Papain

A proteolytic enzyme obtained from Carica papaya. It is also the name used for a purified mixture of papain and CHYMOPAPAIN that is used as a topical enzymatic debriding agent. EC 3.4.22.2.

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Networked: 644 relevant articles (19 outcomes, 48 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Baker, Susan C: 14 articles (05/2015 - 12/2004)
2.	Mesecar, Andrew D: 10 articles (05/2015 - 12/2005)
3.	Ratia, Kiira: 7 articles (05/2014 - 12/2005)
4.	Rosenthal, Philip J: 7 articles (08/2010 - 01/2002)
5.	Chen, Zhongbin: 5 articles (07/2013 - 12/2005)
6.	Hoffman, Andrew: 5 articles (07/2005 - 03/2003)
7.	Mielech, Anna M: 4 articles (05/2015 - 02/2014)
8.	Nuss, Donald L: 4 articles (10/2014 - 08/2002)
9.	Nichols, Daniel B: 4 articles (10/2014 - 08/2009)
10.	Chou, Chi-Yuan: 4 articles (02/2014 - 04/2008)

Related Diseases

1.	Wounds and Injuries (Trauma) 06/15/2010 - "Efficacy of papain-based wound cleanser in promoting wound regeneration." 06/15/2010 - "This study describes the preparation and preclinical study of papain-based wound cleanser in accelerating wound healing. " 06/15/2010 - "In addition to its wound healing effect, papain-based wound cleanser is also integrated with antibacterial properties which make it a complete package for wound management. " 06/15/2010 - "A new invention, papain-based wound cleanser is formulated by incorporating papain, a proteolytic enzyme extracted from Carica papaya into the formulation. " 10/01/1987 - "[Healing of suppurative wounds after papain diadinamophoresis]."
2.	Pulmonary Emphysema 07/01/1989 - "The efficacy of constant-flow ventilation (CFV) was investigated in eight mongrel dogs before (control-phase) and after development of papain-induced panlobular emphysema (PLE-phase). " 01/01/1992 - "The study was carried out on an experimental papain induced model of pulmonary emphysema. " 08/15/2014 - "Papain-induced experimental pulmonary emphysema in male and female mice." 12/01/2006 - "Morphogenesis of rat experimental pulmonary emphysema induced by intratracheally administered papain: changes in elastic fibres." 01/01/2006 - "Effects of exercise training on papain-induced pulmonary emphysema in Wistar rats."
3.	Neoplasms (Cancer) 02/26/2013 - "Arteriviruses are economically important positive-stranded RNA viruses that encode an ovarian tumor (OTU) domain DUB known as papain-like protease 2 (PLP2). " 10/01/1981 - "Spleen cells from the pretreated mice which subsequently received the immunization procedure could not regain the tumor-neutralizing activity after enzymatic treatment with papain. " 01/15/1998 - "It is the only known mono-aminopeptidase in the papain-like family and is reported to be involved in tumor metastasis. " 01/01/1990 - "Inhibition of tumor growth, invasion and metastasis in papain-immunized mice." 07/01/1979 - "This paper describes results of glycosaminoglycan electrophoresis of papain digests of 7 mesotheliomas and 27 other tumors. "
4.	Severe Acute Respiratory Syndrome 10/01/2014 - "We used this system to demonstrate the in vivo efficacy of an inhibitor of the papain-like protease of severe acute respiratory syndrome coronavirus. " 10/01/2014 - "Here, we exploit a biosafety level 2 (BSL-2) chimeric Sindbis virus system to evaluate protease activities and the efficacy of inhibitors directed against the papain-like protease (PLpro) of severe acute respiratory syndrome coronavirus (SARS-CoV), a biosafety level 3 (BSL-3) pathogen. " 05/01/2015 - "Structural studies of the papain-like protease (PLP) domains of coronaviruses (CoVs) revealed an adjacent Ubl domain in severe acute respiratory syndrome CoV, Middle East respiratory syndrome CoV, and the murine CoV, mouse hepatitis virus (MHV). " 05/01/2014 - "Severe acute respiratory syndrome coronavirus (SARS-CoV) encodes a papain-like protease (PLpro) with both deubiquitinating (DUB) and deISGylating activities that are proposed to counteract the post-translational modification of signaling molecules that activate the innate immune response. " 02/01/2014 - "Severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) is a key enzyme that plays an important role in SARS virus replication. "
5.	Infection 01/01/1984 - "The high chemotherapeutic efficacy of the antibiotic combinations with papain allowed recommending it for use in clinical practice for the treatment of infections caused by antibiotic-resistant staphylococci." 07/09/2015 - "We have recently shown that the deubiquitinase (DUB) activity of EAV papain-like protease 2 (PLP2) is important for the inhibition of innate immune activation during infection. " 06/01/2015 - "Inactivation of Bcl11b causes a complete loss of ILC2 development from hematopoietic progenitors, which is confirmed upon immune challenge with either papain administration or influenza virus infection." 05/01/2014 - "Dr3(-/-) mice failed to control gut helminthic infections, and failed to mount ILC2 responses in the lung after nasal challenge with papain. " 01/01/2014 - "Recently, we showed that the administration of active papain to mice induced significant protection (P<0.02, 50%) against an experimental challenge infection with Schistosoma mansoni. "

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6.	Pancreatic Elastase (Elastase)
7.	Liposomes (Liposome)
8.	Antigens
9.	Collagenases (Collagenase)
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