Paraproteins

Abnormal immunoglobulins synthesized by atypical cells of the MONONUCLEAR PHAGOCYTE SYSTEM. Paraproteins containing only light chains lead to Bence Jones paraproteinemia, while the presence of only atypical heavy chains leads to heavy chain disease. Most of the paraproteins show themselves as an M-component (monoclonal gammopathy) in electrophoresis. Diclonal and polyclonal paraproteins are much less frequently encountered.

Networked: 242 relevant articles (5 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Pfreundschuh, Michael: 8 articles (09/2015 - 07/2007)
2.	Preuss, Klaus-Dieter: 7 articles (01/2015 - 07/2007)
3.	Regitz, Evi: 5 articles (01/2015 - 08/2009)
4.	Fadle, Natalie: 5 articles (01/2015 - 08/2009)
5.	Grass, Sandra: 5 articles (07/2011 - 08/2009)
6.	Kubuschok, Boris: 3 articles (09/2015 - 07/2007)
7.	Murawski, Niels: 3 articles (09/2015 - 08/2009)
8.	Chari, Ajai: 2 articles (10/2013 - 12/2009)
9.	Treon, Steven P: 2 articles (04/2013 - 03/2011)
10.	Ziepert, Marita: 2 articles (03/2011 - 03/2011)

Related Diseases

1.	Plasmacytoma 12/01/1963 - "[IMMUNO-ELECTROPHORETIC STUDIES OF THE PARAPROTEINS IN PLASMOCYTOMA]." 09/01/2008 - "This case report describes a patient with a solitary extramedullary plasmacytoma involving the pleura, and no evidence of serum, urine or pleural fluid paraproteins. " 01/01/1992 - "Previous work on human paraproteins of plasmocytoma and immunocytoma has shown that a high proportion of paraproteins bind to self determinants. " 05/31/1985 - "[Plasmacytomas without paraproteins]." 05/01/1982 - "The most important implication of our case is the fact that a follow-up of serum or urine concentrations of paraproteins may not reflect the course of a given plasmacytoma."
2.	Multiple Myeloma 10/01/2009 - "The aim of this study was to search for factors underlying the autoimmunogenicity of paratarg-7, a frequent antigenic target of paraproteins in MGUS and multiple myeloma. " 10/01/2014 - "Specifically, phosphate analysis may be disturbed by the paraproteins in patients with multiple myeloma, resulting in pseudohyperphosphatemia. " 01/01/2013 - "The diagnosis was non-secretory multiple myeloma without apparent secretion of paraproteins into the blood. " 08/01/2009 - "A frequent target of paraproteins in the sera of patients with multiple myeloma and MGUS." 07/15/2007 - "Identification of antigenic targets of paraproteins by expression cloning does not support a causal role of chronic antigenic stimulation in the pathogenesis of multiple myeloma and MGUS."
3.	Hemorrhage 01/01/1986 - "These studies indicate that bleeding occurring in dysproteinemia may be the result of a specific interaction of monoclonal paraproteins with platelets. " 06/01/2007 - "Finally, plasmapheresis and immunoadsorption to remove paraproteins may be helpful when other measures fail to curb bleeding." 01/01/1979 - "SDS-PAe additionally allows the differentiation of extrarenal proteinurias, as caused by overflow, paraproteins, postrenal Ig-secretion or bleeding etc. In comparing clinical and in part histological data of about 2,000 patients suffering from kidney diseases the analysis of urinary proteins by this method has been proved as valuable non-invasive tool for diagnosis and follow-up."
4.	Paraproteinemias (Monoclonal Gammopathy) 02/01/2011 - "We instead explored patient or disease-related factors that could be responsible, and present a case of plasma cell dyscrasia in which paraproteins caused hollow fiber failure. " 02/01/2009 - "These may occur as a result of the underlying disease process that causes paraproteinemia, or may result from the paraproteins affecting a physiologic function in vivo. " 09/01/2007 - "Understanding the pathogenetic role of paraproteins in peripheral nervous system damage is a necessary step to establish a link between the monoclonal gammopathy and neuropathy. " 01/01/2005 - "Strategy for characterization of paraproteins in the diagnosis of malignant monoclonal gammapathies." 01/01/1999 - "In last two years we have found 202 paraproteins by means of immunofixation electrophoresis and within this group multiple paraproteinemias was found 21 times, i.e. "
5.	Leukemia 01/01/1975 - "We wish to underline the existence of a Monoclonal Disglobulinemia (Paraproteins in the zone of Inmunoglobulin M); this observation was made in some cases of leukemia. " 09/01/1981 - "The coexistence of the two disorders was characterized by an initial reduction of paraproteinemia at the time that leukemia occurred, a long-lasting remission of the two disorders, and a final parallel increase of paraproteins and WBCs. " 06/15/1987 - "When the reactivity of this panel of anti-Id antibodies with nonhomologous B cell neoplasms was examined, seven of 30 myelomas or leukemia-derived products and one of nine B cell leukemias or lymphomas without paraproteins were found to be cross-reactive with one or two of the anti-Id antibodies. " 10/01/2003 - "One of the main indications for the use of apheresis is in the treatment of the hyperviscosity syndromes that can result from either the presence of abnormal plasma components, such as antibodies, immune complexes, paraproteins, and cryoglobulins, or the excessive increase in blood cells as seen in polycythemia, leukemias, and myeloproliferative diseases. "

Related Drugs and Biologics

1.	Proteasome Endopeptidase Complex (Proteasome)
2.	Peroxidase (Myeloperoxidase)
3.	Hemoglobins (Hemoglobin)
4.	bortezomib (Velcade)
5.	Immunoglobulin G (IgG)
6.	Immunoglobulin A (IgA)
7.	Immunoglobulin M (IgM)
8.	Silicones
9.	Melphalan (Alkeran)
10.	Blood Proteins (Serum Proteins)

Related Therapies and Procedures

1.	Plasmapheresis
2.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
3.	Renal Dialysis (Hemodialysis)
4.	Drug Therapy (Chemotherapy)
5.	Transplantation (Transplant Recipients)