia is only one of the sexual deviations that can be treated by chemical castration and it is presently unclear whether pedophilia responds better or worse to this therapy in sexual offenders. "
2.	Brain-Computer Interfaces 01/01/2011 - "Real-time functional magnetic imaging-brain-computer interface and virtual reality promising tools for the treatment of pedophilia." 01/01/2011 - "This chapter proposes a prospective view on using a real-time functional magnetic imaging (rt-fMRI) brain-computer interface (BCI) application as a new treatment for pedophilia. "
3.	Injections 01/01/2012 - "In this multicenter, forensic psychiatric hospital-based, double-blind, controlled, parallel group phase IV trial conducted in Germany, convicted male sexual offenders aged ≥ 18 years with pedophilia, as defined by DSM-IV-TR criteria, will be randomized to receive study-specific psychotherapy together either with triptorelin or placebo for 12 months (total of 4 injections). " 01/01/2012 - "The aim of this pilot study is to evaluate the efficacy and tolerability of cognitive-behavioral psychotherapy together with intramuscular (IM) 3-monthly injections of triptorelin in adult men with severe pedophilia. " 01/01/2012 - "This survey was part of a larger scale research on the effectiveness of Decapeptyl injections as treatment for pedophilia. " 02/12/1998 - "In an uncontrolled observational study, we treated 30 men (mean age, 32 years) with severe long-standing paraphilia (25 with pedophilia and 5 with other types of abnormal behavior) with monthly injections of 3.75 mg of triptorelin and supportive psychotherapy for 8 to 42 months. "
4.	Secondary Prevention 01/01/2019 - "We argue that engaging in secondary prevention programs for people with pedophilia, in order to prevent child sexual abuse, is an ethically responsible and necessary practice. " 01/01/2019 - "Bioethical Issues and Secondary Prevention for Nonoffending Individuals with Pedophilia." 09/01/2013 - "According to the current state of knowledge cognitive-behavioral psychotherapy is the method of choice in the treatment of pedophilia and has demonstrated positive treatment effects in meta-analyses regarding relapse prevention. " 01/01/2006 - "Secondly, the typical CBT-based relapse prevention treatment for pedophilia, which represents current best practice, is reviewed. "
5.	Castration 09/30/2015 - "Current opinions on chemical castration for pedophilia are discordant. " 01/07/1996 - "[Chemical castration in homosexual pedophilia]." 01/01/1997 - "Pedophilia is only one of the sexual deviations that can be treated by chemical castration and it is presently unclear whether pedophilia responds better or worse to this therapy in sexual offenders. " 09/30/2015 - "Androgen deprivation therapy (castration therapy) and pedophilia: What's new."