Pantetheine

An intermediate in the pathway of coenzyme A formation in mammalian liver and some microorganisms.

Also Known As:

Butanamide, 2,4-dihydroxy-N-(3-((2-mercaptoethyl)amino)-3-oxopropyl)-3,3-dimethyl-, (R)-

Networked: 23 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cui, Jingnan: 1 article (01/2022)
2.	Deng, Sa: 1 article (01/2022)
3.	Feng, Lei: 1 article (01/2022)
4.	Huang, Shanshan: 1 article (01/2022)
5.	Ma, Xiaochi: 1 article (01/2022)
6.	Tian, Xiangge: 1 article (01/2022)
7.	Tian, Zhenhao: 1 article (01/2022)
8.	Xie, Tian: 1 article (01/2022)
9.	Yan, Fei: 1 article (01/2022)
10.	Zhang, Baojing: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 02/18/2016 - "In addition, the concentration of homocysteine, γ-glutamylcysteine and pantetheine enhanced more than two folds in cancer patients compared to healthy controls. " 08/01/2018 - "Given the importance of the cofactor coenzyme A (CoA) in energy metabolism, we investigated the impact of Vnn1 pantetheinase-an enzyme that degrades pantetheine into pantothenate (vitamin B5, the CoA biosynthetic precursor) and cysyteamine-on tumor growth. "
2.	Infections 12/09/2016 - "Silencing of coaBC was likewise bactericidal in vivo, whether initiated at infection or during either the acute or chronic stages of infection, confirming that CoaBC is required for M. tuberculosis to grow and persist in mice and arguing against significant CoaBC bypass via transport and assimilation of host-derived pantetheine in this animal model. " 01/01/2017 - "Pantetheine significantly reduced the IAV replication and IAV Matrix 1 (M1) mRNA levels when it was administered prior to and during infection. " 01/01/2017 - "The messenger RNA expression of VNN1 in A549 cells was significantly increased (by 4.9-fold) after IAV infection under an elevated concentration of pantetheine. " 01/01/2017 - "Here, to elucidate the role of VNN1 in influenza A virus (IAV) H1N1 infection, we investigated the change of VNN1 expression in the context of IAV infection and the effects of its related substances, i.e., its direct substrate pantetheine and its two metabolites pantothenic acid and cysteamine on the replication of IAV in the human alveolar epithelial carcinoma cell line A549. "
3.	Hyperlipidemias (Hyperlipidemia) 09/30/1986 - "[Clinical study on the anti-lipidemia and anti-steatosis effectiveness of the pantetheine-phosphorylcholine pharmacologic combination]." 01/01/1987 - "Recent investigations have confirmed the effectiveness and the excellent tolerability of pantethine, a derivative of pantetheine, an essential part of the acetylation coenzyme CoA, administered P.O., in normalizing the blood lipid concentrations of patients with hyperlipidemias. "
4.	Fatty Liver 09/14/1982 - "Controlled proteolytic cleavage of 4'-phospho[14C]pantetheine-labeled pigeon liver fatty acid synthetase generates two 4'-phospho[14C]pantetheine-labeled peptides, Ec1 and Ec2. " 06/25/1975 - "The separation of the half-molecular weight, nonidentical subunits (I and II) of the pigeon liver fatty acid synthetase complex has been achieved on a large (20 mg) scale by affinity chromatography on Sepharose epsilon-aminocaproyl pantetheine. "
5.	Dehydration (Water Stress) 07/10/1975 - "Acetyl- and malonyl-CoA-pantetheine transacylase activities as well as the kinetics of the reduction and dehydration steps are nearly identical for the native and the modified enzymes. " 05/16/1989 - "The primary, alpha-secondary, beta-secondary, and beta'-secondary deuterium and primary 18O kinetic isotope effects on V/K for the dehydration of [(3S)-3-hydroxybutyryl]pantetheine by bovine liver crotonase (enoyl-CoA hydratase, EC 4.2.1.17) have been determined by the equilibrium perturbation method. "

Related Drugs and Biologics

1.	Coenzyme A (CoA)
2.	pantethine
3.	Pantothenic Acid (Calcium Pantothenate)
4.	Cysteamine (Mercaptamine)
5.	Lipids
6.	Ligases (Synthetase)
7.	Enzymes
8.	Disulfides
9.	Calcium
10.	Acids

Related Therapies and Procedures

1.	Therapeutics