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Paromomycin (Paromomycin Sulfate)

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An oligosaccharide antibiotic produced by various STREPTOMYCES.

Also Known As:

Paromomycin Sulfate; Humatin; Cheminova Brand of Paromomycin Sulfate; Gabbromycin; Monarch Brand of Paromomycin Sulfate; Paramomycin; Parke Davis Brand of Paromomycin Sulfate; Paromomycin I; Paromomycin Phosphate; Paromomycin Sulfate (1:1); Paromomycin Sulfate (2:5); Paromomycin, beta-D-Glucopyranosyl-Isomer; Pfizer Brand of Paromomycin Sulfate; Paromomycin, beta D Glucopyranosyl Isomer; Phosphate, Paromomycin; Sulfate, Paromomycin; beta-D-Glucopyranosyl-Isomer Paromomycin; Aminosidine; Catenulin; Estomycin; Hydroxymycin; Neomycin E; D-Streptamine, O-2-amino-2-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1-3)-beta-D-ribofuranosyl-(1-5))-2-deoxy-

Networked: 394 relevant articles (69 outcomes, 68 trials/studies)

Relationship Network

Drug Context: Research Results

Carbohydrates: 4088
- Glycosides: 547
  - Aminoglycosides: 1446
    - Neomycin: 1160
      - Paromomycin: 394
        lividomycins: 23
        3',4'-dideoxyparomomycin
        3-N-methylparomomycin I
        6'''-deamino-6'''-hydroxyparomomycin I
        dansylparomomycin
        deneosaminyllividomycins
        NB33 compound
        ribosylparomamine

Experts

1.	Sundar, Shyam: 7 articles (03/2012 - 06/2007)
2.	Ferreira, Lucas Antônio Miranda: 4 articles (12/2015 - 02/2005)
3.	Das, Pradeep: 4 articles (03/2014 - 04/2011)
4.	Olliaro, P: 4 articles (10/2011 - 07/2000)
5.	Fernandes, Ana Paula: 4 articles (11/2010 - 02/2005)
6.	Aguiar, Marta Gontijo: 3 articles (12/2015 - 12/2009)
7.	Rijal, Suman: 3 articles (01/2015 - 04/2011)
8.	Arrowood, Michael J: 3 articles (01/2015 - 06/2009)
9.	Bavarsad, Neda: 3 articles (11/2014 - 06/2009)
10.	Pandey, Krishna: 3 articles (03/2014 - 10/2011)

Related Diseases

1.	Cutaneous Leishmaniasis 01/01/2009 - "Is paromomycin an effective and safe treatment against cutaneous leishmaniasis? " 01/01/2005 - "Efficacy of paromomycin ointment in the treatment of cutaneous leishmaniasis: results of a double-blind, randomized trial in Isfahan, Iran." 08/01/1995 - "A randomized, placebo-controlled, double-blind trial was carried out in 1992 in central Tunisia to assess the tolerability and efficacy of paromomycin ointment against zoonotic cutaneous leishmaniasis caused by Leishmania major. " 01/01/2003 - "Although about half of those cured might have recovered spontaneously even without treatment, four weeks of aminosidine ointment could become the first-line treatment for uncomplicated cutaneous leishmaniasis due to L. " 10/01/2012 - "The aim of this study was to develop transfersomal formulation with respect to dermal delivery of paromomycin sulfate (PM) for possible topical therapy of cutaneous leishmaniasis (CL). "
2.	Cryptosporidiosis 02/01/2002 - "At the recommended levels, paromomycin reduced the oocyst output of birds by 67-82%, showing the highest efficacy of all drugs tested against avian cryptosporidiosis thus far. " 06/27/2000 - "The objective of this study was to evaluate the therapeutic efficacy of paromomycin against cryptosporidiosis in naturally infected lambs under field conditions. " 02/01/1993 - "Recent reports suggest that paromomycin may be useful in the treatment of intestinal cryptosporidiosis. " 11/16/2002 - "A prospective, controlled-blind field trial was conducted to evaluate the efficacy and safety of paromomycin sulphate, given for 10 days from birth, in preventing natural cryptosporidiosis in calves. " 08/01/1994 - "The present study aimed at investigating the efficiency of a recent antibiotic Aminosidine sulphate (Gabbroral) in experimental cryptosporidiosis. "
3.	Infection 02/01/1997 - "Paromomycin therapy was associated with a complete resolution of diarrhoea in 60% of patients treated and some improvement in symptoms in a further 5% but it did not eliminate the infection. " 07/01/1994 - "Paromomycin treatment was very effective against villus surface infections in suckling mice and considerably less effective against infections in inaccessible sites such as abscessed crypts and stomach pits seen in weaned and adult scid mice. " 01/26/2015 - "fragilis infection was thereafter treated successfully with paromomycin. " 12/01/1975 - "Some in vivo experiments of therapeutic activity in severe experimental infection (intracranial) in the mouse due to different strains of Mycoplasma proved the high efficacy of the antibiotic aminosidine when administered subcutaneously at the dose of 30 mg/kg and have also demonstrated that oral treatment is moderately effective against Mycoplasma hominis 2. Sensitivity test carried out in vitro on the same Mycoplasma strains confirmed the bactericidal activity of aminosidine. " 06/27/2000 - "Field trial on the therapeutic efficacy of paromomycin on natural Cryptosporidium parvum infections in lambs."
4.	Acquired Immunodeficiency Syndrome (AIDS) 03/01/1997 - "Treatment with paromomycin and antimotility agents was effective in reducing diarrheal symptoms in 54 of 70 (77%) patients with the acquired immunodeficiency syndrome (AIDS), although there was a high rate of relapse. " 09/01/1994 - "The MICs and MBCs of paromomycin for 32 Mycobacterium avium complex (MAC) strains isolated from patients with the acquired immunodeficiency syndrome were determined by a radiometric broth dilution method. " 12/01/1993 - "Paromomycin is the most effective agent available to date for the treatment of this devastating complication of AIDS." 09/01/1991 - "Paromomycin for the treatment of cryptosporidial diarrhoea in AIDS patients." 11/01/2013 - "Polymerase chain reaction/restriction fragment length polymorphism of the 18 S rRNA gene and sequencing were performed on 41 Cryptosporidium-positive stools from 36 patients with HIV AIDS, which comprised 36 pretreatment stools and 5 stools after treatment with Paromomycin. "
5.	Visceral Leishmaniasis (Kala Azar) 01/01/2015 - "Though the impact of these findings should be further explored, the study results suggest that the epidemiological implications of acquired paromomycin-resistance may remain minimal other than the loss of one of the last remaining drugs effective against visceral leishmaniasis. " 12/01/1998 - "Comparison of the efficacy of free and non-ionic-surfactant vesicular formulations of paromomycin in a murine model of visceral leishmaniasis." 04/18/1998 - "A 21 day course of aminosidine 16 or 20 mg/kg/day should be considered as first line treatment for visceral leishmaniasis in Bihar." 10/01/2015 - "Effectiveness Study of Paromomycin IM Injection (PMIM) for the Treatment of Visceral Leishmaniasis (VL) in Bangladesh." 01/01/2011 - "Phase 4 pharmacovigilance trial of paromomycin injection for the treatment of visceral leishmaniasis in India."

Related Drugs and Biologics

1.	miltefosine
2.	Azithromycin (Zithromax)
3.	Paromomycin (Paromomycin Sulfate)
4.	methylbenzethonium (Bactine)
5.	meglumine antimoniate
6.	Antimony Sodium Gluconate (Sodium, Stibogluconate)
7.	Amphotericin B (Amphotericin)
8.	nitazoxanide (NTZ)
9.	Antimony
10.	Meglumine

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Photochemotherapy (Photodynamic Therapy)
3.	Highly Active Antiretroviral Therapy (HAART)
4.	Injections
5.	Cryotherapy (Therapy, Cold)