Paraquat

A poisonous dipyridilium compound used as contact herbicide. Contact with concentrated solutions causes irritation of the skin, cracking and shedding of the nails, and delayed healing of cuts and wounds.

Also Known As:

Networked: 1588 relevant articles (76 outcomes, 197 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hong, Sae-Yong: 20 articles (01/2014 - 03/2002)
2.	Gil, Hyo-Wook: 17 articles (01/2014 - 09/2005)
3.	Lee, Eun-Young: 15 articles (06/2011 - 03/2002)
4.	Lin, Ja-Liang: 14 articles (01/2014 - 11/2002)
5.	Yang, Jong-Oh: 13 articles (06/2011 - 05/2002)
6.	Jian, Xiang-dong: 10 articles (11/2013 - 04/2007)
7.	Liu, Zhi: 9 articles (05/2015 - 05/2012)
8.	Cory-Slechta, Deborah A: 9 articles (03/2014 - 07/2002)
9.	Yen, Tzung-Hai: 9 articles (01/2014 - 07/2010)
10.	Singh, Mahendra Pratap: 9 articles (12/2013 - 04/2006)

Related Diseases

1.	Poisoning 10/01/1991 - "The most effective treatment of severe paraquat poisoning in man is uncertain. " 01/01/1987 - "There is a striking discrepancy between the efficacy of the kidneys, haemodialysis and haemoperfusion in removing paraquat from the body and the poor prognosis of paraquat poisoning even when the blood and urine concentrations (which are good indices of concentrations in lung and other tissues) are very low. " 01/01/1986 - "There is a striking discrepancy between: the efficacy of the kidneys, haemodialysis (HD) and Haemoperfusion (HP) in removing paraquat from the body and the poor prognosis of paraquat poisoning even when the blood and urine levels (which are good indices of concentrations in lung and other tissues) are very low. " 12/01/1997 - "It is also suggested that early haemoperfusion is effective in treating paraquat poisoning even in very severe cases due to its possible detoxicating effect in addition to toxin removal." 12/07/1974 - "Effective treatment for paraquat poisoning in rats and its relevance to treatment of paraquat poisoning in man."
2.	Lung Injury 01/01/2008 - "Anti-TGF-beta1 antibody: an effective treatment for lung injury caused by paraquat in the future." 06/01/2014 - "[The efficacy of traditional Chinese medicin in animal model of lung injury induced by paraquat: a meta-analysis]." 06/01/2009 - "The purpose of this study was to report the long-term evolution of lung lesions in eight survivors with significant paraquat-induced lung injuries who could be followed-up for longer than 6 months. " 10/12/2004 - "The aim of this study was to evaluate the time course of in vivo and in vitro respiratory mechanics and examine whether these parameters could reflect the temporal changes in lung parenchyma remodelling in paraquat (PQ)-induced lung injury. " 09/01/1992 - "The purpose of this study was to establish a chronic model of paraquat-induced lung injury. "
3.	Acute Lung Injury 01/01/2015 - "We hypothesized that SF and OMT combination treatment might have protective effects on paraquat-induced acute lung injury. " 06/01/2012 - "This study investigated the effect of the bark extract of Bathysa cuspidata on paraquat (PQ)-induced extra-pulmonary acute lung injury (ALI) and mortality in rats. " 02/01/2015 - "In conclusion, paraquat can induce IL-1β/IL-18 secretion via NLRP3-ASC-caspase-1 pathway, and the NLRP3 inflammasome is essential for paraquat-induced acute lung injury. " 02/01/2015 - "Acute lung injury was induced by administering paraquat (PQ) intraperitoneally. " 02/01/2015 - "The innate immune response is important in paraquat-induced acute lung injury, but the exact pathways involved are not elucidated. "
4.	Fibrosis (Cirrhosis) 04/01/1987 - "[An ultrastructural study of paraquat-induced intra-alveolar fibrosis of the lung]." 01/01/1987 - "Studies in experimental animals have demonstrated that paraquat produces an acute damaging phase in the lung, followed by a reparative phase dominated by an extensive fibrosis. " 01/01/2014 - " immune system plays an important role in exacerbating paraquat-induced lung fibrosis. " 06/01/2013 - "[The relationship of endoplasmic reticulum stress with paraquat induced lung fibrosis in rats]." 07/01/2012 - "Paraquat (PQ) is the second most widely used herbicide worldwide, but it selectively accumulates in human lungs to cause oxidative injury and fibrosis with high mortality. "
5.	Pulmonary Fibrosis (Hamman Rich Syndrome) 10/01/2008 - "TET has antagonistic effect against acute toxicity of paraquat through significant reduction of pulmonary fibrosis." 07/01/2013 - "Docosahexaenoic acid (DHA) ameliorates paraquat-induced pulmonary fibrosis in rats possibly through up-regulation of Smad 7 and SnoN." 11/15/2013 - "This study was carried out to highlight the role of PPARγ in the paraquat (PQ)-induced pulmonary fibrosis. " 07/01/2002 - "The next target of study will be to verify the mechanism of pulmonary fibrosis by paraquat on the basis of the outcome of studies such as this review." 06/01/1999 - "Paraquat is a commonly used herbicide world wide and is a well documented cause of pulmonary fibrosis in studies of laboratory animals and in humans after exposure to a high dose (usually accidental or as parasuicide). "

Related Drugs and Biologics

1.	Cyclophosphamide (Cytoxan)
2.	Methylprednisolone
3.	Ascorbic Acid (Vitamin C)
4.	Xuebijing
5.	Antioxidants
6.	Charcoal (Charbon)
7.	Dexamethasone (Maxidex)
8.	Sodium
9.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
10.	Vitamin E

Related Therapies and Procedures

1.	Hemoperfusion
2.	Renal Dialysis (Hemodialysis)
3.	Transplantation (Transplant Recipients)
4.	Continuous Positive Airway Pressure
5.	Emergency Treatment