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Paresthesia (Dysesthesia)

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Subjective cutaneous sensations (e.g., cold, warmth, tingling, pressure, etc.) that are experienced spontaneously in the absence of stimulation.

Also Known As:

Dysesthesia; Paresthesias; Formication; Paresthesia, Distal; Paresthesia, Painful; Distal Paresthesia; Distal Paresthesias; Dysesthesias; Formications; Painful Paresthesia; Painful Paresthesias; Paresthesias, Distal; Paresthesias, Painful

Networked: 1381 relevant articles (88 outcomes, 70 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Hypesthesia (Numbness)
3.	Headache (Headaches)
4.	Paresthesia (Dysesthesia)
5.	Hyperalgesia

Experts

1.	Hulihan, Joseph: 7 articles (01/2011 - 06/2003)
2.	Rosenthal, Norman R: 5 articles (05/2007 - 02/2003)
3.	LaMotte, Robert H: 4 articles (08/2015 - 07/2009)
4.	North, Richard B: 4 articles (10/2012 - 08/2002)
5.	Kira, Jun-ichi: 4 articles (06/2011 - 11/2003)
6.	Haas, Daniel A: 4 articles (10/2010 - 01/2006)
7.	Wiegand, Frank: 4 articles (08/2009 - 02/2005)
8.	Capece, Julie A: 4 articles (06/2008 - 06/2005)
9.	Brown, Mark T: 3 articles (11/2014 - 10/2010)
10.	Wolter, Tilman: 3 articles (11/2013 - 05/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Paresthesia:

1.	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 07/01/1949 - "The paresthesias associated with combined system disease as well as disturbances in position sense and locomotor function may be entirely relieved or greatly diminished following injections of vitamin B(12). " 06/01/2013 - "We diagnosed him with subacute combined degeneration on the evidence of history of gastrectomy, lower normal limit of vitamin B12 (363 pg/ml), apparent absence of vibration sensations and paresthesia in the feet. " 01/01/1995 - "Subacute combined degeneration of the spinal cord (vitamin B12-deficient myelopathy) is a neurologic disorder manifesting progressive symptoms of paresthesia and spastic paralysis. " 01/01/2009 - "In this randomized, single-blind clinical trial we compared the efficacy of parenteral vitamin B(12) and nortriptyline, for symptomatic improvement of pain, paresthesia, burning, freezing, stabbing and electrical sensation. " 06/01/2005 - "Both the vitamin B12 combination and pure methylcobalamin had beneficial effects on somatic symptoms, such as pain and paresthesia. "
2.	Prednisolone (Predate)FDA LinkGeneric 02/01/2001 - "The treatment with prednisolone (60 mg/day) improved the pain but the dysesthesia continued. " 10/01/2007 - "Steroid pulse and oral prednisolone treatment resulted in ameriolation of cerebral complications such as disorientation and convulsion, but muscle weakness and paresthesia in the lower limbs and urinary retention persisted. " 02/01/2013 - "The patient was started on prednisolone in addition to the entecavir, and showed significant improvement in motor power and marked resolution in paresthesia after 2 weeks of treatment. " 01/01/2011 - "After methylprednisolone pulse therapy followed by oral administration of prednisolone, visual dysfunction, dysuria, limb dysesthesia and hyperreflexia were improved. "
3.	topiramate (Topamax)FDA LinkGeneric 07/01/2012 - "This study was done to find out the role of topiramate therapy in infraorbital nerve paresthesia after miniplate fixation in zygomatic complxex fractures. " 03/01/2008 - "Paresthesia was the most common topiramate-associated AE (35%, 51%, and 49% of patients receiving topiramate 50 mg/day, 100 mg/day, or 200 mg/day, respectively [6% on placebo]). " 09/01/2007 - "Relative to adjunctive placebo, topiramate-treated patients experienced higher rates of paresthesia, sedation, word-finding difficulty, sleepiness, and forgetfulness, but these differences were not statistically significant. " 11/01/2004 - "The most common adverse events more frequently observed in topiramate-treated subjects occurred mostly during the titration phase and were related to the central or peripheral nervous system and included paresthesia, difficulty with concentration/attention, depression, difficulty with memory, language problems, nervousness, and psychomotor slowing. " 06/01/2003 - "Paresthesia was the most common side effect reported with topiramate treatment. "
4.	Lidocaine (Xylocaine)FDA LinkGeneric 02/01/2014 - "The incidence of paresthesia in 2% lidocaine gel group was significantly higher than those of the other two groups immediately after operation, but it was resolved after leaving the recovery room. " 05/01/2010 - "Ultrasound-guided injection of 0.5% lidocaine temporarily resolved the paresthesia. " 10/01/1998 - "Patients in the deep block group who reported paresthesia during block placement required less lidocaine supplementation (median, 2; range, 0.5 to 20 ml) than the 9.5 ml (range, 6 to 15.5 ml) required by those who did not experience paresthesia (P = 0.0113). " 10/01/1998 - "Outcomes subjected to statistical analysis included supplemental anesthetic supplementation with lidocaine, 1%, by the surgeon, dermatomes affected by the block, paresthesia during block placement, postoperative pain scores, and analgesic requirements. " 04/01/2002 - "A diagnostic stellate ganglion block (SGB) 45 days after the tooth extraction using one percent lidocaine markedly alleviated the dysesthesia and allodynia. "
5.	Carticaine (Articaine)IBA 01/01/2013 - "The results suggest that articaine is not toxic to the nervous structure and further studies are necessary to explain the possible relation between articaine injection and paresthesia." 01/01/2009 - "The 'question' about an increased risk of paresthesia following articaine administration via IANB has been answered by careful evaluation of case reports. " 12/01/2006 - "Despite an increase in anecdotal reports of paresthesia since articaine's introduction there is yet, no supporting scientific evidence." 01/01/2006 - "This article reviews the epidemiological evidence regarding articaine and paresthesia." 01/01/2006 - "Articaine and paresthesia: epidemiological studies."
6.	gabapentin (Neurontin)FDA LinkGeneric 12/01/2008 - "This dysesthesia was improved by the use of gabapentin." 10/01/2000 - "Decreases in paresthesia scores also were in favor of gabapentin (1.8 vs. 0.9 points; P = 0. " 07/15/2012 - "Post-radiosurgery numbness/paresthesias correlated with the use of gabapentin (1 of 36 patients with gabapentin vs. 7 of 28 without, p = 0.017). " 10/01/2009 - "In gabapentin group, mean pain and paresthesia scores regressed from 2.12+/- 0.76 to 0.54+/- 0.83 (p<0.001) and from 1.72+/- 0.74 to 0.49+/- 0.62 (p<0.001), respectively. " 04/01/2012 - "Reported adverse events included somnolence with gabapentin and paresthesias with acetazolamide. "
7.	Glutamine (L-Glutamine)FDA Link 05/01/2001 - "For patients who received glutamine, there was a statistically significant reduction in the severity of peripheral neuropathy as measured by development of moderate to severe dysesthesias and numbness in the fingers and toes (P < 0.05). " 10/01/2008 - "Two studies revealed that oral glutamine was effective in reducing peripheral neuropathy associated with high-dose paclitaxel, as evidenced by a reduction in numbness, dysesthesias, and motor weakness, as well as a smaller loss of vibratory sensation. "
8.	Calcium DobesilateIBA 03/01/2004 - "Calcium dobesilate improved paresthesias significantly more than placebo in the severe but not in the mild group and the effect on leg volume was also significantly better in the severe group (-7.2% vs -1.6%). " 04/01/1990 - "The results show that at the end of the trial, all the examined parameters (leg oedema, pain, day and night cramps, discomfort, heavy legs, paresthesia and restless legs) were significantly more improved in the Doxium group than in the placebo group: the leg volume was diminished by 3.8% in the Doxium group compared to 1.2% in the placebo (p less than 0.005). "
9.	CalciumIBA 10/01/2003 - "Ingestion of 2 g of oral Ca resulted in a significant reduction in the severity of paresthesias and a significant, though modest, increase in serum ionized calcium (iCa), but no significant improvement in total symptom scores, compared to placebo. " 12/01/2002 - "The outcome measures were postoperative serum calcium and the presence of signs or symptoms such as paresthesias, anxiety, or Chvostek's sign. " 10/01/2001 - "Most of them were paresthesias, which could be easily treated by calcium supplementation. " 10/01/2001 - "Paresthesias were treated by oral (20.4%) or intravenous (1.1%) calcium supplementation. " 06/01/1983 - "The serum calcium gradually fell to 7.0 mg/dl on the 45th hospital day when the serum total protein was 6.8 g/dl and she complained of paresthesia in the extremities. "
10.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 10/01/2007 - "Cyclophosphamide pulse therapy was started and resulted in a marked recovery from muscle weakness, paresthesia and urinary retention, and she could discharge. " 10/01/2007 - "We conclude that steroid and cyclophosphamide pulse therapy for a SLE patient with CNS lupus and lupus myelitisis is effective for ameriolation of symptoms such as disorientation, convulsion, urinary retension, fecal incontinence, muscle weakness and paresthesia in the lower limbs as well as elevated level of serum anti-ribosomal P antibody." 08/01/2010 - "Intravenous cyclophosphamide with oral tacrolimus effectively improved dysesthesia with reduction of inflammatory response." 04/01/2007 - "After the fifth cycle of chemotherapy (FCR: fludarabine, cyclophosphamide, rituximab and prednisone) the 63-year-old patient developed night sweat, arthralgia in elbows, wrists, proximal interphalangeal joints (PIPs) and strong neuropathic pain in both legs, followed by paresthesia and hypesthesia in the feet, arms and face. "

Therapies and Procedures

1.	Electrodes (Electrode) 12/01/2009 - "When the paresthesia area can be covered with several configurations, it will be beneficial for the patient to program a configuration with 1 cathode and either no or multiple anodes." 04/01/2010 - "Furthermore, therapeutic efficacy of ONS is directly related to the ability of the stimulating electrode to produce peripheral nerve dermatomal paresthesia, emphasizing the need for precision placement. " 08/01/2012 - "The aim of this computational study was to (1) investigate the neuronal pathways modulated by therapeutic, sub-therapeutic and paresthesia-inducing DBS settings in three patients with ET and (2) determine how much better an outcome could have been achieved had these patients been implanted with a DBS lead containing directionally segmented electrodes (dDBS). " 01/01/1999 - "Detailed mapping studies are needed to evaluate the relationship between electrode placement and paresthesia patterns as well as the optimal stimulation parameters." 06/01/2014 - " Fluctuations in paresthesia perception are largely caused by variation in the distance between the fixed electrodes and the spinal cord consequent to patient movement. "
2.	Aftercare (After-Treatment) 06/01/2015 - "After treatment with axillary dissection with radiation therapy to the SCLNs 20% of the women reported paresthesia, compared with 13% after axillary dissection without radiation therapy, resulting in a relative risk (RR) of 1.47 (95% confidence interval [CI] 1.02-2.11). " 11/16/2001 - "The exam performed after treatment revealed a partial recovery of lower limb SEP with presence of an evoked response in SEP of left lower limb, coincident with a transitory clinical improvement of paresthesia in the same extremity. " 10/01/1989 - "One year after treatment, the patient developed paresthesias in the ipsilateral arm. " 12/01/1999 - "Paresthesia was reported by 83% of the patients immediately after treatment, 50% at follow-up 4-9 years after chemotherapy and 14% prevalence 11-15 hears after treatment. " 09/01/2007 - "Paresthesia improved, and follow-up brain MR imaging showed the decreased size and numbers of ring-enhanced lesions and improvement of perilesional edema 1 month after treatment. "
3.	Drug Therapy (Chemotherapy) 11/01/1995 - "After adequate chemotherapy ocular symptoms and dysesthesia improved rapidly. " 05/01/2011 - "However, adverse effects such as cold-sensitive paresthesia and bone marrow suppression are common, and this may necessitate a change of chemotherapy regimen even though FOLFOX is effective. " 08/01/2009 - "The most commonly observed scenario is paraesthesia and dysesthesia as a result of toxic effects of chemotherapies on the distal peripheral nerves. " 03/01/2008 - "Progressive paresthesia and weakness after intrathecal chemotherapy." 01/01/2003 - "Paresthesia grade 1 or 2 was observed in 18 of 19 patients of group A and in 8 of 19 patients of group B, following the sixth cycle of chemotherapy (p = 0.018). "
4.	Plasma Exchange 06/01/1997 - "We describe a 69-year-old female with Guillain-Barré syndrome (GBS) whose paresthesia and weakness improved after plasma exchange (PE) and intravenous high-dose immune globulin (i.v.I.G.). " 04/01/2004 - "In this study plasma exchange treatment resulted 6 days later in improvement in extremity weakness and paresthesias in the upper and lower extremities. " 12/15/2008 - "Intravenous immunoglobulin therapy and plasma exchange ameliorated his dysesthesia and dysphagia after several weeks, and resulted in improvements in VF and SNAP abnormalities. "
5.	Injections 09/01/2000 - "Facial paresthesias in patients who have received prior retrobulbar alcohol injections are not relieved by enucleation." 07/01/2015 - "The percentage of those experiencing paresthesia after the microfat injections also gradually diminished to none. " 01/01/2012 - "When using the blunt needles, vascular penetration and paresthesia were less during transforaminal epidural steroid injections. " 10/01/2009 - "During 2006-2008 alone, 64 cases of nonsurgical paresthesia were reported to PLP, a reported incidence of 1 in 609,000 injections. " 11/01/2006 - "As prevention from intraneural injections today are in use two methods: the method of causing paresthesia or the method of using the peripheral nerve stimulator. "