Paratuberculosis (Johne's Disease)

Also Known As:
Johne's Disease; Johne Disease; Disease, Johne; Disease, Johne's; Johnes Disease; Paratuberculoses
Networked: 786 relevant articles (21 outcomes, 53 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Paratuberculosis (Johne's Disease)
2. Crohn Disease (Crohn's Disease)
3. Infection
4. Tuberculosis (Tuberculoses)
5. Bovine Tuberculosis


1. Bannantine, John P: 38 articles (09/2015 - 04/2002)
2. Stabel, J R: 27 articles (08/2013 - 06/2000)
3. Stabel, Judith R: 23 articles (09/2015 - 05/2002)
4. Whittington, Richard J: 21 articles (06/2014 - 01/2007)
5. Collins, Michael T: 18 articles (12/2010 - 07/2002)
6. Kapur, Vivek: 14 articles (01/2014 - 04/2002)
7. Begg, Douglas J: 12 articles (06/2014 - 07/2008)
8. Paustian, Michael L: 12 articles (11/2009 - 01/2004)
9. Stevenson, Karen: 11 articles (01/2015 - 11/2002)
10. Coussens, Paul M: 11 articles (01/2014 - 10/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Paratuberculosis:
1. AntigensIBA
2. AgarIBA
3. VaccinesIBA
4. Complement System Proteins (Complement)IBA
5. Interferon-gamma (Interferon, gamma)IBA
6. Immunoglobulin G (IgG)IBA
7. Proteins (Proteins, Gene)IBA
8. Tuberculin (PPD)IBA
9. lipoarabinomannan (LAM)IBA
10. Monensin (Coban)IBA

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Euthanasia (Mercy Killing)
05/01/2010 - "paratuberculosis under in vitro culture conditions, has therapeutic value as a probiotic for adult cattle with paratuberculosis.  Animals were obtained from several herds with evidence of disease based on seropositivity and/or fecal shedding.  Sixty-eight cows with initial evidence of Stage II or III paratuberculosis and 2 with an initial Stage IV disease were evaluated longitudinally.  Animals were either treated daily with variable, disease-dependent doses of Dietzia (n = 48) or left untreated (n = 22).  Clinical aspects of disease (diarrhea, emaciated, cachectic and appetite) were recorded until the animal recovered or required euthanasia due to advanced clinical paratuberculosis or other severe conditions.  Paratuberculosis parameters-antibody serology (ELISA, AGID) and fecal culture-were longitudinally monitored over the lifetime of each animal.  The results indicated that daily treatment with Dietzia was therapeutic for paratuberculosis cows based on: (a) longitudinal decline in ELISA values only occurred in animals that were treated; (b) prolonged survival was dependant upon treatment--the length being directly associated with low initial ELISA values; and (c) treated animals were the only ones cured of disease.  Further investigations are envisaged to determine optimal, long-term dosages that may result in even better therapeutic outcomes as well as to evaluate potential application for therapy of the Johne's disease, human-counterpart, Crohn's disease."
3. Oral Administration
4. Lasers (Laser)
5. Therapeutics