A motor neuron disease marked by progressive weakness of the muscles innervated by cranial nerves of the lower brain stem. Clinical manifestations include dysarthria, dysphagia, facial weakness, tongue weakness, and fasciculations of the tongue and facial muscles. The adult form of the disease is marked initially by bulbar weakness which progresses to involve motor neurons throughout the neuroaxis. Eventually this condition may become indistinguishable from AMYOTROPHIC LATERAL SCLEROSIS. Fazio-Londe syndrome is an inherited form of this illness which occurs in children and young adults. (Adams et al., Principles of Neurology, 6th ed, p1091; Brain 1992 Dec;115(Pt 6):1889-1900)
Also Known As:
Fazio Londe Syndrome; Bulbar Palsy; Progressive Bulbar Palsy of Childhood; Syndrome, Fazio-Londe; Bulbar Palsy, Progressive; Bulbar Palsy, Progressive, Of Childhood; Childhood Progressive Bulbar Palsy; Bulbar Palsies; Bulbar Palsies, Progressive; Bulbar Paralyses; Bulbar Paralysis; Disease, Fazio-Londe; Disease, Fazio-Londe's; Fazio Londe Disease; Fazio Londe's Disease; Fazio Londe's Syndrome; Palsies, Bulbar; Palsies, Progressive Bulbar; Palsy, Bulbar; Palsy, Progressive Bulbar; Progressive Bulbar Palsies; Syndrome, Fazio-Londe's; Fazio-Londe Disease; Fazio-Londe Syndrome; Fazio-Londe's Disease; Fazio-Londe's Syndrome; Paralysis, Bulbar