Papain

A proteolytic enzyme obtained from Carica papaya. It is also the name used for a purified mixture of papain and CHYMOPAPAIN that is used as a topical enzymatic debriding agent. EC 3.4.22.2.

Also Known As:

Networked: 920 relevant articles (36 outcomes, 89 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Nakae, Susumu: 12 articles (01/2021 - 05/2013)
2.	Rosenthal, Philip J: 8 articles (01/2020 - 01/2002)
3.	Baker, Susan C: 8 articles (12/2017 - 12/2004)
4.	Matsuda, Akira: 7 articles (01/2021 - 05/2013)
5.	Okumura, Ko: 7 articles (01/2021 - 05/2013)
6.	Saito, Hirohisa: 7 articles (12/2018 - 05/2013)
7.	Takai, Toshiro: 6 articles (12/2021 - 05/2013)
8.	Bogyo, Matthew: 6 articles (11/2021 - 05/2007)
9.	Kamijo, Seiji: 5 articles (01/2021 - 05/2013)
10.	Ogawa, Hideoki: 5 articles (01/2021 - 05/2013)

Related Diseases

1.	Inflammation (Inflammations) 10/01/2023 - "Also, such ablation of the CB2 signal ameliorates papain-induced tissue inflammation. " 01/01/2018 - "The reduction in lung ILC2s caused a clear remission of airway inflammation in ICAM-1-/- mice after administration of papain or Alternaria alternata. " 10/30/2023 - "Rather, bone marrow chimera studies revealed thatDGKζ deficiency in the non-hematopoietic compartment was responsible for the reduction in papain-induced airway inflammation. " 11/07/2023 - "Finally, administration of anti-IL-7 antibody attenuated papain-induced inflammation by suppressing the activation of ILC2s. " 10/30/2023 - "Unexpectedly, however, mice with hematopoietic cell-specific deletion ofDGKζ displayed intact airway inflammation upon papain challenge. "
2.	Wounds and Injuries (Trauma) 06/15/2010 - "Efficacy of papain-based wound cleanser in promoting wound regeneration." 04/01/2017 - "The aim of this study was to evaluate the effect of 3% papain gel on wounds in mice. " 06/15/2010 - "This study describes the preparation and preclinical study of papain-based wound cleanser in accelerating wound healing. " 01/01/2022 - "Our results showed that papain-induced asthmatic mice exhibited apparent colonic injuries compared with controls, including increased intestinal permeability, neutrophil and Th17 infiltration in the colonic lamina propria. " 04/01/2017 - "On gross examination, the 3% papain-treated group took less time to heal the wounds compared with the control. "
3.	Osteoarthritis 08/01/2016 - "The aim of this experimental study is to evaluate the efficacy of a novel intraarticular drug in a papain induced osteoarthritis (OA) rat model and compare with the traditional hyaluronat (HA) visco supplementation. " 01/01/2022 - "Our study aimed to investigate the role of Dlx5 in papain-induced osteoarthritis. " 01/01/2015 - "This study was carried out to evaluate the effect of Vigna mungo hydroalcoholic extract (VMHA) by papain induced osteoarthritis (OA) in the rat model. " 01/01/2007 - "The aim of this study was to evaluate structural changes in relation to time with the use of the Mankin scoring system in papain-induced rat osteoarthritis. " 10/01/2002 - "[A study on papain-induced osteoarthritis in rabbit temporomandibular joint]."
4.	Pulmonary Emphysema 07/01/1989 - "The efficacy of constant-flow ventilation (CFV) was investigated in eight mongrel dogs before (control-phase) and after development of papain-induced panlobular emphysema (PLE-phase). " 01/01/1992 - "The study was carried out on an experimental papain induced model of pulmonary emphysema. " 12/01/1977 - "[Morphometric study of papain-induced pulmonary emphysema (author's transl)]." 08/15/2014 - "Papain-induced experimental pulmonary emphysema in male and female mice." 12/01/2006 - "Morphogenesis of rat experimental pulmonary emphysema induced by intratracheally administered papain: changes in elastic fibres."
5.	Neoplasms (Cancer) 10/01/1981 - "Spleen cells from the pretreated mice which subsequently received the immunization procedure could not regain the tumor-neutralizing activity after enzymatic treatment with papain. " 02/14/1976 - "Low T-cell levels return to normal after incubation with papain in virto but fall again after resuspending the treated lymphocytes in autologous (cancer) serum. " 09/15/1975 - "A microculture (200 mul) lymphocyte stimulation (LS) assay utilizing immune spleen cells was employed with mixed lymphocyte/tumor-cell cultures (MLTC) and the papain crude soluble (CS) extracts from mKSA-TU5 cells. " 01/01/1990 - "Inhibition of tumor growth, invasion and metastasis in papain-immunized mice." 05/01/1973 - "Thymus leukemia (TL) alloantigenic activity was solubilized by papain proteolytic digestion from intact RADA1 tumor cells. "

Related Drugs and Biologics

1.	Bromelains (Bromelain)
2.	Peptide Hydrolases (Proteases)
3.	Liposomes (Liposome)
4.	Proteins (Proteins, Gene)
5.	Enzymes
6.	Trypsin
7.	Solutions
8.	RNA-Dependent RNA Polymerase (RNA Dependent RNA Polymerase)
9.	Urea (Carbamide)
10.	Antigens

Related Therapies and Procedures

1.	Intra-Articular Injections
2.	Therapeutics
3.	Transplantation
4.	Solid-State Lasers
5.	Radiotherapy