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Paratuberculosis (Johne's Disease)

A chronic GASTROENTERITIS in RUMINANTS caused by MYCOBACTERIUM AVIUM SUBSPECIES PARATUBERCULOSIS.
Also Known As:
Johne's Disease; Johne Disease; Disease, Johne; Disease, Johne's; Johnes Disease; Paratuberculoses
Networked: 1255 relevant articles (46 outcomes, 130 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Paratuberculosis (Johne's Disease)
2. Infections
3. Crohn Disease (Crohn's Disease)
4. Tuberculosis (Tuberculoses)
5. Bovine Tuberculosis

Experts

1. Bannantine, John P: 68 articles (03/2022 - 09/2001)
2. Stabel, Judith R: 34 articles (03/2022 - 09/2001)
3. Stabel, J R: 32 articles (01/2021 - 06/2000)
4. Whittington, Richard J: 29 articles (01/2021 - 12/2004)
5. Collins, Michael T: 23 articles (12/2010 - 07/2002)
6. Kapur, Vivek: 22 articles (03/2022 - 04/2002)
7. Talaat, Adel M: 17 articles (01/2021 - 06/2007)
8. Sreevatsan, Srinand: 17 articles (01/2020 - 12/2003)
9. Begg, Douglas J: 17 articles (07/2019 - 07/2008)
10. Sechi, Leonardo A: 16 articles (10/2022 - 03/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Paratuberculosis:
1. VaccinesIBA
2. AntigensIBA
3. AgarIBA
4. Inactivated VaccinesIBA
5. Proteins (Proteins, Gene)FDA Link
6. EnzymesIBA
7. Complement System Proteins (Complement)IBA
8. ImmunosorbentsIBA
9. Interferon-gamma (Interferon, gamma)IBA
10. Tuberculin (PPD)IBA

Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Euthanasia (Mercy Killing)
05/01/2010 - "paratuberculosis under in vitro culture conditions, has therapeutic value as a probiotic for adult cattle with paratuberculosis.  Animals were obtained from several herds with evidence of disease based on seropositivity and/or fecal shedding.  Sixty-eight cows with initial evidence of Stage II or III paratuberculosis and 2 with an initial Stage IV disease were evaluated longitudinally.  Animals were either treated daily with variable, disease-dependent doses of Dietzia (n = 48) or left untreated (n = 22).  Clinical aspects of disease (diarrhea, emaciated, cachectic and appetite) were recorded until the animal recovered or required euthanasia due to advanced clinical paratuberculosis or other severe conditions.  Paratuberculosis parameters-antibody serology (ELISA, AGID) and fecal culture-were longitudinally monitored over the lifetime of each animal.  The results indicated that daily treatment with Dietzia was therapeutic for paratuberculosis cows based on: (a) longitudinal decline in ELISA values only occurred in animals that were treated; (b) prolonged survival was dependant upon treatment--the length being directly associated with low initial ELISA values; and (c) treated animals were the only ones cured of disease.  Further investigations are envisaged to determine optimal, long-term dosages that may result in even better therapeutic outcomes as well as to evaluate potential application for therapy of the Johne's disease, human-counterpart, Crohn's disease."
4. Oral Administration
5. Lasers (Laser)